The extreme acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein is the principle goal for neutralizing antibodies. These antibodies might be elicited by means of immunization or passively transferred as therapeutics within the type of convalescent-phase sera or monoclonal antibodies (MAbs). Potently neutralizing antibodies are anticipated to confer safety; nevertheless, it’s unclear whether or not weakly neutralizing antibodies contribute to safety.
Additionally, their mechanism of motion in vivo is incompletely understood. Right here, we show that 2B04, an antibody with an ultrapotent neutralizing exercise (50% inhibitory focus [IC50] of 0.04 μg/ml), protects hamsters towards SARS-CoV-2 in a prophylactic and therapeutic an infection mannequin. Safety is related to diminished weight reduction and viral hundreds in nasal turbinates and lungs after problem.
MAb 2B04 additionally blocked aerosol transmission of the virus to naive contacts. We subsequent examined three extra MAbs (2C02, 2C03, and 2E06), recognizing distinct epitopes inside the receptor binding area of spike protein that possess both minimal (2C02 and 2E06, IC50 > 20 μg/ml) or weak (2C03, IC50 of 5 μg/ml) virus neutralization capability in vitro. Solely 2C03 protected Syrian hamsters from weight reduction and diminished lung viral load after SARS-CoV-2 an infection.
Lastly, we demonstrated that Fc-Fc receptor interactions weren’t required for cover when 2B04 and 2C03 have been administered prophylactically. These findings inform the mechanism of safety and help the rational improvement of antibody-mediated safety towards SARS-CoV-2 infections. IMPORTANCE The continued coronavirus illness 2019 (COVID-19) pandemic, brought on by SARS-CoV-2, has resulted within the lack of thousands and thousands of lives. Protected and efficient vaccines are thought of the last word treatment for the worldwide social and financial disruption brought on by the pandemic.
Nevertheless, an intensive understanding of the immune correlates of safety towards this virus is missing. Right here, we characterised 4 completely different monoclonal antibodies and evaluated their capability to forestall or deal with SARS-CoV-2 an infection in Syrian hamsters. These antibodies various of their capability to neutralize the virus in vitro. Prophylactic administration of potent and weakly neutralizing antibodies protected towards SARS-CoV-2 an infection, and this impact was Fc receptor unbiased.
The potent neutralizing antibody additionally had therapeutic efficacy and eradicated onward aerosol transmission. In distinction, minimally neutralizing antibodies offered no safety towards an infection with SARS-CoV-2 in Syrian hamsters. Mixed, these research spotlight the importance of weakly neutralizing antibodies within the safety towards SARS-CoV-2 an infection and related illness.
Fast and quantitative detection of SARS-CoV-2 IgG antibody in serum utilizing optofluidic point-of-care testing fluorescence biosensor
The COVID-19 pandemic brings unprecedented disaster for public well being and economics on the earth. Detecting particular antibodies to SARS-CoV-2 is a strong complement for the analysis of COVID-19 and is essential for epidemiological research and vaccine validations. Herein, a speedy and quantitative detection methodology of anti-SARS-CoV-2 IgG antibody was constructed based mostly on the optofluidic point-of-care testing fluorescence biosensor.
With out difficult steps wanted, the moveable system is appropriate for on-site delicate dedication of anti-SARS-CoV-2 IgG antibody in serum. Beneath the optimum situations, the entire detection process is about 25 min with a detection restrict of 12.5 ng/mL that may nicely meet the diagnostic necessities. The tactic was not clearly affected by IgM and serum matrix and demonstrated to have good stability and reliability in actual pattern evaluation.
In comparison with ELISA take a look at outcomes, the proposed methodology reveals a number of benefits together with wider measurement vary and simpler operation. The tactic supplies a common platform for speedy and quantitative evaluation of different associated biomarkers, which is of significance for the prevention and management of COVID-19 pandemic.
Non-Genetic Technology of Antibody Conjugates Based mostly on Chemoenzymatic Tyrosine Click on Chemistry
The provision of instruments to generate homogeneous and secure antibody conjugates with out recombinant DNA know-how is a precious asset in fields spanning from in vitro diagnostics to in vivo imaging and therapeutics. We current right here a common method for the conjugation to human IgG1 antibodies, by using an easy two-stage protocol based mostly on antibody deglycosylation adopted by tyrosinase-mediated ortho-quinone strain-promoted click on chemistry. The know-how is validated by the environment friendly and clear era of extremely potent DAR2 and DAR4 antibody-drug conjugates (ADCs) with cytotoxic payloads MMAE or PBD dimer, and their in vitro analysis.
Section 1a/b Examine of Monoclonal Antibody CAEL-101 (11-1F4) in Sufferers with AL Amyloidosis
Systemic immunoglobulin light-chain (AL) amyloidosis is characterised by pathologic deposition of immunoglobulin gentle chains as amyloid fibrils in very important organs, resulting in organ impairment and eventual dying. That the method is reversible was evidenced in an in vivo experimental mannequin through which fibril-reactive chimeric monoclonal antibody (mAb) 11-1F4 straight focused human light-chain amyloid deposits and effected their elimination through a phagocyte-mediated response.
To find out tolerability and potential amyloidolytic impact of this agent (now designated mAb CAEL-101), we carried out a part 1a/b research involving 27 sufferers, most of whom had manifestations of organ involvement. This was an open label research through which part 1a sufferers acquired mAb CAEL-101 as a single intravenous infusion, with escalating dose ranges from 0.5 mg/m2 to 500 mg/m2 to determine the most tolerated dose (MTD). In part 1b, the antibody was administered as a graded sequence of 4 weekly infusions.
For each phases, there have been no drug-related critical antagonistic occasions or dose-limiting toxicities amongst recipients and the MTD was not reached. Majority of sufferers had deep hematologic responses however persistent organ illness previous to remedy. Fifteen of 24 sufferers (63%) who manifested cardiac, renal, hepatic, gastrointestinal, or smooth tissue involvement had a therapeutic response to mAb CAEL-101 as evidenced by serum biomarkers or goal imaging modalities with median time to response of three weeks. Infusions of mAb CAEL-101 have been well-tolerated and, for almost all, resulted in improved organ perform, notably for these with cardiac impairment.
