International Academic Journals

Plant species genetics, cell culture, Elisa kits, antibodies

A Curious Novel Combination of Nucleophosmin ( NPM1) Gene Mutations Leading to Aberrant Cytoplasmic Dislocation of NPM1 in Acute Myeloid Leukemia (AML)

Nucleophosmin (NPM1) mutations occurring in acute myeloid leukemia (AML) (about 50 up to now recognized) cluster nearly completely in exon 12 and result in frequent modifications on the NPM1 mutants C-terminus, i.e., lack of tryptophans 288 and 290 (or 290 alone) and creation of a brand new nuclear export sign (NES), on the bases of exportin-1(XPO1)-mediated aberrant cytoplasmic NPM1. Immunohistochemistry (IHC) detects cytoplasmic NPM1 and...