Insights into the conformation and self-association of a concentrated monoclonal antibody using isothermal chemical denaturation and nuclear magnetic resonance

Insights into the conformation and self-association of a concentrated monoclonal antibody using isothermal chemical denaturation and nuclear magnetic resonance
The aim of this investigation was to spotlight the utility of nuclear magnetic resonance (NMR) as a multi-attribute methodology for the characterization of therapeutic antibodies. On this case examine, we in contrast outcomes from isothermal chemical denaturation (ICD) and NMR with commonplace strategies to narrate conformational states of a mannequin monoclonal antibody (mAb1) with protein-protein interactions (PPI) that result in self – affiliation in concentrated options.
The rise in aggregation fee and relative viscosity for mAb1 was discovered to be each focus and pH dependent. The free vitality of unfolding (∆G⁰) from ICD and thermal evaluation in dilute options indicated that though the native state predominated between pH 4 – pH 7, it was disrupted on the CH2 and unfolded noncooperatively underneath acidic situations.
One-dimensional (1D) 1H NMR and two-dimensional (2D) 13C-1H NMR carried out, in concentrated options, confirmed that PPI between pH 4 – 7 occurred whereas mAb1 was within the native state. NMR corroborated that mAb1 maintained a dominant native state at formulation-relevant situations on the examined pH vary, had elevated world molecular tumbling dynamics at decrease pH and confirmed elevated PPI at larger pH situations.
This report aligns and compares typical characterization of an IgG1 with evaluation of construction by NMR and supplied a extra exact evaluation and deeper perception into the conformation of an IgG1 in concentrated options.

Elevated mycobacterium avium subsp. paratuberculosis (MAP) antibody titer in Japanese a number of sclerosis

To research whether or not antibody manufacturing in opposition to mycobacterium avium subsp. paratuberculosis (MAP) is said to scientific traits of a number of sclerosis (MS) and human leukocyte antigen (HLA) alleles, IgG antibody in opposition to three MAP peptides and two human peptides homologous to MAP had been measured in sera from 103 MS sufferers and 50 wholesome controls (HCs).
MS sufferers had larger IgG ranges in opposition to MAP2694295-303 (MAP2694-IgG) than HCs, whereas the opposite antibodies had been comparable. Multivariate evaluation demonstrated that larger MAP2694-IgG titers had been related to larger EDSS scores, however not with HLA alleles or dairy product consumption. Immune response in opposition to MAP could worsen MS incapacity.

Predominant mesangial IgM, C3, and λ gentle chain depositions and interstitial nephritis in a affected person with overlap syndrome and positivity for anti-mitochondrial M2 antibody: a case report

Overlap syndrome refers to a gaggle of situations which have scientific options of a couple of well-characterised rheumatic illness and meet the respective classification standards. There aren’t any typical renal histological findings in overlap syndrome. When sufferers with overlap syndrome develop renal dysfunction, varied potential causes, together with lupus nephritis (LN), renal disaster by systemic sclerosis, interstitial nephritis, and so forth, should be distinguished.
Right here, we report a 44-year-old lady with overlap syndrome involving systemic lupus erythematosus (SLE), diffuse cutaneous systemic scleroderma, and Sjogren’s syndrome, who was additionally optimistic for anti-mitochondrial M2 antibody. She developed glomerular haematuria, proteinuria, and enhance in creatinine appeared regularly.
Suspecting LN, renal biopsy was carried out. Nonetheless, within the interstitium, gentle infiltration of lymphocytes and plasma cells and really partial fibrosis had been noticed. Immunofluorescence microscopy revealed predominant mesangial immunoglobulin M, C3, and λ gentle chain staining. General, LN was not recognized primarily based on these findings.
Renal dysfunction was normalised by glucocorticoid remedy for three months. This case suggests the significance of a renal analysis primarily based on renal pathological findings, particularly in a case of overlap syndrome together with SLE.

A Japanese Affected person with Anti-PM/Scl and Centromere Antibody-Constructive Scleroderma-Amyopathic Dermatomyositis Overlap Syndrome Who Developed Renal Disaster

Anti-PM/Scl antibodies are related to the overlap syndrome of systemic sclerosis and dermatomyositis/polymyositis (SSc-DM/PM), and are present in 50% of SSc-DM/PM instances in Europe and the USA, whereas they’re uncommon in Japan. We report a case of an 80-year-old Japanese feminine with SSc-amyopathic dermatomyositis (ADM) overlap syndrome, who developed scleroderma renal disaster (SRC), a complication of SSc.
She had optimistic antinuclear antibodies in a discrete-speckled and nucleolar sample and anticentromere antibodies and anti-PM/Scl antibodies had been confirmed by ELISA and immunoprecipitation, respectively. The incidence fee of SRC in SSc sufferers varies considerably relying on the specificity of autoantibodies, with the very best incidence of ~50% in anti-RNA polymerase III antibody optimistic sufferers, adopted by ~10% in anti-PM/Scl and decrease incidence of 0.45% in anticentromere antibody-positive instances.
Anti-PM/Scl antibodies are unusual in Japanese sufferers presumably because of its robust affiliation with sure HLA haplotype that’s uncommon in Japanese. Scientific significance of anti-PM/Scl antibodies in Japanese sufferers will should be clarified with accumulation of instances in future research.

