Neutralizing Monoclonal Antibodies That Target the Spike Receptor Binding Domain Confer Fc Receptor-Independent Protection against SARS-CoV-2 Infection in Syrian Hamsters

Neutralizing Monoclonal Antibodies That Target the Spike Receptor Binding Domain Confer Fc Receptor-Independent Protection against SARS-CoV-2 Infection in Syrian Hamsters
The extreme acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein is the principle goal for neutralizing antibodies. These antibodies might be elicited by means of immunization or passively transferred as therapeutics within the type of convalescent-phase sera or monoclonal antibodies (MAbs). Potently neutralizing antibodies are anticipated to confer safety; nevertheless, it’s unclear whether or not weakly neutralizing antibodies contribute to safety.
Additionally, their mechanism of motion in vivo is incompletely understood. Right here, we show that 2B04, an antibody with an ultrapotent neutralizing exercise (50% inhibitory focus [IC50] of 0.04 μg/ml), protects hamsters towards SARS-CoV-2 in a prophylactic and therapeutic an infection mannequin. Safety is related to diminished weight reduction and viral hundreds in nasal turbinates and lungs after problem.
MAb 2B04 additionally blocked aerosol transmission of the virus to naive contacts. We subsequent examined three extra MAbs (2C02, 2C03, and 2E06), recognizing distinct epitopes inside the receptor binding area of spike protein that possess both minimal (2C02 and 2E06, IC50 > 20 μg/ml) or weak (2C03, IC50 of 5 μg/ml) virus neutralization capability in vitro. Solely 2C03 protected Syrian hamsters from weight reduction and diminished lung viral load after SARS-CoV-2 an infection.
Lastly, we demonstrated that Fc-Fc receptor interactions weren’t required for cover when 2B04 and 2C03 have been administered prophylactically. These findings inform the mechanism of safety and help the rational improvement of antibody-mediated safety towards SARS-CoV-2 infections. IMPORTANCE The continued coronavirus illness 2019 (COVID-19) pandemic, brought on by SARS-CoV-2, has resulted within the lack of thousands and thousands of lives. Protected and efficient vaccines are thought of the last word treatment for the worldwide social and financial disruption brought on by the pandemic.
Nevertheless, an intensive understanding of the immune correlates of safety towards this virus is missing. Right here, we characterised 4 completely different monoclonal antibodies and evaluated their capability to forestall or deal with SARS-CoV-2 an infection in Syrian hamsters. These antibodies various of their capability to neutralize the virus in vitro. Prophylactic administration of potent and weakly neutralizing antibodies protected towards SARS-CoV-2 an infection, and this impact was Fc receptor unbiased.
The potent neutralizing antibody additionally had therapeutic efficacy and eradicated onward aerosol transmission. In distinction, minimally neutralizing antibodies offered no safety towards an infection with SARS-CoV-2 in Syrian hamsters. Mixed, these research spotlight the importance of weakly neutralizing antibodies within the safety towards SARS-CoV-2 an infection and related illness.

Fast and quantitative detection of SARS-CoV-2 IgG antibody in serum utilizing optofluidic point-of-care testing fluorescence biosensor

The COVID-19 pandemic brings unprecedented disaster for public well being and economics on the earth. Detecting particular antibodies to SARS-CoV-2 is a strong complement for the analysis of COVID-19 and is essential for epidemiological research and vaccine validations. Herein, a speedy and quantitative detection methodology of anti-SARS-CoV-2 IgG antibody was constructed based mostly on the optofluidic point-of-care testing fluorescence biosensor.
With out difficult steps wanted, the moveable system is appropriate for on-site delicate dedication of anti-SARS-CoV-2 IgG antibody in serum. Beneath the optimum situations, the entire detection process is about 25 min with a detection restrict of 12.5 ng/mL that may nicely meet the diagnostic necessities. The tactic was not clearly affected by IgM and serum matrix and demonstrated to have good stability and reliability in actual pattern evaluation.
In comparison with ELISA take a look at outcomes, the proposed methodology reveals a number of benefits together with wider measurement vary and simpler operation. The tactic supplies a common platform for speedy and quantitative evaluation of different associated biomarkers, which is of significance for the prevention and management of COVID-19 pandemic.

Non-Genetic Technology of Antibody Conjugates Based mostly on Chemoenzymatic Tyrosine Click on Chemistry

The provision of instruments to generate homogeneous and secure antibody conjugates with out recombinant DNA know-how is a precious asset in fields spanning from in vitro diagnostics to in vivo imaging and therapeutics. We current right here a common method for the conjugation to human IgG1 antibodies, by using an easy two-stage protocol based mostly on antibody deglycosylation adopted by tyrosinase-mediated ortho-quinone strain-promoted click on chemistry. The know-how is validated by the environment friendly and clear era of extremely potent DAR2 and DAR4 antibody-drug conjugates (ADCs) with cytotoxic payloads MMAE or PBD dimer, and their in vitro analysis.