A Comparability of the Efficiency of SARS-CoV-2 Antibody Assays in Healthcare Staff with COVID-19
Goals Since its emergence, vital curiosity surrounds the usage of SARS-CoV-2 serological exams as a substitute or as an adjunct to molecular testing. Nevertheless, given the velocity of this pandemic, paralleled with the stress to develop and supply serological exams in an expediated method, not each assay has undergone the rigorous analysis that’s normally related to medical diagnostic assays.
We aimed to look at the efficiency of a number of commercially out there SARS-CoV-2 IgG antibody assays amongst members with confirmed COVID-19 illness and detrimental controls. Strategies Serum taken between day 17 and day 40 publish onset of signs from 41 healthcare employees with RT-PCR confirmed COVID-19 illness, and pre-pandemic serum from 20 detrimental controls, have been examined for the presence of SARS-CoV-2 IgG utilizing 7 completely different assays together with point-of-care (POC) and laboratory-based assays. Outcomes Assay efficiency various.
 Rabbit Albumin Antibody |
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| 40150-05011 | AssayPro | 150 ug | EUR 217 |
 Anti-Rabbit antibody |
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| STJ11100323 | St John's Laboratory | 100 µl | EUR 277 |
 Antibody) p40(Rabbit PAb) Antibody |
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| BNC610375-100 | Biotium | 100uL | EUR 199 |
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Description: Primary antibody against p40(Rabbit PAb), CF660R conjugate, Concentration: 0.1mg/mL |
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p40(Rabbit PAb) Antibody |
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| BNC610375-500 | Biotium | 500uL | EUR 544 |
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Description: Primary antibody against p40(Rabbit PAb), CF660R conjugate, Concentration: 0.1mg/mL |
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 Antibody) CD3e(Rabbit PAb) Antibody |
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| BNC610385-100 | Biotium | 100uL | EUR 199 |
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Description: Primary antibody against CD3e(Rabbit PAb), CF660R conjugate, Concentration: 0.1mg/mL |
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CD3e(Rabbit PAb) Antibody |
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| BNC610385-500 | Biotium | 500uL | EUR 544 |
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Description: Primary antibody against CD3e(Rabbit PAb), CF660R conjugate, Concentration: 0.1mg/mL |
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 Antibody) CD8a(Rabbit PAb) Antibody |
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| BNC610386-100 | Biotium | 100uL | EUR 199 |
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Description: Primary antibody against CD8a(Rabbit PAb), CF660R conjugate, Concentration: 0.1mg/mL |
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CD8a(Rabbit PAb) Antibody |
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| BNC610386-500 | Biotium | 500uL | EUR 544 |
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Description: Primary antibody against CD8a(Rabbit PAb), CF660R conjugate, Concentration: 0.1mg/mL |
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 Antibody) TIMP3(Rabbit PAb) Antibody |
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| BNC610408-100 | Biotium | 100uL | EUR 199 |
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Description: Primary antibody against TIMP3(Rabbit PAb), CF660R conjugate, Concentration: 0.1mg/mL |
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TIMP3(Rabbit PAb) Antibody |
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| BNC610408-500 | Biotium | 500uL | EUR 544 |
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Description: Primary antibody against TIMP3(Rabbit PAb), CF660R conjugate, Concentration: 0.1mg/mL |
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p40(Rabbit PAb) Antibody |
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| BNC680375-100 | Biotium | 100uL | EUR 199 |
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Description: Primary antibody against p40(Rabbit PAb), CF568 conjugate, Concentration: 0.1mg/mL |
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p40(Rabbit PAb) Antibody |
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| BNC680375-500 | Biotium | 500uL | EUR 544 |
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Description: Primary antibody against p40(Rabbit PAb), CF568 conjugate, Concentration: 0.1mg/mL |
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CD3e(Rabbit PAb) Antibody |
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| BNC680385-100 | Biotium | 100uL | EUR 199 |
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Description: Primary antibody against CD3e(Rabbit PAb), CF568 conjugate, Concentration: 0.1mg/mL |
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CD3e(Rabbit PAb) Antibody |
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| BNC680385-500 | Biotium | 500uL | EUR 544 |
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Description: Primary antibody against CD3e(Rabbit PAb), CF568 conjugate, Concentration: 0.1mg/mL |
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CD8a(Rabbit PAb) Antibody |
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| BNC680386-100 | Biotium | 100uL | EUR 199 |
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Description: Primary antibody against CD8a(Rabbit PAb), CF568 conjugate, Concentration: 0.1mg/mL |
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CD8a(Rabbit PAb) Antibody |
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| BNC680386-500 | Biotium | 500uL | EUR 544 |
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Description: Primary antibody against CD8a(Rabbit PAb), CF568 conjugate, Concentration: 0.1mg/mL |
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TIMP3(Rabbit PAb) Antibody |
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| BNC680408-100 | Biotium | 100uL | EUR 199 |