Intrinsic physicochemical profile of marketed antibody-based biotherapeutics

Feeding biopharma pipelines with biotherapeutic candidates that possess fascinating developability profiles will help enhance the productiveness of biologic drug discovery and improvement. Right here, we’ve got derived an in silico profile by analyzing computed physicochemical descriptors for the variable areas (Fv) present in 77 marketed antibody-based biotherapeutics. Fv areas of those biotherapeutics show vital diversities of their germlines, complementarity figuring out area loop lengths, hydrophobicity, and cost distributions.
Moreover, an evaluation of 24 physicochemical descriptors, calculated utilizing homology-based molecular fashions, has yielded 5 nonredundant descriptors whose distributions symbolize stability, isoelectric level, and molecular floor traits of their Fv areas. Fv areas of candidates from our inner discovery campaigns, human next-generation sequencing repertoires, and people in clinical-stages (CST) had been assessed for similarity with the physicochemical profile derived right here.
The Fv areas in 33% of CST antibodies present physicochemical properties which are dissimilar to presently marketed biotherapeutics. As compared, physicochemical traits of ∼29% of the Fv areas in human antibodies and ∼27% of our inner hits deviated considerably from these of marketed biotherapeutics.

CD146 Antibody

E80804-6 100μl
EUR 225
Description: Available in various conjugation types.

CD146, Antibody

GWB-5E0362 7 ml Ask for price

CD146 antibody

E3M00066 200ul
EUR 275
Description: Available in various conjugation types.

CD146 Antibody

49868 100ul
EUR 499

CD146 Antibody

49868-100ul 100ul
EUR 399.6

CD146 Antibody

49868-50ul 50ul
EUR 286.8

CD146 antibody

70R-14273 100 ug
EUR 386.4
Description: Affinity purified Mouse polyclonal CD146 antibody

CD146 Antibody

20-abx242914
  • Ask for price
  • Ask for price
  • 100 ul
  • 50 ul

CD146 Antibody

GWB-B30DF0 0.05 ml Ask for price

CD146 Antibody

GWB-DD3800 0.025 mg Ask for price

CD146, Antibody

GWB-8CDD04 1 ml Ask for price

CD146 Antibody

GWB-6DB1F0 0.2 mg Ask for price

CD146 Antibody

R20269-0.1ML 100ul
EUR 347.65
Description: This recombinant CD146 antibody reacts to human CD146 (Cell surface glycoprotein MUC18). It may also react to the mouse and rat protein, as predicted by immunogen homology.

CD146 Antibody

R30152 100 ug
EUR 356.15
Description: CD146 (cluster of differentiation 146), also known as MCAM and MUC18, is a cell adhesion molecule used as a marker for endothelial cell lineage. CD146 has been demonstrated to appear on a small subset of T and B lymphocytes in the peripheral blood of healthy individuals. It has been seen as a marker for mesenchymal stem cells isolated from multiple adult and fetal organs, and its expression may be linked to multipotency mesenchymal stem cells with greater differentiation potential express higher levels of CD146 on the cell surface.

CD146 Antibody

abx242914-1096tests 10 × 96 tests Ask for price

CD146 Antibody

abx242914-596tests 5 × 96 tests
EUR 400

CD146 Antibody

abx242914-96tests 96 tests
EUR 287.5

CD146 Mouse mAb

E2M50051 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

CD146 Rabbit pAb

E2380835 100ul
EUR 225
Description: Available in various conjugation types.

CD146 Rabbit mAb

E2R22825 100ul
EUR 255
Description: Available in various conjugation types.

CD146 Rabbit pAb

E2382870 100μl
EUR 225
Description: Available in various conjugation types.

CD146 Rabbit mAb

58649 100ul
EUR 339

CD146 Rabbit mAb

A24343 100μL
EUR 128.7
Description: Recombinant protein of human CYP24A1.

CD146 Rabbit mAb

E2R50151 100ul
EUR 385
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

MCAM(CD146) Antibody

48005 100ul
EUR 429

MCAM(CD146) Antibody

48005-100ul 100ul
EUR 399.6

MCAM(CD146) Antibody

48005-50ul 50ul
EUR 286.8

CD146 (MCAM) Antibody

E80806-5 100μl
EUR 225
Description: Available in various conjugation types.