Section 1a/b Examine of Monoclonal Antibody CAEL-101 (11-1F4) in Sufferers with AL Amyloidosis

Systemic immunoglobulin light-chain (AL) amyloidosis is characterised by pathologic deposition of immunoglobulin gentle chains as amyloid fibrils in very important organs, resulting in organ impairment and eventual dying. That the method is reversible was evidenced in an in vivo experimental mannequin through which fibril-reactive chimeric monoclonal antibody (mAb) 11-1F4 straight focused human light-chain amyloid deposits and effected their elimination through a phagocyte-mediated response.
To find out tolerability and potential amyloidolytic impact of this agent (now designated mAb CAEL-101), we carried out a part 1a/b research involving 27 sufferers, most of whom had manifestations of organ involvement. This was an open label research through which part 1a sufferers acquired mAb CAEL-101 as a single intravenous infusion, with escalating dose ranges from 0.5 mg/m2 to 500 mg/m2 to determine the most tolerated dose (MTD). In part 1b, the antibody was administered as a graded sequence of 4 weekly infusions.
For each phases, there have been no drug-related critical antagonistic occasions or dose-limiting toxicities amongst recipients and the MTD was not reached. Majority of sufferers had deep hematologic responses however persistent organ illness previous to remedy. Fifteen of 24 sufferers (63%) who manifested cardiac, renal, hepatic, gastrointestinal, or smooth tissue involvement had a therapeutic response to mAb CAEL-101 as evidenced by serum biomarkers or goal imaging modalities with median time to response of three weeks. Infusions of mAb CAEL-101 have been well-tolerated and, for almost all, resulted in improved organ perform, notably for these with cardiac impairment.

A Comparability of the Efficiency of SARS-CoV-2 Antibody Assays in Healthcare Staff with COVID-19

Goals Since its emergence, vital curiosity surrounds the usage of SARS-CoV-2 serological exams as a substitute or as an adjunct to molecular testing. Nevertheless, given the velocity of this pandemic, paralleled with the stress to develop and supply serological exams in an expediated method, not each assay has undergone the rigorous analysis that’s normally related to medical diagnostic assays.
We aimed to look at the efficiency of a number of commercially out there SARS-CoV-2 IgG antibody assays amongst members with confirmed COVID-19 illness and detrimental controls. Strategies Serum taken between day 17 and day 40 publish onset of signs from 41 healthcare employees with RT-PCR confirmed COVID-19 illness, and pre-pandemic serum from 20 detrimental controls, have been examined for the presence of SARS-CoV-2 IgG utilizing 7 completely different assays together with point-of-care (POC) and laboratory-based assays. Outcomes Assay efficiency various.

VEGF Rabbit Polyclonal Antibody

ES8453-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against VEGF Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

VEGF Rabbit Polyclonal Antibody

ES8453-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against VEGF Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

CD10 Rabbit Polyclonal Antibody

ES8454-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against CD10 Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

CD10 Rabbit Polyclonal Antibody

ES8454-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against CD10 Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

NM23A Rabbit Polyclonal Antibody

ES8455-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against NM23A Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

NM23A Rabbit Polyclonal Antibody

ES8455-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against NM23A Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

ATM Rabbit Polyclonal Antibody

ES8456-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against ATM Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

ATM Rabbit Polyclonal Antibody

ES8456-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against ATM Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

ATM Rabbit Polyclonal Antibody

ES8457-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against ATM Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

ATM Rabbit Polyclonal Antibody

ES8457-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against ATM Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

HSC70 Rabbit Polyclonal Antibody

ES8558-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against HSC70 Rabbit from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC

HSC70 Rabbit Polyclonal Antibody

ES8558-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against HSC70 Rabbit from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC

HSP40 Rabbit Polyclonal Antibody

ES8559-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against HSP40 Rabbit from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC

HSP40 Rabbit Polyclonal Antibody

ES8559-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against HSP40 Rabbit from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC

HSP90? Rabbit Polyclonal Antibody

ES8560-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against HSP90? Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

HSP90? Rabbit Polyclonal Antibody

ES8560-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against HSP90? Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

IkB ? Rabbit Polyclonal Antibody

ES8561-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against IkB ? Rabbit from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC

IkB ? Rabbit Polyclonal Antibody

ES8561-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against IkB ? Rabbit from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC