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Description: Primary antibody against TIMP3(Rabbit PAb), CF568 conjugate, Concentration: 0.1mg/mL |
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TIMP3(Rabbit PAb) Antibody |
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| BNC680408-500 | Biotium | 500uL | EUR 544 |
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Description: Primary antibody against TIMP3(Rabbit PAb), CF568 conjugate, Concentration: 0.1mg/mL |
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p40(Rabbit PAb) Antibody |
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| BNC400375-100 | Biotium | 100uL | EUR 199 |
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Description: Primary antibody against p40(Rabbit PAb), CF640R conjugate, Concentration: 0.1mg/mL |
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p40(Rabbit PAb) Antibody |
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| BNC400375-500 | Biotium | 500uL | EUR 544 |
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Description: Primary antibody against p40(Rabbit PAb), CF640R conjugate, Concentration: 0.1mg/mL |
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CD3e(Rabbit PAb) Antibody |
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| BNC400385-100 | Biotium | 100uL | EUR 199 |
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Description: Primary antibody against CD3e(Rabbit PAb), CF640R conjugate, Concentration: 0.1mg/mL |
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CD3e(Rabbit PAb) Antibody |
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| BNC400385-500 | Biotium | 500uL | EUR 544 |
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Description: Primary antibody against CD3e(Rabbit PAb), CF640R conjugate, Concentration: 0.1mg/mL |
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CD8a(Rabbit PAb) Antibody |
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| BNC400386-100 | Biotium | 100uL | EUR 199 |
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Description: Primary antibody against CD8a(Rabbit PAb), CF640R conjugate, Concentration: 0.1mg/mL |
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CD8a(Rabbit PAb) Antibody |
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| BNC400386-500 | Biotium | 500uL | EUR 544 |
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Description: Primary antibody against CD8a(Rabbit PAb), CF640R conjugate, Concentration: 0.1mg/mL |
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TIMP3(Rabbit PAb) Antibody |
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| BNC400408-100 | Biotium | 100uL | EUR 199 |
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Description: Primary antibody against TIMP3(Rabbit PAb), CF640R conjugate, Concentration: 0.1mg/mL |
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TIMP3(Rabbit PAb) Antibody |
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| BNC400408-500 | Biotium | 500uL | EUR 544 |
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Description: Primary antibody against TIMP3(Rabbit PAb), CF640R conjugate, Concentration: 0.1mg/mL |
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p40(Rabbit PAb) Antibody |
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| BNC430375-100 | Biotium | 100uL | EUR 199 |
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Description: Primary antibody against p40(Rabbit PAb), CF543 conjugate, Concentration: 0.1mg/mL |
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p40(Rabbit PAb) Antibody |
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| BNC430375-500 | Biotium | 500uL | EUR 544 |
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Description: Primary antibody against p40(Rabbit PAb), CF543 conjugate, Concentration: 0.1mg/mL |
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CD3e(Rabbit PAb) Antibody |
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| BNC430385-100 | Biotium | 100uL | EUR 199 |
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Description: Primary antibody against CD3e(Rabbit PAb), CF543 conjugate, Concentration: 0.1mg/mL |
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CD3e(Rabbit PAb) Antibody |
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| BNC430385-500 | Biotium | 500uL | EUR 544 |
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Description: Primary antibody against CD3e(Rabbit PAb), CF543 conjugate, Concentration: 0.1mg/mL |
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CD8a(Rabbit PAb) Antibody |
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| BNC430386-100 | Biotium | 100uL | EUR 199 |
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Description: Primary antibody against CD8a(Rabbit PAb), CF543 conjugate, Concentration: 0.1mg/mL |
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CD8a(Rabbit PAb) Antibody |
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| BNC430386-500 | Biotium | 500uL | EUR 544 |
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Description: Primary antibody against CD8a(Rabbit PAb), CF543 conjugate, Concentration: 0.1mg/mL |
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TIMP3(Rabbit PAb) Antibody |
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| BNC430408-100 | Biotium | 100uL | EUR 199 |
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Description: Primary antibody against TIMP3(Rabbit PAb), CF543 conjugate, Concentration: 0.1mg/mL |
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TIMP3(Rabbit PAb) Antibody |
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| BNC430408-500 | Biotium | 500uL | EUR 544 |
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Description: Primary antibody against TIMP3(Rabbit PAb), CF543 conjugate, Concentration: 0.1mg/mL |
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p40(Rabbit PAb) Antibody |
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| BNC550375-100 | Biotium | 100uL | EUR 199 |
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Description: Primary antibody against p40(Rabbit PAb), CF555 conjugate, Concentration: 0.1mg/mL |
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p40(Rabbit PAb) Antibody |