CD146/MCAM antibody

E39-01428 100ug/100ul
EUR 225
Description: Available in various conjugation types.

CD146 Antibody (FITC)

abx200496-100tests 100 tests
EUR 477.6

CD146 Antibody (FITC)

GWB-DB8468 0.025 mg Ask for price

CD146 Antibody (FITC)

GWB-883F89 0.025 mg Ask for price

CD146 Antibody (FITC)

GWB-694A75 0.1 mg Ask for price

CD146 antibody (biotin)

61R-CD146aHUBT 100 tests
EUR 540
Description: Mouse monoclonal CD146 antibody (biotin)

CD146 Antibody (Biotin)

abx200500-100ug 100 ug
EUR 460.8

CD146 Recombinant Protein

E43CP0270 500ug
EUR 580

CD146 polyclonal antibody

E43P0270P 100ul
EUR 225
Description: Available in various conjugation types.

CD146 Conjugated Antibody

C49868 100ul
EUR 476.4

CD146 Antibody (PreservativeFree)

GWB-7A59D1 1 mg Ask for price

Anti-Hu CD146 PE

1P-783-T025 25 tests
EUR 121

Anti-Hu CD146 PE

1P-783-T100 100 tests
EUR 242

Anti CD146/MUC18 (c3.19.1)

E40YR1641 1 mg
EUR 2960
Description: Available in various conjugation types.

PE anti-mouse CD146

E16FMP146-025U 25 μg
EUR 520
Description: Available in various conjugation types.

PE anti-mouse CD146

E16FMP146-100U 100 μg
EUR 1126.67
Description: Available in various conjugation types.

PE anti-human CD146

E16FHP146-025 25 tests
EUR 411.67
Description: Available in various conjugation types.

PE anti-human CD146

E16FHP146-100 100 tests
EUR 975
Description: Available in various conjugation types.

CD146/MCAM Rabbit pAb

E2382825 100ul
EUR 225
Description: Available in various conjugation types.

CD146/MCAM Rabbit mAb

A22195 100μL
EUR 1557.4
Description: A synthetic peptide corresponding to a sequence within amino acids 50-150 of human Hex (Q03014).

CD146/MCAM Rabbit mAb

A9703 100μL
EUR 157.3
Description: Recombinant fusion protein containing a sequence corresponding to amino acids 23-203 of mouse CD2 (NP_038514.1).

Anti-Hu CD146 PerCP

PC-783-T100 100tests
EUR 242

CD146/MCAM Antibody (CT)

6801-100 each
EUR 379.2

APC anti-mouse CD146

E16FMA146-025U 25 μg
EUR 541.67
Description: Available in various conjugation types.

APC anti-mouse CD146

E16FMA146-100U 100 μg
EUR 1191.67
Description: Available in various conjugation types.

APC anti-human CD146

E16FHA146-025 25 tests
EUR 476.67
Description: Available in various conjugation types.

APC anti-human CD146

E16FHA146-100 100 tests
EUR 1061.67
Description: Available in various conjugation types.

CD146 mouse mAb (PT0278)

E11-124036 100ul
EUR 225
Description: Available in various conjugation types.

CD146 mouse mAb(PT0278)

E44H11912 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

FITC anti-mouse CD146

E16FMF146-025U 25 μg
EUR 455
Description: Available in various conjugation types.

FITC anti-mouse CD146

E16FMF146-100U 100 μg
EUR 910
Description: Available in various conjugation types.

FITC anti-human CD146

E16FHF146-025 25 tests
EUR 455
Description: Available in various conjugation types.

FITC anti-human CD146

E16FHF146-100 100 tests
EUR 975
Description: Available in various conjugation types.

Anti-Hu CD146 Purified

11-783-C025 0.025 mg
EUR 71.5

Anti-Hu CD146 Purified

11-783-C100 0.1 mg
EUR 143

anti- CD146/MCAM antibody

FNab01428 100µg
EUR 606.3
Description: Antibody raised against CD146/MCAM

anti- CD146/MCAM antibody

FNab01429 100µg
EUR 702
Description: Antibody raised against CD146/MCAM

CD146 Antibody / MCAM / MUC18

RQ5661 100 ug
EUR 356.15
Description: CD146 (cluster of differentiation 146), also known as the melanoma cell adhesion molecule (MCAM) or cell surface glycoprotein MUC18, is a 113kDa cell adhesion molecule currently used as a marker for endothelial cell lineage. MCAM, a member of the immunoglobulin superfamily, is homologous to several cell adhesion molecules and is associated with tumor progression and the development of metastasis in human malignant melanoma. By radiation hybrid analysis, this gene is mapped to chromosome 11q23.3. MCAM has been demonstrated to appear on a small subset of T and B lymphocytes in the peripheral blood of healthy individuals. MCAM has been seen as a marker for mesenchymal stem cells isolated from multiple adult and fetal organs, and its expression may be linked to multipotency mesenchymal stem cells with greater differentiation potential express higher levels of MCAM on the cell surface.