JAK1 Rabbit Polyclonal Antibody

ES8562-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against JAK1 Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

JAK1 Rabbit Polyclonal Antibody

ES8562-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against JAK1 Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

JAK2 Rabbit Polyclonal Antibody

ES8563-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against JAK2 Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

JAK2 Rabbit Polyclonal Antibody

ES8563-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against JAK2 Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

JNK2 Rabbit Polyclonal Antibody

ES8564-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against JNK2 Rabbit from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC

JNK2 Rabbit Polyclonal Antibody

ES8564-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against JNK2 Rabbit from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC

JNK3 Rabbit Polyclonal Antibody

ES8565-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against JNK3 Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

JNK3 Rabbit Polyclonal Antibody

ES8565-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against JNK3 Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

MEK2 Rabbit Polyclonal Antibody

ES8566-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against MEK2 Rabbit from Human. This antibody is tested and validated for WB, ELISA, IHC

MEK2 Rabbit Polyclonal Antibody

ES8566-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against MEK2 Rabbit from Human. This antibody is tested and validated for WB, ELISA, IHC

MEK3 Rabbit Polyclonal Antibody

ES8567-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against MEK3 Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

MEK3 Rabbit Polyclonal Antibody

ES8567-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against MEK3 Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

Nrf2 Rabbit Polyclonal Antibody

ES8568-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against Nrf2 Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

Nrf2 Rabbit Polyclonal Antibody

ES8568-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against Nrf2 Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

ATG4a Rabbit Polyclonal Antibody

ES8569-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against ATG4a Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

ATG4a Rabbit Polyclonal Antibody

ES8569-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against ATG4a Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

ATG4b Rabbit Polyclonal Antibody

ES8570-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against ATG4b Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

ATG4b Rabbit Polyclonal Antibody

ES8570-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against ATG4b Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

ATG4c Rabbit Polyclonal Antibody

ES8571-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against ATG4c Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

ATG4c Rabbit Polyclonal Antibody

ES8571-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against ATG4c Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

ATG5 Rabbit Polyclonal Antibody

ES8572-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against ATG5 Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

ATG5 Rabbit Polyclonal Antibody

ES8572-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against ATG5 Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

ATG7 Rabbit Polyclonal Antibody

ES8573-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against ATG7 Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

ATG7 Rabbit Polyclonal Antibody

ES8573-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against ATG7 Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

ATG13 Rabbit Polyclonal Antibody

ES8574-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against ATG13 Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

ATG13 Rabbit Polyclonal Antibody

ES8574-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against ATG13 Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

ATG13 Rabbit Polyclonal Antibody

ES8575-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against ATG13 Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

ATG13 Rabbit Polyclonal Antibody

ES8575-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against ATG13 Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

ATG14L Rabbit Polyclonal Antibody

ES8576-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against ATG14L Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

ATG14L Rabbit Polyclonal Antibody

ES8576-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against ATG14L Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

NBR1 Rabbit Polyclonal Antibody

ES8578-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against NBR1 Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

NBR1 Rabbit Polyclonal Antibody

ES8578-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against NBR1 Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

NBR1 Rabbit Polyclonal Antibody

ES8579-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against NBR1 Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

NBR1 Rabbit Polyclonal Antibody

ES8579-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against NBR1 Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

WIPI2 Rabbit Polyclonal Antibody

ES8580-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against WIPI2 Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

WIPI2 Rabbit Polyclonal Antibody

ES8580-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against WIPI2 Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

Gab1 Rabbit Polyclonal Antibody

ES8582-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against Gab1 Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

Gab1 Rabbit Polyclonal Antibody

ES8582-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against Gab1 Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

ERK1 Rabbit Polyclonal Antibody

ES8583-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against ERK1 Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

ERK1 Rabbit Polyclonal Antibody

ES8583-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against ERK1 Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

Rabbit Anti FITC Antibody

E61I01402 100ug
EUR 343

GAPDH Rabbit Polyclonal Antibody

A01021-005ml 0.05ml
EUR 147
Description: A polyclonal antibody for detection of GAPDH from Human, Mouse, Rat, Rabbit, Chicken, Monkey, Sheep, Xneous. This GAPDH antibody is for WB, IHC-P. It is affinity-purified from rabbit antiserum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen recombinant protein

GAPDH Rabbit Polyclonal Antibody

A01021-02ml 0.2ml
EUR 332
Description: A polyclonal antibody for detection of GAPDH from Human, Mouse, Rat, Rabbit, Chicken, Monkey, Sheep, Xneous. This GAPDH antibody is for WB, IHC-P. It is affinity-purified from rabbit antiserum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen recombinant protein

