Neutralizing Monoclonal Antibodies That Target the Spike Receptor Binding Domain Confer Fc Receptor-Independent Protection against SARS-CoV-2 Infection in Syrian Hamsters

| GregoryGregory | 0 Comment
Neutralizing Monoclonal Antibodies That Target the Spike Receptor Binding Domain Confer Fc Receptor-Independent Protection against SARS-CoV-2 Infection in Syrian Hamsters
The extreme acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein is the principle goal for neutralizing antibodies. These antibodies might be elicited by means of immunization or passively transferred as therapeutics within the type of convalescent-phase sera or monoclonal antibodies (MAbs). Potently neutralizing antibodies are anticipated to confer safety; nevertheless, it’s unclear whether or not weakly neutralizing antibodies contribute to safety.
Additionally, their mechanism of motion in vivo is incompletely understood. Right here, we show that 2B04, an antibody with an ultrapotent neutralizing exercise (50% inhibitory focus [IC50] of 0.04 μg/ml), protects hamsters towards SARS-CoV-2 in a prophylactic and therapeutic an infection mannequin. Safety is related to diminished weight reduction and viral hundreds in nasal turbinates and lungs after problem.
MAb 2B04 additionally blocked aerosol transmission of the virus to naive contacts. We subsequent examined three extra MAbs (2C02, 2C03, and 2E06), recognizing distinct epitopes inside the receptor binding area of spike protein that possess both minimal (2C02 and 2E06, IC50 > 20 μg/ml) or weak (2C03, IC50 of 5 μg/ml) virus neutralization capability in vitro. Solely 2C03 protected Syrian hamsters from weight reduction and diminished lung viral load after SARS-CoV-2 an infection.
Lastly, we demonstrated that Fc-Fc receptor interactions weren’t required for cover when 2B04 and 2C03 have been administered prophylactically. These findings inform the mechanism of safety and help the rational improvement of antibody-mediated safety towards SARS-CoV-2 infections. IMPORTANCE The continued coronavirus illness 2019 (COVID-19) pandemic, brought on by SARS-CoV-2, has resulted within the lack of thousands and thousands of lives. Protected and efficient vaccines are thought of the last word treatment for the worldwide social and financial disruption brought on by the pandemic.
Nevertheless, an intensive understanding of the immune correlates of safety towards this virus is missing. Right here, we characterised 4 completely different monoclonal antibodies and evaluated their capability to forestall or deal with SARS-CoV-2 an infection in Syrian hamsters. These antibodies various of their capability to neutralize the virus in vitro. Prophylactic administration of potent and weakly neutralizing antibodies protected towards SARS-CoV-2 an infection, and this impact was Fc receptor unbiased.
The potent neutralizing antibody additionally had therapeutic efficacy and eradicated onward aerosol transmission. In distinction, minimally neutralizing antibodies offered no safety towards an infection with SARS-CoV-2 in Syrian hamsters. Mixed, these research spotlight the importance of weakly neutralizing antibodies within the safety towards SARS-CoV-2 an infection and related illness.

Fast and quantitative detection of SARS-CoV-2 IgG antibody in serum utilizing optofluidic point-of-care testing fluorescence biosensor

The COVID-19 pandemic brings unprecedented disaster for public well being and economics on the earth. Detecting particular antibodies to SARS-CoV-2 is a strong complement for the analysis of COVID-19 and is essential for epidemiological research and vaccine validations. Herein, a speedy and quantitative detection methodology of anti-SARS-CoV-2 IgG antibody was constructed based mostly on the optofluidic point-of-care testing fluorescence biosensor.
With out difficult steps wanted, the moveable system is appropriate for on-site delicate dedication of anti-SARS-CoV-2 IgG antibody in serum. Beneath the optimum situations, the entire detection process is about 25 min with a detection restrict of 12.5 ng/mL that may nicely meet the diagnostic necessities. The tactic was not clearly affected by IgM and serum matrix and demonstrated to have good stability and reliability in actual pattern evaluation.
In comparison with ELISA take a look at outcomes, the proposed methodology reveals a number of benefits together with wider measurement vary and simpler operation. The tactic supplies a common platform for speedy and quantitative evaluation of different associated biomarkers, which is of significance for the prevention and management of COVID-19 pandemic.