CD146 Antibody / MCAM / MUC18

RQ5939 100 ug
EUR 356.15
Description: CD146 (cluster of differentiation 146), also known as the melanoma cell adhesion molecule (MCAM) or cell surface glycoprotein MUC18, is a 113kDa cell adhesion molecule currently used as a marker for endothelial cell lineage. MCAM, a member of the immunoglobulin superfamily, is homologous to several cell adhesion molecules and is associated with tumor progression and the development of metastasis in human malignant melanoma. By radiation hybrid analysis, this gene is mapped to chromosome 11q23.3. MCAM has been demonstrated to appear on a small subset of T and B lymphocytes in the peripheral blood of healthy individuals. MCAM has been seen as a marker for mesenchymal stem cells isolated from multiple adult and fetal organs, and its expression may be linked to multipotency mesenchymal stem cells with greater differentiation potential express higher levels of MCAM on the cell surface.

Cd146 Antibody / MCAM / MUC18

RQ5987 100 ug
EUR 356.15
Description: In humans, the CD146 protein is encoded by the MCAM gene. It is mapped to 9; 9 A5.1. CD146 (cluster of differentiation 146) also known as the melanoma cell adhesion molecule (MCAM) or cell surface glycoprotein MUC18, is a 113kDa cell adhesion molecule currently used as a marker for endothelial cell lineage. MCAM functions as a receptor for laminin alpha 4, a matrix molecule that is broadly expressed within the vascular wall. Accordingly, MCAM is highly expressed by cells that are components of the blood vessel wall, including vascular endothelial cells, smooth muscle cells and pericytes. Its function is still poorly understood, but evidence points to it being part of the endothelial junction associated with the actin cytoskeleton. A member of the Immunoglobulin superfamily, it consists of five Ig domains, a transmembrane domain, and a cytoplasmic region. It is expressed on chicken embryonic spleen and thymus, activated human T cells, endothelial progenitors such as angioblasts and mesenchymal stem cells, and strongly expressed on blood vessel endothelium and smooth muscle.

CD146 Antibody / MCAM / MUC18

V7942-100UG 100 ug
EUR 349.3
Description: The human Mel-CAM gene maps to chromosome 11q23 and encodes a trans-membrane glycoprotein, also designated MCAM, MUC 18 or CD146, that belongs to the immunoglobulin superfamily and functions as a Ca2+-independent cell adhesion molecule. Mel-CAM expression is restricted to advanced primary and metastatic melanomas and to cell lines of the neuroectodermal lineage, but not normal melanocytes. Mel-CAM is found on 80% of advanced primary human melanomas and correlates well with development of metastatic disease.

CD146 Antibody / MCAM / MUC18

V7942-20UG 20 ug
EUR 153.3
Description: The human Mel-CAM gene maps to chromosome 11q23 and encodes a trans-membrane glycoprotein, also designated MCAM, MUC 18 or CD146, that belongs to the immunoglobulin superfamily and functions as a Ca2+-independent cell adhesion molecule. Mel-CAM expression is restricted to advanced primary and metastatic melanomas and to cell lines of the neuroectodermal lineage, but not normal melanocytes. Mel-CAM is found on 80% of advanced primary human melanomas and correlates well with development of metastatic disease.

CD146 Antibody / MCAM / MUC18

V7942SAF-100UG 100 ug
EUR 349.3
Description: The human Mel-CAM gene maps to chromosome 11q23 and encodes a trans-membrane glycoprotein, also designated MCAM, MUC 18 or CD146, that belongs to the immunoglobulin superfamily and functions as a Ca2+-independent cell adhesion molecule. Mel-CAM expression is restricted to advanced primary and metastatic melanomas and to cell lines of the neuroectodermal lineage, but not normal melanocytes. Mel-CAM is found on 80% of advanced primary human melanomas and correlates well with development of metastatic disease.

CD146 Antibody / MCAM / MUC18

V7943-100UG 100 ug
EUR 349.3
Description: The human Mel-CAM gene maps to chromosome 11q23 and encodes a trans-membrane glycoprotein, also designated MCAM, MUC 18 or CD146, that belongs to the immunoglobulin superfamily and functions as a Ca2+-independent cell adhesion molecule. Mel-CAM expression is restricted to advanced primary and metastatic melanomas and to cell lines of the neuroectodermal lineage, but not normal melanocytes. Mel-CAM is found on 80% of advanced primary human melanomas and correlates well with development of metastatic disease.