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| BNC550375-500 | Biotium | 500uL | EUR 544 |
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Description: Primary antibody against p40(Rabbit PAb), CF555 conjugate, Concentration: 0.1mg/mL |
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CD3e(Rabbit PAb) Antibody |
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| BNC550385-100 | Biotium | 100uL | EUR 199 |
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Description: Primary antibody against CD3e(Rabbit PAb), CF555 conjugate, Concentration: 0.1mg/mL |
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CD3e(Rabbit PAb) Antibody |
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| BNC550385-500 | Biotium | 500uL | EUR 544 |
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Description: Primary antibody against CD3e(Rabbit PAb), CF555 conjugate, Concentration: 0.1mg/mL |
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CD8a(Rabbit PAb) Antibody |
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| BNC550386-100 | Biotium | 100uL | EUR 199 |
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Description: Primary antibody against CD8a(Rabbit PAb), CF555 conjugate, Concentration: 0.1mg/mL |
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CD8a(Rabbit PAb) Antibody |
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| BNC550386-500 | Biotium | 500uL | EUR 544 |
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Description: Primary antibody against CD8a(Rabbit PAb), CF555 conjugate, Concentration: 0.1mg/mL |
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TIMP3(Rabbit PAb) Antibody |
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| BNC550408-100 | Biotium | 100uL | EUR 199 |
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Description: Primary antibody against TIMP3(Rabbit PAb), CF555 conjugate, Concentration: 0.1mg/mL |
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TIMP3(Rabbit PAb) Antibody |
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| BNC550408-500 | Biotium | 500uL | EUR 544 |
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Description: Primary antibody against TIMP3(Rabbit PAb), CF555 conjugate, Concentration: 0.1mg/mL |
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p40(Rabbit PAb) Antibody |
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| BNC040375-100 | Biotium | 100uL | EUR 199 |
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Description: Primary antibody against p40(Rabbit PAb), CF405S conjugate, Concentration: 0.1mg/mL |
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p40(Rabbit PAb) Antibody |
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| BNC040375-500 | Biotium | 500uL | EUR 544 |
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Description: Primary antibody against p40(Rabbit PAb), CF405S conjugate, Concentration: 0.1mg/mL |
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CD3e(Rabbit PAb) Antibody |
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| BNC040385-100 | Biotium | 100uL | EUR 199 |
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Description: Primary antibody against CD3e(Rabbit PAb), CF405S conjugate, Concentration: 0.1mg/mL |
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CD3e(Rabbit PAb) Antibody |
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| BNC040385-500 | Biotium | 500uL | EUR 544 |
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Description: Primary antibody against CD3e(Rabbit PAb), CF405S conjugate, Concentration: 0.1mg/mL |
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CD8a(Rabbit PAb) Antibody |
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| BNC040386-100 | Biotium | 100uL | EUR 199 |
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Description: Primary antibody against CD8a(Rabbit PAb), CF405S conjugate, Concentration: 0.1mg/mL |
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CD8a(Rabbit PAb) Antibody |
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| BNC040386-500 | Biotium | 500uL | EUR 544 |
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Description: Primary antibody against CD8a(Rabbit PAb), CF405S conjugate, Concentration: 0.1mg/mL |
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TIMP3(Rabbit PAb) Antibody |
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| BNC040408-100 | Biotium | 100uL | EUR 199 |
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Description: Primary antibody against TIMP3(Rabbit PAb), CF405S conjugate, Concentration: 0.1mg/mL |
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TIMP3(Rabbit PAb) Antibody |
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| BNC040408-500 | Biotium | 500uL | EUR 544 |
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Description: Primary antibody against TIMP3(Rabbit PAb), CF405S conjugate, Concentration: 0.1mg/mL |
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p40(Rabbit PAb) Antibody |
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| BNC050375-100 | Biotium | 100uL | EUR 199 |
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Description: Primary antibody against p40(Rabbit PAb), CF405M conjugate, Concentration: 0.1mg/mL |
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p40(Rabbit PAb) Antibody |
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| BNC050375-500 | Biotium | 500uL | EUR 544 |
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Description: Primary antibody against p40(Rabbit PAb), CF405M conjugate, Concentration: 0.1mg/mL |
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CD3e(Rabbit PAb) Antibody |
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| BNC050385-100 | Biotium | 100uL | EUR 199 |
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Description: Primary antibody against CD3e(Rabbit PAb), CF405M conjugate, Concentration: 0.1mg/mL |
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CD3e(Rabbit PAb) Antibody |
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| BNC050385-500 | Biotium | 500uL | EUR 544 |
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Description: Primary antibody against CD3e(Rabbit PAb), CF405M conjugate, Concentration: 0.1mg/mL |