Non-Genetic Technology of Antibody Conjugates Based mostly on Chemoenzymatic Tyrosine Click on Chemistry

The provision of instruments to generate homogeneous and secure antibody conjugates with out recombinant DNA know-how is a precious asset in fields spanning from in vitro diagnostics to in vivo imaging and therapeutics. We current right here a common method for the conjugation to human IgG1 antibodies, by using an easy two-stage protocol based mostly on antibody deglycosylation adopted by tyrosinase-mediated ortho-quinone strain-promoted click on chemistry. The know-how is validated by the environment friendly and clear era of extremely potent DAR2 and DAR4 antibody-drug conjugates (ADCs) with cytotoxic payloads MMAE or PBD dimer, and their in vitro analysis.

Section 1a/b Examine of Monoclonal Antibody CAEL-101 (11-1F4) in Sufferers with AL Amyloidosis

Systemic immunoglobulin light-chain (AL) amyloidosis is characterised by pathologic deposition of immunoglobulin gentle chains as amyloid fibrils in very important organs, resulting in organ impairment and eventual dying. That the method is reversible was evidenced in an in vivo experimental mannequin through which fibril-reactive chimeric monoclonal antibody (mAb) 11-1F4 straight focused human light-chain amyloid deposits and effected their elimination through a phagocyte-mediated response.
To find out tolerability and potential amyloidolytic impact of this agent (now designated mAb CAEL-101), we carried out a part 1a/b research involving 27 sufferers, most of whom had manifestations of organ involvement. This was an open label research through which part 1a sufferers acquired mAb CAEL-101 as a single intravenous infusion, with escalating dose ranges from 0.5 mg/m2 to 500 mg/m2 to determine the most tolerated dose (MTD). In part 1b, the antibody was administered as a graded sequence of 4 weekly infusions.
For each phases, there have been no drug-related critical antagonistic occasions or dose-limiting toxicities amongst recipients and the MTD was not reached. Majority of sufferers had deep hematologic responses however persistent organ illness previous to remedy. Fifteen of 24 sufferers (63%) who manifested cardiac, renal, hepatic, gastrointestinal, or smooth tissue involvement had a therapeutic response to mAb CAEL-101 as evidenced by serum biomarkers or goal imaging modalities with median time to response of three weeks. Infusions of mAb CAEL-101 have been well-tolerated and, for almost all, resulted in improved organ perform, notably for these with cardiac impairment.

A Comparability of the Efficiency of SARS-CoV-2 Antibody Assays in Healthcare Staff with COVID-19

Goals Since its emergence, vital curiosity surrounds the usage of SARS-CoV-2 serological exams as a substitute or as an adjunct to molecular testing. Nevertheless, given the velocity of this pandemic, paralleled with the stress to develop and supply serological exams in an expediated method, not each assay has undergone the rigorous analysis that’s normally related to medical diagnostic assays.
We aimed to look at the efficiency of a number of commercially out there SARS-CoV-2 IgG antibody assays amongst members with confirmed COVID-19 illness and detrimental controls. Strategies Serum taken between day 17 and day 40 publish onset of signs from 41 healthcare employees with RT-PCR confirmed COVID-19 illness, and pre-pandemic serum from 20 detrimental controls, have been examined for the presence of SARS-CoV-2 IgG utilizing 7 completely different assays together with point-of-care (POC) and laboratory-based assays. Outcomes Assay efficiency various.

Anti–Ki-67 Rabbit clonal antibody
MBS684317-7mLRTU 7mL(RTU)
EUR 375

Anti-PD-L1, Rabbit clonal antibody
MBS684299-004mLConcentrate 0.04mL(Concentrate)
EUR 215

Anti-PD-L1, Rabbit clonal antibody
MBS684299-01mLConcentrate 0.1mL(Concentrate)
EUR 655

Anti-PD-L1, Rabbit clonal antibody
MBS684299-02mLConcentrate 0.2mL(Concentrate)
EUR 910

Anti-PD-L1, Rabbit clonal antibody
MBS684299-1mLRTU 1mL(RTU)
EUR 205

Anti-PD-L1, Rabbit clonal antibody
MBS684299-7mLRTU 7mL(RTU)
EUR 715

Anti-c-FOS Rabbit clonal antibody
MBS684315-002mL 0.02mL
EUR 270

Anti-c-FOS Rabbit clonal antibody
MBS684315-005mL 0.05mL
EUR 475

Anti-c-FOS Rabbit clonal antibody
MBS684315-01mL 0.1mL
EUR 700

Anti-c-FOS Rabbit clonal antibody
MBS684315-5x01mL 5x0.1mL
EUR 2855

Anti–Annexin A1 Rabbit clonal antibody
MBS684313-004mLConcentrate 0.04mL(Concentrate)
EUR 215