CD146 Antibody / MCAM / MUC18

V7943-20UG 20 ug
EUR 153.3
Description: The human Mel-CAM gene maps to chromosome 11q23 and encodes a trans-membrane glycoprotein, also designated MCAM, MUC 18 or CD146, that belongs to the immunoglobulin superfamily and functions as a Ca2+-independent cell adhesion molecule. Mel-CAM expression is restricted to advanced primary and metastatic melanomas and to cell lines of the neuroectodermal lineage, but not normal melanocytes. Mel-CAM is found on 80% of advanced primary human melanomas and correlates well with development of metastatic disease.

CD146 Antibody / MCAM / MUC18

V7943SAF-100UG 100 ug
EUR 349.3
Description: The human Mel-CAM gene maps to chromosome 11q23 and encodes a trans-membrane glycoprotein, also designated MCAM, MUC 18 or CD146, that belongs to the immunoglobulin superfamily and functions as a Ca2+-independent cell adhesion molecule. Mel-CAM expression is restricted to advanced primary and metastatic melanomas and to cell lines of the neuroectodermal lineage, but not normal melanocytes. Mel-CAM is found on 80% of advanced primary human melanomas and correlates well with development of metastatic disease.

CD146 Antibody / MCAM / MUC18

V8923-100UG 100ug
EUR 349.3
Description: The human MCAM gene maps to chromosome 11q23 and encodes a trans-membrane glycoprotein, also designated Mel-CAM, MUC 18 or CD146, that belongs to the immunoglobulin superfamily and functions as a Ca2+-independent cell adhesion molecule. MCAM expression is restricted to advanced primary and metastatic melanomas and to cell lines of the neuroectodermal lineage, but not normal melanocytes. MCAM is found on 80% of advanced primary human melanomas and correlates well with development of metastatic disease.

CD146 Antibody / MCAM / MUC18

V8923-20UG 20ug
EUR 153.3
Description: The human MCAM gene maps to chromosome 11q23 and encodes a trans-membrane glycoprotein, also designated Mel-CAM, MUC 18 or CD146, that belongs to the immunoglobulin superfamily and functions as a Ca2+-independent cell adhesion molecule. MCAM expression is restricted to advanced primary and metastatic melanomas and to cell lines of the neuroectodermal lineage, but not normal melanocytes. MCAM is found on 80% of advanced primary human melanomas and correlates well with development of metastatic disease.

CD146 Antibody / MCAM / MUC18

V8923SAF-100UG 100ug
EUR 349.3
Description: The human MCAM gene maps to chromosome 11q23 and encodes a trans-membrane glycoprotein, also designated Mel-CAM, MUC 18 or CD146, that belongs to the immunoglobulin superfamily and functions as a Ca2+-independent cell adhesion molecule. MCAM expression is restricted to advanced primary and metastatic melanomas and to cell lines of the neuroectodermal lineage, but not normal melanocytes. MCAM is found on 80% of advanced primary human melanomas and correlates well with development of metastatic disease.

CD146 Antibody / MCAM / MUC18

V7138-100UG 100 ug
EUR 424.15
Description: CD146/MUC18/MCAM plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration. [UniProt]

CD146 Antibody / MCAM / MUC18

V7138-20UG 20 ug
EUR 186.15
Description: CD146/MUC18/MCAM plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration. [UniProt]

CD146 Antibody / MCAM / MUC18

V7138IHC-7ML 7 ml
EUR 424.15
Description: CD146/MUC18/MCAM plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration. [UniProt]

CD146 Antibody / MCAM / MUC18

V7138SAF-100UG 100 ug
EUR 424.15
Description: CD146/MUC18/MCAM plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration. [UniProt]

CD146 Antibody / MCAM / MUC18

V2696-100UG 100 ug
EUR 424.15
Description: The human Mel-CAM gene maps to chromosome 11q23 and encodes a trans-membrane glycoprotein, also designated MCAM, MUC 18 or CD146, that belongs to the immunoglobulin superfamily and functions as a Ca2+-independent cell adhesion molecule. MCAM expression is restricted to advanced primary and metastatic melanomas and to cell lines of the neuroectodermal lineage, but not normal melanocytes. It is found on 80% of advanced primary human melanomas and correlates well with development of metastatic disease.

CD146 Antibody / MCAM / MUC18

V2696-20UG 20 ug
EUR 186.15
Description: The human Mel-CAM gene maps to chromosome 11q23 and encodes a trans-membrane glycoprotein, also designated MCAM, MUC 18 or CD146, that belongs to the immunoglobulin superfamily and functions as a Ca2+-independent cell adhesion molecule. MCAM expression is restricted to advanced primary and metastatic melanomas and to cell lines of the neuroectodermal lineage, but not normal melanocytes. It is found on 80% of advanced primary human melanomas and correlates well with development of metastatic disease.