GAPDH Rabbit Polyclonal Antibody

A01021-02ml5 0.2ml×5
EUR 920
Description: A polyclonal antibody for detection of GAPDH from Human, Mouse, Rat, Rabbit, Chicken, Monkey, Sheep, Xneous. This GAPDH antibody is for WB, IHC-P. It is affinity-purified from rabbit antiserum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen recombinant protein

Aldolase (Rabbit Muscle) Antibody

abx022821-50mg 50 mg
EUR 1052

Rabbit Hemoglobin Polyclonal Antibody

A53073 100 µg
EUR 570.55
Description: The best epigenetics products

p40(Rabbit PAb) Antibody

BNCA0375-250 250uL
EUR 383
Description: Primary antibody against p40(Rabbit PAb), APC conjugate, Concentration: 0.1mg/mL

CD3e(Rabbit PAb) Antibody

BNCA0385-250 250uL
EUR 383
Description: Primary antibody against CD3e(Rabbit PAb), APC conjugate, Concentration: 0.1mg/mL

CD8a(Rabbit PAb) Antibody

BNCA0386-250 250uL
EUR 383
Description: Primary antibody against CD8a(Rabbit PAb), APC conjugate, Concentration: 0.1mg/mL

TIMP3(Rabbit PAb) Antibody

BNCA0408-250 250uL
EUR 383
Description: Primary antibody against TIMP3(Rabbit PAb), APC conjugate, Concentration: 0.1mg/mL

p40(Rabbit PAb) Antibody

BNCAP0375-100 100uL
EUR 199
Description: Primary antibody against p40(Rabbit PAb), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

p40(Rabbit PAb) Antibody

BNCAP0375-500 500uL
EUR 544
Description: Primary antibody against p40(Rabbit PAb), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

CD3e(Rabbit PAb) Antibody

BNCAP0385-100 100uL
EUR 199
Description: Primary antibody against CD3e(Rabbit PAb), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

CD3e(Rabbit PAb) Antibody

BNCAP0385-500 500uL
EUR 544
Description: Primary antibody against CD3e(Rabbit PAb), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

CD8a(Rabbit PAb) Antibody

BNCAP0386-100 100uL
EUR 199
Description: Primary antibody against CD8a(Rabbit PAb), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

CD8a(Rabbit PAb) Antibody

BNCAP0386-500 500uL
EUR 544
Description: Primary antibody against CD8a(Rabbit PAb), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

TIMP3(Rabbit PAb) Antibody

BNCAP0408-100 100uL
EUR 199
Description: Primary antibody against TIMP3(Rabbit PAb), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

TIMP3(Rabbit PAb) Antibody

BNCAP0408-500 500uL
EUR 544
Description: Primary antibody against TIMP3(Rabbit PAb), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

p40(Rabbit PAb) Antibody

BNC810375-100 100uL
EUR 199
Description: Primary antibody against p40(Rabbit PAb), CF680R conjugate, Concentration: 0.1mg/mL

p40(Rabbit PAb) Antibody

BNC810375-500 500uL
EUR 544
Description: Primary antibody against p40(Rabbit PAb), CF680R conjugate, Concentration: 0.1mg/mL

CD3e(Rabbit PAb) Antibody

BNC810385-100 100uL
EUR 199
Description: Primary antibody against CD3e(Rabbit PAb), CF680R conjugate, Concentration: 0.1mg/mL

CD3e(Rabbit PAb) Antibody

BNC810385-500 500uL
EUR 544
Description: Primary antibody against CD3e(Rabbit PAb), CF680R conjugate, Concentration: 0.1mg/mL

CD8a(Rabbit PAb) Antibody

BNC810386-100 100uL
EUR 199
Description: Primary antibody against CD8a(Rabbit PAb), CF680R conjugate, Concentration: 0.1mg/mL

CD8a(Rabbit PAb) Antibody

BNC810386-500 500uL
EUR 544
Description: Primary antibody against CD8a(Rabbit PAb), CF680R conjugate, Concentration: 0.1mg/mL

TIMP3(Rabbit PAb) Antibody

BNC810408-100 100uL
EUR 199
Description: Primary antibody against TIMP3(Rabbit PAb), CF680R conjugate, Concentration: 0.1mg/mL

TIMP3(Rabbit PAb) Antibody

BNC810408-500 500uL
EUR 544
Description: Primary antibody against TIMP3(Rabbit PAb), CF680R conjugate, Concentration: 0.1mg/mL

p40(Rabbit PAb) Antibody

BNC880375-100 100uL
EUR 199
Description: Primary antibody against p40(Rabbit PAb), CF488A conjugate, Concentration: 0.1mg/mL

p40(Rabbit PAb) Antibody

BNC880375-500 500uL
EUR 544
Description: Primary antibody against p40(Rabbit PAb), CF488A conjugate, Concentration: 0.1mg/mL