Anti–Annexin A1 Rabbit clonal antibody
MBS684313-01mLConcentrate 0.1mL(Concentrate)
EUR 365

Anti–Annexin A1 Rabbit clonal antibody
MBS684313-02mLConcentrate 0.2mL(Concentrate)
EUR 475

Anti–Annexin A1 Rabbit clonal antibody
MBS684313-15mLRTU 15mL(RTU)
EUR 550

Anti–Annexin A1 Rabbit clonal antibody
MBS684313-7mLRTU 7mL(RTU)
EUR 385

Anti-PD-1 FITC Rabbit clonal antibody
MBS684310-01mL 0.1mL
EUR 245

Anti-PD-1 FITC Rabbit clonal antibody
MBS684310-100Tests 100Tests
EUR 905

Anti-PD-1 FITC Rabbit clonal antibody
MBS684310-5x100Tests 5x100Tests
EUR 3770

Anti-Annexin A1 FITC Rabbit clonal antibody
MBS684311-01mL 0.1mL
EUR 245

Anti-Annexin A1 FITC Rabbit clonal antibody
MBS684311-100Tests 100Tests
EUR 715

Anti-Annexin A1 FITC Rabbit clonal antibody
MBS684311-5x100Tests 5x100Tests
EUR 2915

Anti–SARS-CoV-2-Spike glycoprotein Rabbit clonal antibody
MBS684314-004mLConcentrate 0.04mL(Concentrate)
EUR 215

Anti–SARS-CoV-2-Spike glycoprotein Rabbit clonal antibody
MBS684314-01mLConcentrate 0.1mL(Concentrate)
EUR 540

Anti–SARS-CoV-2-Spike glycoprotein Rabbit clonal antibody
MBS684314-02mLConcentrate 0.2mL(Concentrate)
EUR 735

Anti–SARS-CoV-2-Spike glycoprotein Rabbit clonal antibody
MBS684314-15mLRTU 15mL(RTU)
EUR 870

Anti–SARS-CoV-2-Spike glycoprotein Rabbit clonal antibody
MBS684314-7mLRTU 7mL(RTU)
EUR 580

Actin clonal antibody (S12-I)
MBS566388-01mL 0.1mL
EUR 600

Actin clonal antibody (S12-I)
MBS566388-5x01mL 5x0.1mL
EUR 2645

Melanosome (human) clonal antibody (P14-V)
MBS566391-1mL 1mL
EUR 1315

Melanosome (human) clonal antibody (P14-V)
MBS566391-5x1mL 5x1mL
EUR 5855

Metallothionein (human) clonal antibody (N11-G)
MBS566390-01mL 0.1mL
EUR 775

Metallothionein (human) clonal antibody (N11-G)
MBS566390-5x01mL 5x0.1mL
EUR 3445

C-erbB-2 (human) clonal antibody (A24-V)
MBS566392-1mL 1mL
EUR 1270

C-erbB-2 (human) clonal antibody (A24-V)
MBS566392-5x1mL 5x1mL
EUR 5680

Nitric oxide synthase (inducible) clonal antibody (K13-A)
MBS566389-01mL 0.1mL
EUR 735

Nitric oxide synthase (inducible) clonal antibody (K13-A)
MBS566389-5x01mL 5x0.1mL
EUR 3250

Anti-Protein kinase Cγ clonal Monoclonal Antibody (A12-H)
M01890 100ul
EUR 688.8
Description: Rabbit Monoclonal Protein kinase Cγ clonal Antibody (A12-H). Validated in ELISA, IP, WB and tested in Human, Mouse, Rat.

Anti-Nitric oxide synthase (inducible) clonal Monoclonal Antibody (K13-A)
M00368-1 100ul
EUR 881
Description: Boster Bio Anti-Nitric oxide synthase (inducible) clonal Monoclonal Antibody (K13-A) (Catalog# M00368-1). Tested in ELISA, IHC-F, IHC-P, IP, WB application(s). This antibody reacts with Human, Mouse, Rat.