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CD8a(Rabbit PAb) Antibody |
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| BNC050386-100 | Biotium | 100uL | EUR 199 |
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Description: Primary antibody against CD8a(Rabbit PAb), CF405M conjugate, Concentration: 0.1mg/mL |
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CD8a(Rabbit PAb) Antibody |
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| BNC050386-500 | Biotium | 500uL | EUR 544 |
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Description: Primary antibody against CD8a(Rabbit PAb), CF405M conjugate, Concentration: 0.1mg/mL |
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TIMP3(Rabbit PAb) Antibody |
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| BNC050408-100 | Biotium | 100uL | EUR 199 |
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Description: Primary antibody against TIMP3(Rabbit PAb), CF405M conjugate, Concentration: 0.1mg/mL |
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TIMP3(Rabbit PAb) Antibody |
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| BNC050408-500 | Biotium | 500uL | EUR 544 |
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Description: Primary antibody against TIMP3(Rabbit PAb), CF405M conjugate, Concentration: 0.1mg/mL |
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p40(Rabbit PAb) Antibody |
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| BNC470375-100 | Biotium | 100uL | EUR 199 |
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Description: Primary antibody against p40(Rabbit PAb), CF647 conjugate, Concentration: 0.1mg/mL |
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p40(Rabbit PAb) Antibody |
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| BNC470375-500 | Biotium | 500uL | EUR 544 |
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Description: Primary antibody against p40(Rabbit PAb), CF647 conjugate, Concentration: 0.1mg/mL |
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CD3e(Rabbit PAb) Antibody |
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| BNC470385-100 | Biotium | 100uL | EUR 199 |
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Description: Primary antibody against CD3e(Rabbit PAb), CF647 conjugate, Concentration: 0.1mg/mL |
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CD3e(Rabbit PAb) Antibody |
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| BNC470385-500 | Biotium | 500uL | EUR 544 |
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Description: Primary antibody against CD3e(Rabbit PAb), CF647 conjugate, Concentration: 0.1mg/mL |
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CD8a(Rabbit PAb) Antibody |
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| BNC470386-100 | Biotium | 100uL | EUR 199 |
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Description: Primary antibody against CD8a(Rabbit PAb), CF647 conjugate, Concentration: 0.1mg/mL |
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CD8a(Rabbit PAb) Antibody |
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| BNC470386-500 | Biotium | 500uL | EUR 544 |
|
Description: Primary antibody against CD8a(Rabbit PAb), CF647 conjugate, Concentration: 0.1mg/mL |
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TIMP3(Rabbit PAb) Antibody |
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| BNC470408-100 | Biotium | 100uL | EUR 199 |
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Description: Primary antibody against TIMP3(Rabbit PAb), CF647 conjugate, Concentration: 0.1mg/mL |
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TIMP3(Rabbit PAb) Antibody |
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| BNC470408-500 | Biotium | 500uL | EUR 544 |
|
Description: Primary antibody against TIMP3(Rabbit PAb), CF647 conjugate, Concentration: 0.1mg/mL |
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p40(Rabbit PAb) Antibody |
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| BNUM0375-50 | Biotium | 50uL | EUR 395 |
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Description: Primary antibody against p40(Rabbit PAb), 1mg/mL |
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CD3e(Rabbit PAb) Antibody |
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| BNUM0385-50 | Biotium | 50uL | EUR 395 |
|
Description: Primary antibody against CD3e(Rabbit PAb), 1mg/mL |
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CD8a(Rabbit PAb) Antibody |
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| BNUM0386-50 | Biotium | 50uL | EUR 395 |
|
Description: Primary antibody against CD8a(Rabbit PAb), 1mg/mL |
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TIMP3(Rabbit PAb) Antibody |
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| BNUM0408-50 | Biotium | 50uL | EUR 395 |
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Description: Primary antibody against TIMP3(Rabbit PAb), 1mg/mL |
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p40(Rabbit PAb) Antibody |
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| BNC700375-100 | Biotium | 100uL | EUR 199 |
|
Description: Primary antibody against p40(Rabbit PAb), CF770 conjugate, Concentration: 0.1mg/mL |
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p40(Rabbit PAb) Antibody |
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| BNC700375-500 | Biotium | 500uL | EUR 544 |
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Description: Primary antibody against p40(Rabbit PAb), CF770 conjugate, Concentration: 0.1mg/mL |
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CD3e(Rabbit PAb) Antibody |
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| BNC700385-100 | Biotium | 100uL | EUR 199 |
|
Description: Primary antibody against CD3e(Rabbit PAb), CF770 conjugate, Concentration: 0.1mg/mL |
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CD3e(Rabbit PAb) Antibody |
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| BNC700385-500 | Biotium | 500uL | EUR 544 |
|
Description: Primary antibody against CD3e(Rabbit PAb), CF770 conjugate, Concentration: 0.1mg/mL |
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CD8a(Rabbit PAb) Antibody |