CD3e(Rabbit PAb) Antibody

BNC880385-100 100uL
EUR 199
Description: Primary antibody against CD3e(Rabbit PAb), CF488A conjugate, Concentration: 0.1mg/mL

CD3e(Rabbit PAb) Antibody

BNC880385-500 500uL
EUR 544
Description: Primary antibody against CD3e(Rabbit PAb), CF488A conjugate, Concentration: 0.1mg/mL

CD8a(Rabbit PAb) Antibody

BNC880386-100 100uL
EUR 199
Description: Primary antibody against CD8a(Rabbit PAb), CF488A conjugate, Concentration: 0.1mg/mL

CD8a(Rabbit PAb) Antibody

BNC880386-500 500uL
EUR 544
Description: Primary antibody against CD8a(Rabbit PAb), CF488A conjugate, Concentration: 0.1mg/mL

TIMP3(Rabbit PAb) Antibody

BNC880408-100 100uL
EUR 199
Description: Primary antibody against TIMP3(Rabbit PAb), CF488A conjugate, Concentration: 0.1mg/mL

TIMP3(Rabbit PAb) Antibody

BNC880408-500 500uL
EUR 544
Description: Primary antibody against TIMP3(Rabbit PAb), CF488A conjugate, Concentration: 0.1mg/mL

p40(Rabbit PAb) Antibody

BNCB0375-100 100uL
EUR 199
Description: Primary antibody against p40(Rabbit PAb), Biotin conjugate, Concentration: 0.1mg/mL

p40(Rabbit PAb) Antibody

BNCB0375-500 500uL
EUR 544
Description: Primary antibody against p40(Rabbit PAb), Biotin conjugate, Concentration: 0.1mg/mL

CD3e(Rabbit PAb) Antibody

BNCB0385-100 100uL
EUR 199
Description: Primary antibody against CD3e(Rabbit PAb), Biotin conjugate, Concentration: 0.1mg/mL

CD3e(Rabbit PAb) Antibody

BNCB0385-500 500uL
EUR 544
Description: Primary antibody against CD3e(Rabbit PAb), Biotin conjugate, Concentration: 0.1mg/mL

CD8a(Rabbit PAb) Antibody

BNCB0386-100 100uL
EUR 199
Description: Primary antibody against CD8a(Rabbit PAb), Biotin conjugate, Concentration: 0.1mg/mL

CD8a(Rabbit PAb) Antibody

BNCB0386-500 500uL
EUR 544
Description: Primary antibody against CD8a(Rabbit PAb), Biotin conjugate, Concentration: 0.1mg/mL

TIMP3(Rabbit PAb) Antibody

BNCB0408-100 100uL
EUR 199
Description: Primary antibody against TIMP3(Rabbit PAb), Biotin conjugate, Concentration: 0.1mg/mL

TIMP3(Rabbit PAb) Antibody

BNCB0408-500 500uL
EUR 544
Description: Primary antibody against TIMP3(Rabbit PAb), Biotin conjugate, Concentration: 0.1mg/mL

p40(Rabbit PAb) Antibody

BNC550375-100 100uL
EUR 199
Description: Primary antibody against p40(Rabbit PAb), CF555 conjugate, Concentration: 0.1mg/mL

p40(Rabbit PAb) Antibody

BNC550375-500 500uL
EUR 544
Description: Primary antibody against p40(Rabbit PAb), CF555 conjugate, Concentration: 0.1mg/mL

CD3e(Rabbit PAb) Antibody

BNC550385-100 100uL
EUR 199
Description: Primary antibody against CD3e(Rabbit PAb), CF555 conjugate, Concentration: 0.1mg/mL

CD3e(Rabbit PAb) Antibody

BNC550385-500 500uL
EUR 544
Description: Primary antibody against CD3e(Rabbit PAb), CF555 conjugate, Concentration: 0.1mg/mL

CD8a(Rabbit PAb) Antibody

BNC550386-100 100uL
EUR 199
Description: Primary antibody against CD8a(Rabbit PAb), CF555 conjugate, Concentration: 0.1mg/mL

CD8a(Rabbit PAb) Antibody

BNC550386-500 500uL
EUR 544
Description: Primary antibody against CD8a(Rabbit PAb), CF555 conjugate, Concentration: 0.1mg/mL

TIMP3(Rabbit PAb) Antibody

BNC550408-100 100uL
EUR 199
Description: Primary antibody against TIMP3(Rabbit PAb), CF555 conjugate, Concentration: 0.1mg/mL