Immortalized Preadipocyte Clonal Cell Line PGF3-4; Type 1
T0801 1x10^6 cells / 1.0 ml
EUR 3950

Immortalized Preadipocyte Clonal Cell Line PGF2-8; Type 1
T0803 1x10^6 cells / 1.0 ml
EUR 3950

Immortalized Preadipocyte Clonal Cell Line SCF3-1; Type 2
T0806 1x10^6 cells / 1.0 ml
EUR 3950

Immortalized Preadipocyte Clonal Cell Line SCF3-8; Type 2
T0807 1x10^6 cells / 1.0 ml
EUR 3950

Immortalized Preadipocyte Clonal Cell Line PGF3-2; Type 2
T0808 1x10^6 cells / 1.0 ml
EUR 3950

Immortalized Preadipocyte Clonal Cell Line PGF2-2; Type 3
T0812 1x10^6 cells / 1.0 ml
EUR 3950

Immortalized Preadipocyte Clonal Cell Line PGF2-5; Type 3
T0813 1x10^6 cells / 1.0 ml
EUR 3950

Immortalized Preadipocyte Clonal Cell Line PGF3-3; Type 3
T0814 1x10^6 cells / 1.0 ml
EUR 3950

Immortalized Preadipocyte Clonal Cell Line PGF3-15; Type 3
T0802 1x10^6 cells / 1.0 ml
EUR 3950

Immortalized Preadipocyte Clonal Cell Line SCF3-11; Type 2
T0804 1x10^6 cells / 1.0 ml
EUR 3950

Immortalized Preadipocyte Clonal Cell Line SCF1-23; Type 2
T0805 1x10^6 cells / 1.0 ml
EUR 3950

Immortalized Preadipocyte Clonal Cell Line SCF1-12; Type 3
T0809 1x10^6 cells / 1.0 ml
EUR 3950

Immortalized Preadipocyte Clonal Cell Line SCF1-13; Type 3
T0810 1x10^6 cells / 1.0 ml
EUR 3950

Immortalized Preadipocyte Clonal Cell Line SCF1-15; Type 3
T0811 1x10^6 cells / 1.0 ml
EUR 3950

Immortalized Preadipocyte clonal cell lines PGF3-11; Type 1
T0815 1x10^6 cells / 1.0 ml
EUR 3950

HighQC™ SACK-Xs Lig-8 Clonal Adult Rat Hepatocytic Stem Cell
ABC-SC0108T 1 vial Ask for price
Description: Growing and expanding primary, differentiated adult cells in culture is difficult and laborious because many differentiated cells can only be maintained in vitro for a limited period of time. However, for controlled experiments, it may be necessary to maintain a consistent population of cells.Maintaining a population of adult stem cells (ASCs), allows one to exponentially propagate a population of cells in vitro, and induce differentiation when desired. This is possible with SACK cell strains and specified cell culture conditions.SACK ASC cell properties – Long-term propagation in xanthosine (Xs)-supplemented mediumSuppressed asymmetric cell kineticsDifferentiated progeny cell properties – Xs-free medium, confluent monolayer, serum reductionHepatocyte PropertiesAlbumin secretionAlpha-fetoprotein secretion (indicates presence of hepatoblasts)Alpha 1-antitrypsin expressionH4 hepatocyte antigen expressionInducible cytochrome P450 activity (CYP1A1, CYP1A2) Constitutive cytochrome P450 metabolism (CYP2E1)Spheroid formationBinucleationBiliary PropertiesCK7 expression (biliary epithelial cell marker)

HighQC™ SACK-Xs Lig-13 Clonal Adult Rat Cholangiocytic Stem Cell
ABC-SC0107T 1 vial Ask for price
Description: Growing and expanding primary, differentiated adult cells in culture is difficult and laborious because many differentiated cells can only be maintained in vitro for a limited period of time. However, for controlled experiments, it may be necessary to maintain a consistent population of cells.Maintaining a population of adult stem cells (ASCs), allows one to exponentially propagate a population of cells in vitro, and induce differentiation when desired. This is possible with SACK cell strains and specified cell culture conditions.SACK ASC cell properties – Long-term propagation in xanthosine (Xs)-supplemented mediumSuppressed asymmetric cell kineticsDifferentiated progeny cell properties – Xs-free medium supplemented with 10% rat serum, confluent monolayer; or serum reduction and Xs-free medium supplemented with 10% bovine serumBiliary PropertiesAlbumin expression, but no secretionAlpha-fetoprotein secretionCK7 expression (biliary epithelial cell marker) Form tubules with polarized cells (e.g., luminal microvilli)

pGreenFire 2.0 AP-1 clonal 293T reporter cell line (pGF2-AP1-rFluc-T2A-GFP-mPGK-Puro)
TR452C-P >2 x 10^6 cells
EUR 3080

pGreenFire 2.0 TCF/LEF clonal 293T reporter cell line (pGF2-TCF/LEF-rFluc-T2A-GFP-mPGK-Puro)
TR413C-P >2 x 10^6 cells
EUR 3080