CD146 Antibody / MCAM / MUC18

V2696IHC-7ML 7 ml
EUR 424.15
Description: The human Mel-CAM gene maps to chromosome 11q23 and encodes a trans-membrane glycoprotein, also designated MCAM, MUC 18 or CD146, that belongs to the immunoglobulin superfamily and functions as a Ca2+-independent cell adhesion molecule. MCAM expression is restricted to advanced primary and metastatic melanomas and to cell lines of the neuroectodermal lineage, but not normal melanocytes. It is found on 80% of advanced primary human melanomas and correlates well with development of metastatic disease.

CD146 Antibody / MCAM / MUC18

V2696SAF-100UG 100 ug
EUR 424.15
Description: The human Mel-CAM gene maps to chromosome 11q23 and encodes a trans-membrane glycoprotein, also designated MCAM, MUC 18 or CD146, that belongs to the immunoglobulin superfamily and functions as a Ca2+-independent cell adhesion molecule. MCAM expression is restricted to advanced primary and metastatic melanomas and to cell lines of the neuroectodermal lineage, but not normal melanocytes. It is found on 80% of advanced primary human melanomas and correlates well with development of metastatic disease.

CD146 Antibody / MCAM / MUC18

V2697-100UG 100 ug
EUR 424.15
Description: The human Mel-CAM gene maps to chromosome 11q23 and encodes a trans-membrane glycoprotein, also designated MCAM, MUC 18 or CD146, that belongs to the immunoglobulin superfamily and functions as a Ca2+-independent cell adhesion molecule. CD146 expression is restricted to advanced primary and metastatic melanomas and to cell lines of the neuroectodermal lineage, but not normal melanocytes. It is found on 80% of advanced primary human melanomas and correlates well with development of metastatic disease.

CD146 Antibody / MCAM / MUC18

V2697-20UG 20 ug
EUR 186.15
Description: The human Mel-CAM gene maps to chromosome 11q23 and encodes a trans-membrane glycoprotein, also designated MCAM, MUC 18 or CD146, that belongs to the immunoglobulin superfamily and functions as a Ca2+-independent cell adhesion molecule. CD146 expression is restricted to advanced primary and metastatic melanomas and to cell lines of the neuroectodermal lineage, but not normal melanocytes. It is found on 80% of advanced primary human melanomas and correlates well with development of metastatic disease.

CD146 Antibody / MCAM / MUC18

V2697IHC-7ML 7 ml
EUR 424.15
Description: The human Mel-CAM gene maps to chromosome 11q23 and encodes a trans-membrane glycoprotein, also designated MCAM, MUC 18 or CD146, that belongs to the immunoglobulin superfamily and functions as a Ca2+-independent cell adhesion molecule. CD146 expression is restricted to advanced primary and metastatic melanomas and to cell lines of the neuroectodermal lineage, but not normal melanocytes. It is found on 80% of advanced primary human melanomas and correlates well with development of metastatic disease.

CD146 Antibody / MCAM / MUC18

V2697SAF-100UG 100 ug
EUR 424.15
Description: The human Mel-CAM gene maps to chromosome 11q23 and encodes a trans-membrane glycoprotein, also designated MCAM, MUC 18 or CD146, that belongs to the immunoglobulin superfamily and functions as a Ca2+-independent cell adhesion molecule. CD146 expression is restricted to advanced primary and metastatic melanomas and to cell lines of the neuroectodermal lineage, but not normal melanocytes. It is found on 80% of advanced primary human melanomas and correlates well with development of metastatic disease.

CD146 Antibody / MCAM / MUC18

V2698-100UG 100 ug
EUR 424.15
Description: The human CD146 gene maps to chromosome 11q23 and encodes a trans-membrane glycoprotein, also designated MCAM, MUC 18, that belongs to the immunoglobulin superfamily and functions as a Ca2+-independent cell adhesion molecule. CD146 expression is restricted to advanced primary and metastatic melanomas and to cell lines of the neuroectodermal lineage, but not normal melanocytes. It is found on 80% of advanced primary human melanomas and correlates well with development of metastatic disease.

CD146 Antibody / MCAM / MUC18

V2698-20UG 20 ug
EUR 186.15
Description: The human CD146 gene maps to chromosome 11q23 and encodes a trans-membrane glycoprotein, also designated MCAM, MUC 18, that belongs to the immunoglobulin superfamily and functions as a Ca2+-independent cell adhesion molecule. CD146 expression is restricted to advanced primary and metastatic melanomas and to cell lines of the neuroectodermal lineage, but not normal melanocytes. It is found on 80% of advanced primary human melanomas and correlates well with development of metastatic disease.