TIMP3(Rabbit PAb) Antibody

BNC550408-500 500uL
EUR 544
Description: Primary antibody against TIMP3(Rabbit PAb), CF555 conjugate, Concentration: 0.1mg/mL

p40(Rabbit PAb) Antibody

BNC430375-100 100uL
EUR 199
Description: Primary antibody against p40(Rabbit PAb), CF543 conjugate, Concentration: 0.1mg/mL

p40(Rabbit PAb) Antibody

BNC430375-500 500uL
EUR 544
Description: Primary antibody against p40(Rabbit PAb), CF543 conjugate, Concentration: 0.1mg/mL

CD3e(Rabbit PAb) Antibody

BNC430385-100 100uL
EUR 199
Description: Primary antibody against CD3e(Rabbit PAb), CF543 conjugate, Concentration: 0.1mg/mL

CD3e(Rabbit PAb) Antibody

BNC430385-500 500uL
EUR 544
Description: Primary antibody against CD3e(Rabbit PAb), CF543 conjugate, Concentration: 0.1mg/mL

CD8a(Rabbit PAb) Antibody

BNC430386-100 100uL
EUR 199
Description: Primary antibody against CD8a(Rabbit PAb), CF543 conjugate, Concentration: 0.1mg/mL

CD8a(Rabbit PAb) Antibody

BNC430386-500 500uL
EUR 544
Description: Primary antibody against CD8a(Rabbit PAb), CF543 conjugate, Concentration: 0.1mg/mL

TIMP3(Rabbit PAb) Antibody

BNC430408-100 100uL
EUR 199
Description: Primary antibody against TIMP3(Rabbit PAb), CF543 conjugate, Concentration: 0.1mg/mL

TIMP3(Rabbit PAb) Antibody

BNC430408-500 500uL
EUR 544
Description: Primary antibody against TIMP3(Rabbit PAb), CF543 conjugate, Concentration: 0.1mg/mL

p40(Rabbit PAb) Antibody

BNC470375-100 100uL
EUR 199
Description: Primary antibody against p40(Rabbit PAb), CF647 conjugate, Concentration: 0.1mg/mL

p40(Rabbit PAb) Antibody

BNC470375-500 500uL
EUR 544
Description: Primary antibody against p40(Rabbit PAb), CF647 conjugate, Concentration: 0.1mg/mL

CD3e(Rabbit PAb) Antibody

BNC470385-100 100uL
EUR 199
Description: Primary antibody against CD3e(Rabbit PAb), CF647 conjugate, Concentration: 0.1mg/mL

CD3e(Rabbit PAb) Antibody

BNC470385-500 500uL
EUR 544
Description: Primary antibody against CD3e(Rabbit PAb), CF647 conjugate, Concentration: 0.1mg/mL

CD8a(Rabbit PAb) Antibody

BNC470386-100 100uL
EUR 199
Description: Primary antibody against CD8a(Rabbit PAb), CF647 conjugate, Concentration: 0.1mg/mL

CD8a(Rabbit PAb) Antibody

BNC470386-500 500uL
EUR 544
Description: Primary antibody against CD8a(Rabbit PAb), CF647 conjugate, Concentration: 0.1mg/mL

TIMP3(Rabbit PAb) Antibody

BNC470408-100 100uL
EUR 199
Description: Primary antibody against TIMP3(Rabbit PAb), CF647 conjugate, Concentration: 0.1mg/mL

TIMP3(Rabbit PAb) Antibody

BNC470408-500 500uL
EUR 544
Description: Primary antibody against TIMP3(Rabbit PAb), CF647 conjugate, Concentration: 0.1mg/mL

p40(Rabbit PAb) Antibody

BNC940375-100 100uL
EUR 199
Description: Primary antibody against p40(Rabbit PAb), CF594 conjugate, Concentration: 0.1mg/mL

p40(Rabbit PAb) Antibody

BNC940375-500 500uL
EUR 544
Description: Primary antibody against p40(Rabbit PAb), CF594 conjugate, Concentration: 0.1mg/mL

CD3e(Rabbit PAb) Antibody

BNC940385-100 100uL
EUR 199
Description: Primary antibody against CD3e(Rabbit PAb), CF594 conjugate, Concentration: 0.1mg/mL

CD3e(Rabbit PAb) Antibody

BNC940385-500 500uL
EUR 544
Description: Primary antibody against CD3e(Rabbit PAb), CF594 conjugate, Concentration: 0.1mg/mL

CD8a(Rabbit PAb) Antibody

BNC940386-100 100uL
EUR 199
Description: Primary antibody against CD8a(Rabbit PAb), CF594 conjugate, Concentration: 0.1mg/mL