AMH Rabbit Monoclonal Antibody [Clone R1B8]
E45R11142V-2 50 ul
EUR 195

AMH Rabbit Monoclonal Antibody [Clone R5C9]
E45R11143V-2 50 ul
EUR 195

AMH Rabbit Monoclonal Antibody [Clone R1E3]
E45R11144V-2 50 ul
EUR 195

AMH Rabbit Monoclonal Antibody [Clone R2G3]
E45R11145V-2 50 ul
EUR 195

AMH Rabbit Monoclonal Antibody [Clone R3B3]
E45R11146V-2 50 ul
EUR 195

AMH Rabbit Monoclonal Antibody [Clone R4F7]
E45R11147V-2 50 ul
EUR 195

AMH Rabbit Monoclonal Antibody [Clone R4G8]
E45R11148V-2 50 ul
EUR 195

AMH Rabbit Monoclonal Antibody [Clone R1A3]
E45R11152V-2 50 ul
EUR 195

AMH Rabbit Monoclonal Antibody [Clone R5D9]
E45R11154V-2 50 ul
EUR 195

AMH Rabbit Monoclonal Antibody [Clone R2H6]
E45R11156V-2 50 ul
EUR 195

AMH Rabbit Monoclonal Antibody [Clone R5B9]
E45R11157V-2 50 ul
EUR 195

gag Rabbit Monoclonal Antibody [Clone R1A3]
E45R11173V-2 50 ul
EUR 195

gag Rabbit Monoclonal Antibody [Clone R1A4]
E45R11174V-2 50 ul
EUR 195

gag Rabbit Monoclonal Antibody [Clone R1A6]
E45R11175V-2 50 ul
EUR 195

gag Rabbit Monoclonal Antibody [Clone R1B9]
E45R11176V-2 50 ul
EUR 195

gag Rabbit Monoclonal Antibody [Clone R1D5]
E45R11177V-2 50 ul
EUR 195

gag Rabbit Monoclonal Antibody [Clone R1E3]
E45R11178V-2 50 ul
EUR 195

gag Rabbit Monoclonal Antibody [Clone R1G3]
E45R11179V-2 50 ul
EUR 195

gag Rabbit Monoclonal Antibody [Clone R4E5]
E45R11180V-2 50 ul
EUR 195

gag Rabbit Monoclonal Antibody [Clone R5H8]
E45R11183V-2 50 ul
EUR 195

gag Rabbit Monoclonal Antibody [Clone R1E4]
E45R11188V-2 50 ul
EUR 195

gag Rabbit Monoclonal Antibody [Clone R2C3]
E45R11189V-2 50 ul
EUR 195

gag Rabbit Monoclonal Antibody [Clone R2C5]
E45R11190V-2 50 ul
EUR 195

gag Rabbit Monoclonal Antibody [Clone R3G9]
E45R11191V-2 50 ul
EUR 195

gag Rabbit Monoclonal Antibody [Clone R4A4]
E45R11192V-2 50 ul
EUR 195

gag Rabbit Monoclonal Antibody [Clone R4B3]
E45R11193V-2 50 ul
EUR 195

gag Rabbit Monoclonal Antibody [Clone R4B4]
E45R11194V-2 50 ul
EUR 195

gag Rabbit Monoclonal Antibody [Clone R4D4]
E45R11195V-2 50 ul
EUR 195

gag Rabbit Monoclonal Antibody [Clone R4D6]
E45R11196V-2 50 ul
EUR 195

gag Rabbit Monoclonal Antibody [Clone R4E3]
E45R11197V-2 50 ul
EUR 195

gag Rabbit Monoclonal Antibody [Clone R4F3]
E45R11198V-2 50 ul
EUR 195

AMH Rabbit Monoclonal Antibody [Clone R5C11]
E45R11153V-2 50 ul
EUR 195

MUC6 Rabbit Monoclonal Antibody [Clone R2F3]
E45R11164V-2 50 ul
EUR 195

gag Rabbit Monoclonal Antibody [Clone R1A12]
E45R11172V-2 50 ul
EUR 195

gag Rabbit Monoclonal Antibody [Clone R5B12]
E45R11181V-2 50 ul
EUR 195

gag Rabbit Monoclonal Antibody [Clone R5D12]
E45R11182V-2 50 ul
EUR 195

BCL2 Rabbit Monoclonal Antibody [Clone R9G7]