CD146 Antibody / MCAM / MUC18

V2698IHC-7ML 7 ml
EUR 424.15
Description: The human CD146 gene maps to chromosome 11q23 and encodes a trans-membrane glycoprotein, also designated MCAM, MUC 18, that belongs to the immunoglobulin superfamily and functions as a Ca2+-independent cell adhesion molecule. CD146 expression is restricted to advanced primary and metastatic melanomas and to cell lines of the neuroectodermal lineage, but not normal melanocytes. It is found on 80% of advanced primary human melanomas and correlates well with development of metastatic disease.

CD146 Antibody / MCAM / MUC18

V2698SAF-100UG 100 ug
EUR 424.15
Description: The human CD146 gene maps to chromosome 11q23 and encodes a trans-membrane glycoprotein, also designated MCAM, MUC 18, that belongs to the immunoglobulin superfamily and functions as a Ca2+-independent cell adhesion molecule. CD146 expression is restricted to advanced primary and metastatic melanomas and to cell lines of the neuroectodermal lineage, but not normal melanocytes. It is found on 80% of advanced primary human melanomas and correlates well with development of metastatic disease.

CD146 Antibody / MCAM / MUC18

V2699-100UG 100 ug
EUR 424.15
Description: The human Mel-CAM gene maps to chromosome 11q23 and encodes a trans-membrane glycoprotein, also designated MCAM, MUC 18 or CD146, that belongs to the immunoglobulin superfamily and functions as a Ca2+-independent cell adhesion molecule. CD146 expression is restricted to advanced primary and metastatic melanomas and to cell lines of the neuroectodermal lineage, but not normal melanocytes. It is found on 80% of advanced primary human melanomas and correlates well with development of metastatic disease.

CD146 Antibody / MCAM / MUC18

V2699-20UG 20 ug
EUR 186.15
Description: The human Mel-CAM gene maps to chromosome 11q23 and encodes a trans-membrane glycoprotein, also designated MCAM, MUC 18 or CD146, that belongs to the immunoglobulin superfamily and functions as a Ca2+-independent cell adhesion molecule. CD146 expression is restricted to advanced primary and metastatic melanomas and to cell lines of the neuroectodermal lineage, but not normal melanocytes. It is found on 80% of advanced primary human melanomas and correlates well with development of metastatic disease.

CD146 Antibody / MCAM / MUC18

V2699IHC-7ML 7 ml
EUR 424.15
Description: The human Mel-CAM gene maps to chromosome 11q23 and encodes a trans-membrane glycoprotein, also designated MCAM, MUC 18 or CD146, that belongs to the immunoglobulin superfamily and functions as a Ca2+-independent cell adhesion molecule. CD146 expression is restricted to advanced primary and metastatic melanomas and to cell lines of the neuroectodermal lineage, but not normal melanocytes. It is found on 80% of advanced primary human melanomas and correlates well with development of metastatic disease.

CD146 Antibody / MCAM / MUC18

V2699SAF-100UG 100 ug
EUR 424.15
Description: The human Mel-CAM gene maps to chromosome 11q23 and encodes a trans-membrane glycoprotein, also designated MCAM, MUC 18 or CD146, that belongs to the immunoglobulin superfamily and functions as a Ca2+-independent cell adhesion molecule. CD146 expression is restricted to advanced primary and metastatic melanomas and to cell lines of the neuroectodermal lineage, but not normal melanocytes. It is found on 80% of advanced primary human melanomas and correlates well with development of metastatic disease.

CD146 Antibody / MCAM / MUC18

V2189-100UG 100 ug
EUR 424.15
Description: The human Mel-CAM gene maps to chromosome 11q23 and encodes a trans-membrane glycoprotein, also designated MCAM, MUC18 or CD146, that belongs to the immunoglobulin superfamily and functions as a Ca2+-independent cell adhesion molecule. MUC18 expression is restricted to advanced primary and metastatic melanomas and to cell lines of the neuroectodermal lineage, but not normal melanocytes. MUC18 / CD146 is found on 80% of advanced primary human melanomas and correlates well with development of metastatic disease.

CD146 Antibody / MCAM / MUC18

V2189-20UG 20 ug
EUR 186.15
Description: The human Mel-CAM gene maps to chromosome 11q23 and encodes a trans-membrane glycoprotein, also designated MCAM, MUC18 or CD146, that belongs to the immunoglobulin superfamily and functions as a Ca2+-independent cell adhesion molecule. MUC18 expression is restricted to advanced primary and metastatic melanomas and to cell lines of the neuroectodermal lineage, but not normal melanocytes. MUC18 / CD146 is found on 80% of advanced primary human melanomas and correlates well with development of metastatic disease.