CD8a(Rabbit PAb) Antibody

BNC940386-500 500uL
EUR 544
Description: Primary antibody against CD8a(Rabbit PAb), CF594 conjugate, Concentration: 0.1mg/mL

TIMP3(Rabbit PAb) Antibody

BNC940408-100 100uL
EUR 199
Description: Primary antibody against TIMP3(Rabbit PAb), CF594 conjugate, Concentration: 0.1mg/mL

TIMP3(Rabbit PAb) Antibody

BNC940408-500 500uL
EUR 544
Description: Primary antibody against TIMP3(Rabbit PAb), CF594 conjugate, Concentration: 0.1mg/mL

p40(Rabbit PAb) Antibody

BNCP0375-250 250uL
EUR 383
Description: Primary antibody against p40(Rabbit PAb), PerCP conjugate, Concentration: 0.1mg/mL

CD3e(Rabbit PAb) Antibody

BNCP0385-250 250uL
EUR 383
Description: Primary antibody against CD3e(Rabbit PAb), PerCP conjugate, Concentration: 0.1mg/mL

CD8a(Rabbit PAb) Antibody

BNCP0386-250 250uL
EUR 383
Description: Primary antibody against CD8a(Rabbit PAb), PerCP conjugate, Concentration: 0.1mg/mL

TIMP3(Rabbit PAb) Antibody

BNCP0408-250 250uL
EUR 383
Description: Primary antibody against TIMP3(Rabbit PAb), PerCP conjugate, Concentration: 0.1mg/mL

p40(Rabbit PAb) Antibody

BNC040375-100 100uL
EUR 199
Description: Primary antibody against p40(Rabbit PAb), CF405S conjugate, Concentration: 0.1mg/mL

p40(Rabbit PAb) Antibody

BNC040375-500 500uL
EUR 544
Description: Primary antibody against p40(Rabbit PAb), CF405S conjugate, Concentration: 0.1mg/mL

CD3e(Rabbit PAb) Antibody

BNC040385-100 100uL
EUR 199
Description: Primary antibody against CD3e(Rabbit PAb), CF405S conjugate, Concentration: 0.1mg/mL

CD3e(Rabbit PAb) Antibody

BNC040385-500 500uL
EUR 544
Description: Primary antibody against CD3e(Rabbit PAb), CF405S conjugate, Concentration: 0.1mg/mL

CD8a(Rabbit PAb) Antibody

BNC040386-100 100uL
EUR 199
Description: Primary antibody against CD8a(Rabbit PAb), CF405S conjugate, Concentration: 0.1mg/mL

CD8a(Rabbit PAb) Antibody

BNC040386-500 500uL
EUR 544
Description: Primary antibody against CD8a(Rabbit PAb), CF405S conjugate, Concentration: 0.1mg/mL

TIMP3(Rabbit PAb) Antibody

BNC040408-100 100uL
EUR 199
Description: Primary antibody against TIMP3(Rabbit PAb), CF405S conjugate, Concentration: 0.1mg/mL

TIMP3(Rabbit PAb) Antibody

BNC040408-500 500uL
EUR 544
Description: Primary antibody against TIMP3(Rabbit PAb), CF405S conjugate, Concentration: 0.1mg/mL

p40(Rabbit PAb) Antibody

BNC050375-100 100uL
EUR 199
Description: Primary antibody against p40(Rabbit PAb), CF405M conjugate, Concentration: 0.1mg/mL

p40(Rabbit PAb) Antibody

BNC050375-500 500uL
EUR 544
Description: Primary antibody against p40(Rabbit PAb), CF405M conjugate, Concentration: 0.1mg/mL

CD3e(Rabbit PAb) Antibody

BNC050385-100 100uL
EUR 199
Description: Primary antibody against CD3e(Rabbit PAb), CF405M conjugate, Concentration: 0.1mg/mL

CD3e(Rabbit PAb) Antibody

BNC050385-500 500uL
EUR 544
Description: Primary antibody against CD3e(Rabbit PAb), CF405M conjugate, Concentration: 0.1mg/mL

CD8a(Rabbit PAb) Antibody

BNC050386-100 100uL
EUR 199
Description: Primary antibody against CD8a(Rabbit PAb), CF405M conjugate, Concentration: 0.1mg/mL

CD8a(Rabbit PAb) Antibody

BNC050386-500 500uL
EUR 544
Description: Primary antibody against CD8a(Rabbit PAb), CF405M conjugate, Concentration: 0.1mg/mL