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| BNC700386-100 | Biotium | 100uL | EUR 199 |
|
Description: Primary antibody against CD8a(Rabbit PAb), CF770 conjugate, Concentration: 0.1mg/mL |
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CD8a(Rabbit PAb) Antibody |
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| BNC700386-500 | Biotium | 500uL | EUR 544 |
|
Description: Primary antibody against CD8a(Rabbit PAb), CF770 conjugate, Concentration: 0.1mg/mL |
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TIMP3(Rabbit PAb) Antibody |
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| BNC700408-100 | Biotium | 100uL | EUR 199 |
|
Description: Primary antibody against TIMP3(Rabbit PAb), CF770 conjugate, Concentration: 0.1mg/mL |
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TIMP3(Rabbit PAb) Antibody |
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| BNC700408-500 | Biotium | 500uL | EUR 544 |
|
Description: Primary antibody against TIMP3(Rabbit PAb), CF770 conjugate, Concentration: 0.1mg/mL |
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p40(Rabbit PAb) Antibody |
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| BNC940375-100 | Biotium | 100uL | EUR 199 |
|
Description: Primary antibody against p40(Rabbit PAb), CF594 conjugate, Concentration: 0.1mg/mL |
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p40(Rabbit PAb) Antibody |
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| BNC940375-500 | Biotium | 500uL | EUR 544 |
|
Description: Primary antibody against p40(Rabbit PAb), CF594 conjugate, Concentration: 0.1mg/mL |
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CD3e(Rabbit PAb) Antibody |
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| BNC940385-100 | Biotium | 100uL | EUR 199 |
|
Description: Primary antibody against CD3e(Rabbit PAb), CF594 conjugate, Concentration: 0.1mg/mL |
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CD3e(Rabbit PAb) Antibody |
|||
| BNC940385-500 | Biotium | 500uL | EUR 544 |
|
Description: Primary antibody against CD3e(Rabbit PAb), CF594 conjugate, Concentration: 0.1mg/mL |
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CD8a(Rabbit PAb) Antibody |
|||
| BNC940386-100 | Biotium | 100uL | EUR 199 |
|
Description: Primary antibody against CD8a(Rabbit PAb), CF594 conjugate, Concentration: 0.1mg/mL |
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CD8a(Rabbit PAb) Antibody |
|||
| BNC940386-500 | Biotium | 500uL | EUR 544 |
|
Description: Primary antibody against CD8a(Rabbit PAb), CF594 conjugate, Concentration: 0.1mg/mL |
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TIMP3(Rabbit PAb) Antibody |
|||
| BNC940408-100 | Biotium | 100uL | EUR 199 |
|
Description: Primary antibody against TIMP3(Rabbit PAb), CF594 conjugate, Concentration: 0.1mg/mL |
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TIMP3(Rabbit PAb) Antibody |
|||
| BNC940408-500 | Biotium | 500uL | EUR 544 |
|
Description: Primary antibody against TIMP3(Rabbit PAb), CF594 conjugate, Concentration: 0.1mg/mL |
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p40(Rabbit PAb) Antibody |
|||
| BNCH0375-100 | Biotium | 100uL | EUR 199 |
|
Description: Primary antibody against p40(Rabbit PAb), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL |
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p40(Rabbit PAb) Antibody |
|||
| BNCH0375-500 | Biotium | 500uL | EUR 544 |
|
Description: Primary antibody against p40(Rabbit PAb), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL |
|||
CD3e(Rabbit PAb) Antibody |
|||
| BNCH0385-100 | Biotium | 100uL | EUR 199 |
|
Description: Primary antibody against CD3e(Rabbit PAb), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL |
|||
CD3e(Rabbit PAb) Antibody |
|||
| BNCH0385-500 | Biotium | 500uL | EUR 544 |
|
Description: Primary antibody against CD3e(Rabbit PAb), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL |
|||
CD8a(Rabbit PAb) Antibody |
|||
| BNCH0386-100 | Biotium | 100uL | EUR 199 |
|
Description: Primary antibody against CD8a(Rabbit PAb), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL |
|||
CD8a(Rabbit PAb) Antibody |
|||
| BNCH0386-500 | Biotium | 500uL | EUR 544 |
|
Description: Primary antibody against CD8a(Rabbit PAb), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL |
|||
TIMP3(Rabbit PAb) Antibody |
|||
| BNCH0408-100 | Biotium | 100uL | EUR 199 |
|
Description: Primary antibody against TIMP3(Rabbit PAb), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL |
|||
TIMP3(Rabbit PAb) Antibody |
|||
| BNCH0408-500 | Biotium | 500uL | EUR 544 |
|
Description: Primary antibody against TIMP3(Rabbit PAb), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL |
|||
p40(Rabbit PAb) Antibody |
|||
| BNC800375-100 | Biotium | 100uL | EUR 199 |
|
Description: Primary antibody against p40(Rabbit PAb), CF680 conjugate, Concentration: 0.1mg/mL |
|||
p40(Rabbit PAb) Antibody |
|||
| BNC800375-500 | Biotium | 500uL | EUR 544 |
|
Description: Primary antibody against p40(Rabbit PAb), CF680 conjugate, Concentration: 0.1mg/mL |
|||
CD3e(Rabbit PAb) Antibody |
|||
| BNC800385-100 | Biotium | 100uL | EUR 199 |
|
Description: Primary antibody against CD3e(Rabbit PAb), CF680 conjugate, Concentration: 0.1mg/mL |
|||
CD3e(Rabbit PAb) Antibody |
|||
| BNC800385-500 | Biotium | 500uL | EUR 544 |
|
Description: Primary antibody against CD3e(Rabbit PAb), CF680 conjugate, Concentration: 0.1mg/mL |
|||
CD8a(Rabbit PAb) Antibody |
|||
| BNC800386-100 | Biotium | 100uL | EUR 199 |
|
Description: Primary antibody against CD8a(Rabbit PAb), CF680 conjugate, Concentration: 0.1mg/mL |
|||
CD8a(Rabbit PAb) Antibody |
|||
| BNC800386-500 | Biotium | 500uL | EUR 544 |
|
Description: Primary antibody against CD8a(Rabbit PAb), CF680 conjugate, Concentration: 0.1mg/mL |
|||
TIMP3(Rabbit PAb) Antibody |
|||
| BNC800408-100 | Biotium | 100uL | EUR 199 |
|
Description: Primary antibody against TIMP3(Rabbit PAb), CF680 conjugate, Concentration: 0.1mg/mL |
|||
TIMP3(Rabbit PAb) Antibody |
|||
| BNC800408-500 | Biotium | 500uL | EUR 544 |
|
Description: Primary antibody against TIMP3(Rabbit PAb), CF680 conjugate, Concentration: 0.1mg/mL |