E45R11186V-2 50 ul
EUR 195

AMH Rabbit Monoclonal Antibody [Clone R2G3B5]
E45R11155V-2 50 ul
EUR 195

MUC6 Rabbit Monoclonal Antibody [Clone R4C11]
E45R11165V-2 50 ul
EUR 195

SOX11 Rabbit Monoclonal Antibody [Clone R3D12]
E45R11141V-2 50 ul
EUR 295

HSD17B13 Rabbit Monoclonal Antibody [Clone R3G2]
E45R11149V-2 50 ul
EUR 195

GS(GLUL) Rabbit Monoclonal Antibody [Clone R1A5]
E45R11158V-2 50 ul
EUR 195

Rabbit Anti-PERV Monoclonal Antibody, clone A5
CABT-NS1210 200 μg
EUR 830
Description: Rabbit

Rabbit Anti-DM4 monoclonal antibody, clone 4I4
CABT-ZB289 100 μl
EUR 790
Description: Rabbit

HSD17B13 Rabbit Monoclonal Antibody [Clone R5C10]
E45R11150V-2 50 ul
EUR 195

BNP (NPPB) Rabbit Monoclonal Antibody [Clone R1C4]
E45R11159V-2 50 ul
EUR 195

BNP (NPPB) Rabbit Monoclonal Antibody [Clone R2A6]
E45R11160V-2 50 ul
EUR 195

BNP (NPPB) Rabbit Monoclonal Antibody [Clone R3G3]
E45R11161V-2 50 ul
EUR 195

BNP (NPPB) Rabbit Monoclonal Antibody [Clone R5F5]
E45R11162V-2 50 ul
EUR 195

BNP (NPPB) Rabbit Monoclonal Antibody [Clone R5G8]
E45R11163V-2 50 ul
EUR 195

BNP (NPPB) Rabbit Monoclonal Antibody [Clone R2E1]
E45R11187V-2 50 ul
EUR 195

BNP (NPPB) Rabbit Monoclonal Antibody [Clone R2E2]
E45R11223V-2 50 ul
EUR 195

BNP (NPPB) Rabbit Monoclonal Antibody [Clone R4B1]
E45R11224V-2 50 ul
EUR 195

P40 (ΔNp63) Rabbit Monoclonal Antibody [Clone R1A1]
E45R11184V-2 50 ul
EUR 195

BNP (NPPB) Rabbit Monoclonal Antibody [Clone R5D11]
E45R11225V-2 50 ul
EUR 195

Anti-BRAF Rabbit Monoclonal Antibody, Clone#RM308
M00075-2 100uL
EUR 431
Description: Boster Bio Anti-BRAF Rabbit Monoclonal Antibody, Clone#RM308 (Catalog # M00075-2). Tested in IHC, WB applications. This antibody reacts with Human.

Anti-CD5 Rabbit Monoclonal Antibody, Clone#RM314
M02591-1 100uL
EUR 431
Description: Boster Bio Anti-CD5 Rabbit Monoclonal Antibody, Clone#RM314 (Catalog # M02591-1). Tested in IHC, WB applications. This antibody reacts with Human.

Anti-CD5 Rabbit Monoclonal Antibody, Clone#RM354
M02591-2 100uL
EUR 431
Description: Boster Bio Anti-CD5 Rabbit Monoclonal Antibody, Clone#RM354 (Catalog # M02591-2). Tested in IHC, WB applications. This antibody reacts with Human.

Anti-ALK Rabbit Monoclonal Antibody, Clone#RM361
M00301-1 100uL
EUR 431
Description: Boster Bio Anti-ALK Rabbit Monoclonal Antibody, Clone#RM361 (Catalog # M00301-1). Tested in IHC, WB applications. This antibody reacts with Human.

Anti-CD4 Rabbit Monoclonal Antibody, Clone#RM345
M00344-1 100uL
EUR 431
Description: Boster Bio Anti-CD4 Rabbit Monoclonal Antibody, Clone#RM345 (Catalog # M00344-1). Tested in IHC, WB applications. This antibody reacts with Human.