TIMP3(Rabbit PAb) Antibody

BNC050408-100 100uL
EUR 199
Description: Primary antibody against TIMP3(Rabbit PAb), CF405M conjugate, Concentration: 0.1mg/mL

TIMP3(Rabbit PAb) Antibody

BNC050408-500 500uL
EUR 544
Description: Primary antibody against TIMP3(Rabbit PAb), CF405M conjugate, Concentration: 0.1mg/mL

Met Rabbit Polyclonal Antibody

ABP57458-003ml 0.03ml
EUR 158
Description: A polyclonal antibody for detection of Met from Human, Mouse, Rat. This Met antibody is for IHC-P. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen recombinant protein of Met of MET

Met Rabbit Polyclonal Antibody

ABP57458-01ml 0.1ml
EUR 289
Description: A polyclonal antibody for detection of Met from Human, Mouse, Rat. This Met antibody is for IHC-P. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen recombinant protein of Met of MET

Met Rabbit Polyclonal Antibody

ABP57458-02ml 0.2ml
EUR 414
Description: A polyclonal antibody for detection of Met from Human, Mouse, Rat. This Met antibody is for IHC-P. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen recombinant protein of Met of MET

VEGF Rabbit Polyclonal Antibody

ABP57460-003ml 0.03ml
EUR 158
Description: A polyclonal antibody for detection of VEGF from Human, Mouse, Rat. This VEGF antibody is for IHC-P. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen recombinant protein of VEGF of VEGFA

VEGF Rabbit Polyclonal Antibody

ABP57460-01ml 0.1ml
EUR 289
Description: A polyclonal antibody for detection of VEGF from Human, Mouse, Rat. This VEGF antibody is for IHC-P. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen recombinant protein of VEGF of VEGFA

VEGF Rabbit Polyclonal Antibody

ABP57460-02ml 0.2ml
EUR 414
Description: A polyclonal antibody for detection of VEGF from Human, Mouse, Rat. This VEGF antibody is for IHC-P. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen recombinant protein of VEGF of VEGFA

CD10 Rabbit Polyclonal Antibody

ABP57461-003ml 0.03ml
EUR 158
Description: A polyclonal antibody for detection of CD10 from Human, Mouse, Rat. This CD10 antibody is for IHC-P. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen recombinant protein of CD10 of MME

CD10 Rabbit Polyclonal Antibody

ABP57461-01ml 0.1ml
EUR 289
Description: A polyclonal antibody for detection of CD10 from Human, Mouse, Rat. This CD10 antibody is for IHC-P. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen recombinant protein of CD10 of MME

CD10 Rabbit Polyclonal Antibody

ABP57461-02ml 0.2ml
EUR 414
Description: A polyclonal antibody for detection of CD10 from Human, Mouse, Rat. This CD10 antibody is for IHC-P. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen recombinant protein of CD10 of MME

NM23A Rabbit Polyclonal Antibody

ABP57462-003ml 0.03ml
EUR 158
Description: A polyclonal antibody for detection of NM23A from Human, Mouse, Rat. This NM23A antibody is for IHC-P. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen recombinant protein of NM23A of NME1

NM23A Rabbit Polyclonal Antibody

ABP57462-01ml 0.1ml
EUR 289
Description: A polyclonal antibody for detection of NM23A from Human, Mouse, Rat. This NM23A antibody is for IHC-P. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen recombinant protein of NM23A of NME1

NM23A Rabbit Polyclonal Antibody

ABP57462-02ml 0.2ml
EUR 414
Description: A polyclonal antibody for detection of NM23A from Human, Mouse, Rat. This NM23A antibody is for IHC-P. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen recombinant protein of NM23A of NME1

ATM Rabbit Polyclonal Antibody

ABP57463-003ml 0.03ml
EUR 158
Description: A polyclonal antibody for detection of ATM from Human, Mouse, Rat. This ATM antibody is for IHC-P. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen recombinant protein of ATM of ATM

ATM Rabbit Polyclonal Antibody

ABP57463-01ml 0.1ml
EUR 289
Description: A polyclonal antibody for detection of ATM from Human, Mouse, Rat. This ATM antibody is for IHC-P. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen recombinant protein of ATM of ATM
The lab-based Abbott diagnostics SARS-CoV-2 IgG assay proved to be the assay with one of the best constructive and detrimental predictive worth, and general accuracy. The POC Nal von Minden GmbH and Biozek assays additionally carried out nicely. Conclusion Our analysis demonstrates the variations in efficiency of a number of commercially out there SARS-CoV-2 antibody assays. These findings determine the restrictions of some serological exams for SARS-CoV-2. This data will assist inform take a look at choice and should have explicit relevance to suppliers working past accredited laboratories.

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