|||
p40(Rabbit PAb) Antibody |
|||
| BNC810375-100 | Biotium | 100uL | EUR 199 |
|
Description: Primary antibody against p40(Rabbit PAb), CF680R conjugate, Concentration: 0.1mg/mL |
|||
p40(Rabbit PAb) Antibody |
|||
| BNC810375-500 | Biotium | 500uL | EUR 544 |
|
Description: Primary antibody against p40(Rabbit PAb), CF680R conjugate, Concentration: 0.1mg/mL |
|||
CD3e(Rabbit PAb) Antibody |
|||
| BNC810385-100 | Biotium | 100uL | EUR 199 |
|
Description: Primary antibody against CD3e(Rabbit PAb), CF680R conjugate, Concentration: 0.1mg/mL |
|||
CD3e(Rabbit PAb) Antibody |
|||
| BNC810385-500 | Biotium | 500uL | EUR 544 |
|
Description: Primary antibody against CD3e(Rabbit PAb), CF680R conjugate, Concentration: 0.1mg/mL |
|||
CD8a(Rabbit PAb) Antibody |
|||
| BNC810386-100 | Biotium | 100uL | EUR 199 |
|
Description: Primary antibody against CD8a(Rabbit PAb), CF680R conjugate, Concentration: 0.1mg/mL |
|||
CD8a(Rabbit PAb) Antibody |
|||
| BNC810386-500 | Biotium | 500uL | EUR 544 |
|
Description: Primary antibody against CD8a(Rabbit PAb), CF680R conjugate, Concentration: 0.1mg/mL |
|||
TIMP3(Rabbit PAb) Antibody |
|||
| BNC810408-100 | Biotium | 100uL | EUR 199 |
|
Description: Primary antibody against TIMP3(Rabbit PAb), CF680R conjugate, Concentration: 0.1mg/mL |
|||
TIMP3(Rabbit PAb) Antibody |
|||
| BNC810408-500 | Biotium | 500uL | EUR 544 |
|
Description: Primary antibody against TIMP3(Rabbit PAb), CF680R conjugate, Concentration: 0.1mg/mL |
|||
p40(Rabbit PAb) Antibody |
|||
| BNCP0375-250 | Biotium | 250uL | EUR 383 |
|
Description: Primary antibody against p40(Rabbit PAb), PerCP conjugate, Concentration: 0.1mg/mL |
|||
CD3e(Rabbit PAb) Antibody |
|||
| BNCP0385-250 | Biotium | 250uL | EUR 383 |
|
Description: Primary antibody against CD3e(Rabbit PAb), PerCP conjugate, Concentration: 0.1mg/mL |
|||
CD8a(Rabbit PAb) Antibody |
|||
| BNCP0386-250 | Biotium | 250uL | EUR 383 |
|
Description: Primary antibody against CD8a(Rabbit PAb), PerCP conjugate, Concentration: 0.1mg/mL |
|||
TIMP3(Rabbit PAb) Antibody |
|||
| BNCP0408-250 | Biotium | 250uL | EUR 383 |
|
Description: Primary antibody against TIMP3(Rabbit PAb), PerCP conjugate, Concentration: 0.1mg/mL |
|||
p40(Rabbit PAb) Antibody |
|||
| BNCR0375-250 | Biotium | 250uL | EUR 383 |
|
Description: Primary antibody against p40(Rabbit PAb), RPE conjugate, Concentration: 0.1mg/mL |
|||
CD3e(Rabbit PAb) Antibody |
|||
| BNCR0385-250 | Biotium | 250uL | EUR 383 |
|
Description: Primary antibody against CD3e(Rabbit PAb), RPE conjugate, Concentration: 0.1mg/mL |
|||
CD8a(Rabbit PAb) Antibody |
|||
| BNCR0386-250 | Biotium | 250uL | EUR 383 |
|
Description: Primary antibody against CD8a(Rabbit PAb), RPE conjugate, Concentration: 0.1mg/mL |
|||
TIMP3(Rabbit PAb) Antibody |
|||
| BNCR0408-250 | Biotium | 250uL | EUR 383 |
|
Description: Primary antibody against TIMP3(Rabbit PAb), RPE conjugate, Concentration: 0.1mg/mL |
|||
p40(Rabbit PAb) Antibody |
|||
| BNCA0375-250 | Biotium | 250uL | EUR 383 |
|
Description: Primary antibody against p40(Rabbit PAb), APC conjugate, Concentration: 0.1mg/mL |
|||
CD3e(Rabbit PAb) Antibody |
|||
| BNCA0385-250 | Biotium | 250uL | EUR 383 |
|
Description: Primary antibody against CD3e(Rabbit PAb), APC conjugate, Concentration: 0.1mg/mL |
|||
CD8a(Rabbit PAb) Antibody |
|||
| BNCA0386-250 | Biotium | 250uL | EUR 383 |
|
Description: Primary antibody against CD8a(Rabbit PAb), APC conjugate, Concentration: 0.1mg/mL |
|||
TIMP3(Rabbit PAb) Antibody |
|||
| BNCA0408-250 | Biotium | 250uL | EUR 383 |
|
Description: Primary antibody against TIMP3(Rabbit PAb), APC conjugate, Concentration: 0.1mg/mL |
|||
p40(Rabbit PAb) Antibody |
|||
| BNCAP0375-100 | Biotium | 100uL | EUR 199 |
|
Description: Primary antibody against p40(Rabbit PAb), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL |
|||
p40(Rabbit PAb) Antibody |
|||
| BNCAP0375-500 | Biotium | 500uL | EUR 544 |
|
Description: Primary antibody against p40(Rabbit PAb), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL |
|||
CD3e(Rabbit PAb) Antibody |
|||
| BNCAP0385-100 | Biotium | 100uL | EUR 199 |
|
Description: Primary antibody against CD3e(Rabbit PAb), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL |
|||
CD3e(Rabbit PAb) Antibody |
|||
| BNCAP0385-500 | Biotium | 500uL | EUR 544 |
|
Description: Primary antibody against CD3e(Rabbit PAb), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL |
|||
CD8a(Rabbit PAb) Antibody |
|||
| BNCAP0386-100 | Biotium | 100uL | EUR 199 |
|
Description: Primary antibody against CD8a(Rabbit PAb), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL |
|||
CD8a(Rabbit PAb) Antibody |
|||
| BNCAP0386-500 | Biotium | 500uL | EUR 544 |
|
Description: Primary antibody against CD8a(Rabbit PAb), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL |
|||
TIMP3(Rabbit PAb) Antibody |
|||
| BNCAP0408-100 | Biotium | 100uL | EUR 199 |
|
Description: Primary antibody against TIMP3(Rabbit PAb), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL |
|||
TIMP3(Rabbit PAb) Antibody |
|||
| BNCAP0408-500 | Biotium | 500uL | EUR 544 |
|
Description: Primary antibody against TIMP3(Rabbit PAb), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL |
|||
p40(Rabbit PAb) Antibody |
|||
| BNCB0375-100 | Biotium | 100uL | EUR 199 |
|
Description: Primary antibody against p40(Rabbit PAb), Biotin conjugate, Concentration: 0.1mg/mL |
|||
p40(Rabbit PAb) Antibody |
|||
| BNCB0375-500 | Biotium | 500uL | EUR 544 |
|
Description: Primary antibody against p40(Rabbit PAb), Biotin conjugate, Concentration: 0.1mg/mL |
|||
CD3e(Rabbit PAb) Antibody |
|||
| BNCB0385-100 | Biotium | 100uL | EUR 199 |
|
Description: Primary antibody against CD3e(Rabbit PAb), Biotin conjugate, Concentration: 0.1mg/mL |
|||
CD3e(Rabbit PAb) Antibody |
|||
| BNCB0385-500 | Biotium | 500uL | EUR 544 |
|
Description: Primary antibody against CD3e(Rabbit PAb), Biotin conjugate, Concentration: 0.1mg/mL |
|||
CD8a(Rabbit PAb) Antibody |
|||
| BNCB0386-100 | Biotium | 100uL | EUR 199 |
|
Description: Primary antibody against CD8a(Rabbit PAb), Biotin conjugate, Concentration: 0.1mg/mL |
|||
CD8a(Rabbit PAb) Antibody |
|||
| BNCB0386-500 | Biotium | 500uL | EUR 544 |