Rabbit monoclonal HSD17B13 Antibody,Clone OTIR3G2
TA592045 100 µl Ask for price

Rabbit monoclonal HSD17B13 Antibody,Clone OTIR3G2
TA592045S 30 µl Ask for price

Desmin(DES) Rabbit Monoclonal Antibody [Clone R4A8]
E45R11151V-2 50 ul
EUR 195

P40 (ΔNp63) Rabbit Monoclonal Antibody [Clone R3D12]
E45R11185V-2 50 ul
EUR 195

S Protein Rabbit Monoclonal Antibody [Clone R2C2]
E45R11211V-2 50 ul
EUR 195

S Protein Rabbit Monoclonal Antibody [Clone R2F9]
E45R11212V-2 50 ul
EUR 195

S Protein Rabbit Monoclonal Antibody [Clone R2G7]
E45R11213V-2 50 ul
EUR 195

S Protein Rabbit Monoclonal Antibody [Clone R4A8]
E45R11217V-2 50 ul
EUR 195

S Protein Rabbit Monoclonal Antibody [Clone R4E1]
E45R11219V-2 50 ul
EUR 195

S Protein Rabbit Monoclonal Antibody [Clone R4G5]
E45R11220V-2 50 ul
EUR 195

S Protein Rabbit Monoclonal Antibody [Clone R5G6]
E45R11222V-2 50 ul
EUR 195

S Protein Rabbit Monoclonal Antibody [Clone R5E2]
E45R11232V-2 50 ul
EUR 195

S Protein Rabbit Monoclonal Antibody [Clone R6A3]
E45R11234V-2 50 ul
EUR 195

S Protein Rabbit Monoclonal Antibody [Clone R6B1]
E45R11235V-2 50 ul
EUR 195

S Protein Rabbit Monoclonal Antibody [Clone R6G7]
E45R11236V-2 50 ul
EUR 195

S Protein Rabbit Monoclonal Antibody [Clone R7A8]
E45R11237V-2 50 ul
EUR 195

S Protein Rabbit Monoclonal Antibody [Clone R7B3]
E45R11238V-2 50 ul
EUR 195

Rabbit Anti-GFP monoclonal antibody, clone TZ1354
CABT-L630 100 ul
EUR 575.4
Description: Rabbit

Rabbit Anti-CCR2 monoclonal antibody, clone TO818
CABT-L754 100 ul
EUR 575.4
Description: Rabbit

Rabbit Anti-FOSB monoclonal antibody, clone TO814
CABT-L759 100 ul
EUR 575.4
Description: Rabbit

Rabbit Anti-CD36 monoclonal antibody, clone KK316
CABT-L823 100 ul
EUR 575.4
Description: Rabbit

Rabbit Anti-IDE monoclonal antibody, clone KK1050
CABT-L858 100 ul
EUR 575.4
Description: Rabbit

Rabbit Anti-JUP monoclonal antibody, clone KG1084
CABT-L871 100 ul
EUR 575.4
Description: Rabbit

Rabbit Anti-Src monoclonal antibody, clone KG1058
DCABH-2720 100 ul
EUR 575.4
Description: Rabbit

Rabbit Anti-FOS monoclonal antibody, clone KK1049
DCABH-2940 100 ul
EUR 575.4
Description: Rabbit

Rabbit Anti-CR2 monoclonal antibody, clone TD1792
DCABH-3596 100 ul
EUR 575.4
Description: Rabbit

Rabbit Anti-DCX monoclonal antibody, clone KK1060
DCABH-5105 100 ul
EUR 575.4
Description: Rabbit

Rabbit Anti-NOS1 monoclonal antibody, clone TU631
DCABH-9674 100 ul
EUR 575.4
Description: Rabbit

Anti-PLAP Rabbit Monoclonal Antibody, Clone#RM317
M01718-1 100uL
EUR 431
Description: Boster Bio Anti-PLAP Rabbit Monoclonal Antibody, Clone#RM317 (Catalog # M01718-1). Tested in IHC, WB applications. This antibody reacts with Human.

Anti-JAM1 Rabbit Monoclonal Antibody, Clone#RM275
M02068-1 100uL
EUR 431
Description: Boster Bio Anti-JAM1 Rabbit Monoclonal Antibody, Clone#RM275 (Catalog # M02068-1). Tested in IHC, WB applications. This antibody reacts with Human.

Anti-CD3E Rabbit Monoclonal Antibody, Clone#RM344
M02675-3 100uL
EUR 431
Description: Boster Bio Anti-CD3E Rabbit Monoclonal Antibody, Clone#RM344 (Catalog # M02675-3). Tested in IHC, WB applications. This antibody reacts with Human.

