International Academic Journals

Plant species genetics, cell culture, Elisa kits, antibodies

Design, synthesis, and evaluation of HIV-1 entry inhibitors based on broadly neutralizing antibody 447-52D and gp120 V3loop interactions

The third variable loop area (V3 loop) on gp120 performs an necessary position in mobile entry of HIV-1. Its interplay with the mobile CD4 and coreceptors is a crucial hallmark in facilitating the bridging by gp41 and subsequent fusion of membranes for switch of viral genetic materials. Additional, the virus phenotype determines the cell tropism by way of respective co- receptor binding. Thus, coreceptor binding motif of envelope is taken into...