|
Description: Primary antibody against CD8a(Rabbit PAb), Biotin conjugate, Concentration: 0.1mg/mL |
|||
TIMP3(Rabbit PAb) Antibody |
|||
| BNCB0408-100 | Biotium | 100uL | EUR 199 |
|
Description: Primary antibody against TIMP3(Rabbit PAb), Biotin conjugate, Concentration: 0.1mg/mL |
|||
TIMP3(Rabbit PAb) Antibody |
|||
| BNCB0408-500 | Biotium | 500uL | EUR 544 |
|
Description: Primary antibody against TIMP3(Rabbit PAb), Biotin conjugate, Concentration: 0.1mg/mL |
|||
p40(Rabbit PAb) Antibody |
|||
| BNC880375-100 | Biotium | 100uL | EUR 199 |
|
Description: Primary antibody against p40(Rabbit PAb), CF488A conjugate, Concentration: 0.1mg/mL |
|||
p40(Rabbit PAb) Antibody |
|||
| BNC880375-500 | Biotium | 500uL | EUR 544 |
|
Description: Primary antibody against p40(Rabbit PAb), CF488A conjugate, Concentration: 0.1mg/mL |
|||
CD3e(Rabbit PAb) Antibody |
|||
| BNC880385-100 | Biotium | 100uL | EUR 199 |
|
Description: Primary antibody against CD3e(Rabbit PAb), CF488A conjugate, Concentration: 0.1mg/mL |
|||
CD3e(Rabbit PAb) Antibody |
|||
| BNC880385-500 | Biotium | 500uL | EUR 544 |
|
Description: Primary antibody against CD3e(Rabbit PAb), CF488A conjugate, Concentration: 0.1mg/mL |
|||
CD8a(Rabbit PAb) Antibody |
|||
| BNC880386-100 | Biotium | 100uL | EUR 199 |
|
Description: Primary antibody against CD8a(Rabbit PAb), CF488A conjugate, Concentration: 0.1mg/mL |
|||
CD8a(Rabbit PAb) Antibody |
|||
| BNC880386-500 | Biotium | 500uL | EUR 544 |
|
Description: Primary antibody against CD8a(Rabbit PAb), CF488A conjugate, Concentration: 0.1mg/mL |
|||
TIMP3(Rabbit PAb) Antibody |
|||
| BNC880408-100 | Biotium | 100uL | EUR 199 |
|
Description: Primary antibody against TIMP3(Rabbit PAb), CF488A conjugate, Concentration: 0.1mg/mL |
|||
TIMP3(Rabbit PAb) Antibody |
|||
| BNC880408-500 | Biotium | 500uL | EUR 544 |
|
Description: Primary antibody against TIMP3(Rabbit PAb), CF488A conjugate, Concentration: 0.1mg/mL |
|||
p40(Rabbit PAb) Antibody |
|||
| BNUB0375-100 | Biotium | 100uL | EUR 209 |
|
Description: Primary antibody against p40(Rabbit PAb), Concentration: 0.2mg/mL |
|||
p40(Rabbit PAb) Antibody |
|||
| BNUB0375-500 | Biotium | 500uL | EUR 458 |
|
Description: Primary antibody against p40(Rabbit PAb), Concentration: 0.2mg/mL |
|||
CD3e(Rabbit PAb) Antibody |
|||
| BNUB0385-100 | Biotium | 100uL | EUR 209 |
|
Description: Primary antibody against CD3e(Rabbit PAb), Concentration: 0.2mg/mL |
|||
CD3e(Rabbit PAb) Antibody |
|||
| BNUB0385-500 | Biotium | 500uL | EUR 458 |
|
Description: Primary antibody against CD3e(Rabbit PAb), Concentration: 0.2mg/mL |
|||
CD8a(Rabbit PAb) Antibody |
|||
| BNUB0386-100 | Biotium | 100uL | EUR 209 |
|
Description: Primary antibody against CD8a(Rabbit PAb), Concentration: 0.2mg/mL |
|||
CD8a(Rabbit PAb) Antibody |
|||
| BNUB0386-500 | Biotium | 500uL | EUR 458 |
|
Description: Primary antibody against CD8a(Rabbit PAb), Concentration: 0.2mg/mL |
|||
TIMP3(Rabbit PAb) Antibody |
|||
| BNUB0408-100 | Biotium | 100uL | EUR 209 |
|
Description: Primary antibody against TIMP3(Rabbit PAb), Concentration: 0.2mg/mL |
|||
TIMP3(Rabbit PAb) Antibody |
|||
| BNUB0408-500 | Biotium | 500uL | EUR 458 |
|
Description: Primary antibody against TIMP3(Rabbit PAb), Concentration: 0.2mg/mL |
|||
 Rabbit Anti FITC Antibody |
|||
| E61I01402 | EnoGene | 100ug | EUR 343 |
 VEGF Rabbit Polyclonal Antibody |
|||
| ES8453-100ul | ELK Biotech | 100ul | EUR 279 |
|
Description: A Rabbit Polyclonal antibody against VEGF Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC |
|||
VEGF Rabbit Polyclonal Antibody |
|||
| ES8453-50ul | ELK Biotech | 50ul | EUR 207 |
|
Description: A Rabbit Polyclonal antibody against VEGF Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC |
|||
 CD10 Rabbit Polyclonal Antibody |
|||
| ES8454-100ul | ELK Biotech | 100ul | EUR 279 |
|
Description: A Rabbit Polyclonal antibody against CD10 Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC |
|||
CD10 Rabbit Polyclonal Antibody |
|||
| ES8454-50ul | ELK Biotech | 50ul | EUR 207 |
|
Description: A Rabbit Polyclonal antibody against CD10 Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC |
|||
 NM23A Rabbit Polyclonal Antibody |
|||
| ES8455-100ul | ELK Biotech | 100ul | EUR 279 |
|
Description: A Rabbit Polyclonal antibody against NM23A Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC |
|||
NM23A Rabbit Polyclonal Antibody |
|||
| ES8455-50ul | ELK Biotech | 50ul | EUR 207 |
|
Description: A Rabbit Polyclonal antibody against NM23A Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC |
|||
 ATM Rabbit Polyclonal Antibody |
|||
| ES8456-100ul | ELK Biotech | 100ul | EUR 279 |
|
Description: A Rabbit Polyclonal antibody against ATM Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC |
|||
ATM Rabbit Polyclonal Antibody |
|||
| ES8456-50ul | ELK Biotech | 50ul | EUR 207 |
|
Description: A Rabbit Polyclonal antibody against ATM Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC |
|||
ATM Rabbit Polyclonal Antibody |
|||
| ES8457-100ul | ELK Biotech | 100ul | EUR 279 |
|
Description: A Rabbit Polyclonal antibody against ATM Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC |
|||
ATM Rabbit Polyclonal Antibody |
|||
| ES8457-50ul | ELK Biotech | 50ul | EUR 207 |
|
Description: A Rabbit Polyclonal antibody against ATM Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC |
|||
 HSC70 Rabbit Polyclonal Antibody |
|||
| ES8558-100ul | ELK Biotech | 100ul | EUR 279 |
|
Description: A Rabbit Polyclonal antibody against HSC70 Rabbit from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC |
|||
The lab-based Abbott diagnostics SARS-CoV-2 IgG assay proved to be the assay with one of the best constructive and detrimental predictive worth, and general accuracy. The POC Nal von Minden GmbH and Biozek assays additionally carried out nicely. Conclusion Our analysis demonstrates the variations in efficiency of a number of commercially out there SARS-CoV-2 antibody assays. These findings determine the restrictions of some serological exams for SARS-CoV-2. This data will assist inform take a look at choice and should have explicit relevance to suppliers working past accredited laboratories.