Anti-MSH6 Rabbit Monoclonal Antibody, Clone#RM376
M00553-1 100uL
EUR 431
Description: Boster Bio Anti-MSH6 Rabbit Monoclonal Antibody, Clone#RM376 (Catalog # M00553-1). Tested in IHC, WB applications. This antibody reacts with Human.

Anti-mTOR Rabbit Monoclonal Antibody, Clone#RM274
M00003-1 100uL
EUR 431
Description: Boster Bio Anti-mTOR Rabbit Monoclonal Antibody, Clone#RM274 (Catalog # M00003-1). Tested in IHC, WB applications. This antibody reacts with Human.

Anti-PTEN Rabbit Monoclonal Antibody, Clone#RM265
M00006-3 100uL
EUR 431
Description: Boster Bio Anti-PTEN Rabbit Monoclonal Antibody, Clone#RM265 (Catalog # M00006-3). Tested in IHC, WB applications. This antibody reacts with Human.

Anti-HER2 Rabbit Monoclonal Antibody, Clone#RM228
M00010-2 100ul
EUR 431
Description: Boster Bio Anti-HER2 Rabbit Monoclonal Antibody, Clone#RM228 (Catalog # M00010-2). Tested in IHC, WB applications. This antibody reacts with Human.

Anti-Akt1 Rabbit Monoclonal Antibody, Clone#RM252
M00024-3 100ul
EUR 431
Description: Boster Bio Anti-Akt1 Rabbit Monoclonal Antibody, Clone#RM252 (Catalog # M00024-3). Tested in IHC, WB applications. This antibody reacts with Human.

Anti-CD44 Rabbit Monoclonal Antibody, Clone#RM264
M00052-2 100uL
EUR 431
Description: Boster Bio Anti-CD44 Rabbit Monoclonal Antibody, Clone#RM264 (Catalog # M00052-2). Tested in IHC, WB applications. This antibody reacts with Human.

Anti-MSH2 Rabbit Monoclonal Antibody, Clone#RM375
M00140-1 100uL
EUR 431
Description: Boster Bio Anti-MSH2 Rabbit Monoclonal Antibody, Clone#RM375 (Catalog # M00140-1). Tested in IHC, WB applications. This antibody reacts with Human.

Anti-CD19 Rabbit Monoclonal Antibody, Clone#RM332
M00154-2 100uL
EUR 431
Description: Boster Bio Anti-CD19 Rabbit Monoclonal Antibody, Clone#RM332 (Catalog # M00154-2). Tested in IHC, WB applications. This antibody reacts with Human.

Anti-GFAP Rabbit Monoclonal Antibody, Clone#RM246
M00213-7 100ul
EUR 431
Description: Boster Bio Anti-GFAP Rabbit Monoclonal Antibody, Clone#RM246 (Catalog # M00213-7). Tested in IHC, WB applications. This antibody reacts with Human, Mouse.

Rabbit monoclonal HSD17B13 Antibody,Clone OTIR5C10
TA592047 100 µl Ask for price

Rabbit monoclonal HSD17B13 Antibody,Clone OTIR5C10
TA592047S 30 µl Ask for price

P16(CDKN2A) Rabbit Monoclonal Antibody [Clone R5G10]
E45R11140V-2 50 ul
EUR 195

S Protein Rabbit Monoclonal Antibody [Clone R2A11]
E45R11210V-2 50 ul
EUR 195

S Protein Rabbit Monoclonal Antibody [Clone R4A11]
E45R11216V-2 50 ul
EUR 195

S Protein Rabbit Monoclonal Antibody [Clone R4D11]
E45R11218V-2 50 ul
EUR 195

S Protein Rabbit Monoclonal Antibody [Clone R5F11]
E45R11233V-2 50 ul
EUR 195

Rabbit Monoclonal Antibody to EpCAM (Clone: ABM53D8)
MBS668486-0025mg 0.025mg
EUR 185

Rabbit Monoclonal Antibody to EpCAM (Clone: ABM53D8)
MBS668486-01mg 0.1mg
EUR 350
The lab-based Abbott diagnostics SARS-CoV-2 IgG assay proved to be the assay with one of the best constructive and detrimental predictive worth, and general accuracy. The POC Nal von Minden GmbH and Biozek assays additionally carried out nicely. Conclusion Our analysis demonstrates the variations in efficiency of a number of commercially out there SARS-CoV-2 antibody assays. These findings determine the restrictions of some serological exams for SARS-CoV-2. This data will assist inform take a look at choice and should have explicit relevance to suppliers working past accredited laboratories.
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