CD146 Antibody / MCAM / MUC18

V2189SAF-100UG 100 ug
EUR 424.15
Description: The human Mel-CAM gene maps to chromosome 11q23 and encodes a trans-membrane glycoprotein, also designated MCAM, MUC18 or CD146, that belongs to the immunoglobulin superfamily and functions as a Ca2+-independent cell adhesion molecule. MUC18 expression is restricted to advanced primary and metastatic melanomas and to cell lines of the neuroectodermal lineage, but not normal melanocytes. MUC18 / CD146 is found on 80% of advanced primary human melanomas and correlates well with development of metastatic disease.

CD146 Antibody / MCAM / MUC18

V3638-100UG 100 ug
EUR 349.3
Description: CD146 expression is restricted to advanced primary and metastatic melanomas and to cell lines of the neuroectodermal lineage, but not normal melanocytes. It is found on 80% of advanced primary human melanomas and correlates well with development of metastatic disease.

CD146 Antibody / MCAM / MUC18

V3638-20UG 20 ug
EUR 153.3
Description: CD146 expression is restricted to advanced primary and metastatic melanomas and to cell lines of the neuroectodermal lineage, but not normal melanocytes. It is found on 80% of advanced primary human melanomas and correlates well with development of metastatic disease.

CD146 Antibody / MCAM / MUC18

V3638IHC-7ML 7 ml
EUR 349.3
Description: CD146 expression is restricted to advanced primary and metastatic melanomas and to cell lines of the neuroectodermal lineage, but not normal melanocytes. It is found on 80% of advanced primary human melanomas and correlates well with development of metastatic disease.

CD146 Antibody / MCAM / MUC18

V3638SAF-100UG 100 ug
EUR 349.3
Description: CD146 expression is restricted to advanced primary and metastatic melanomas and to cell lines of the neuroectodermal lineage, but not normal melanocytes. It is found on 80% of advanced primary human melanomas and correlates well with development of metastatic disease.

Anti-MCAM(CD146) Antibody

0806-5 100ul
EUR 189
Description: CD146 is a cell surface glycoprotein, originally identified as a melanoma antigen, whose expression is associated with tumor progression and the development of metastatic potential. Overexpression of CD146 in breast carcinoma cells results in a more cohesive cell growth and in the formation of smaller tumors in nude mice. During implantation and placentation, CD146 is expressed by the intermediate trophoblast in the placental site and binds to its putative receptor in uterine smooth muscle cells thus limiting trophoblastic invasion in the myometrium.

Purified anti-mouse CD146

E16FMU146-050U 50 μg
EUR 368.33
Description: Available in various conjugation types.

Purified anti-mouse CD146

E16FMU146-200U 200 μg
EUR 1148.33
Description: Available in various conjugation types.

Purified anti-human CD146

E16FHU146-025U 25 μg
EUR 260
Description: Available in various conjugation types.

Purified anti-human CD146

E16FHU146-100U 100 μg
EUR 455
Description: Available in various conjugation types.

CD146 Human -BIOTIN, Antibody

GWB-C3AFF3 100 TESTS Ask for price

MCAM(CD146) Conjugated Antibody

C48005 100ul
EUR 476.4

Polyclonal Anti- CD146 Antibody

GWB-BBP611 0.1 mg Ask for price

CD146/MCAM Polyclonal Antibody

E-AB-92375-120uL 120uL
EUR 320
Description: Unconjugated

CD146/MCAM Polyclonal Antibody

E-AB-92375-200uL 200uL
EUR 530
Description: Unconjugated

CD146/MCAM Polyclonal Antibody

E-AB-92375-60uL 60uL
EUR 200
Description: Unconjugated

CD146/MCAM Polyclonal Antibody

E-AB-92375-each each Ask for price
Description: Unconjugated

CD146/MCAM Polyclonal Antibody

E-AB-91654-120uL 120uL
EUR 320
Description: Unconjugated

CD146/MCAM Polyclonal Antibody

E-AB-91654-200uL 200uL
EUR 530
Description: Unconjugated

CD146/MCAM Polyclonal Antibody

E-AB-91654-60uL 60uL
EUR 200
Description: Unconjugated

CD146/MCAM Polyclonal Antibody

E-AB-91654-each each Ask for price
Description: Unconjugated

Human CD146 Monoclonal antibody

146A-100T 100 test
EUR 259.6

Human CD146 Monoclonal antibody

146F-100T 100 test
EUR 215.6

Human CD146 Monoclonal antibody

146PE-100T 100 test
EUR 259.6

Human CD146 Monoclonal antibody

146PU-01MG 0,1 mg
EUR 149.6

OASL01119-50UL - CD146 Antibody

OASL01119-50UL 50ul
EUR 269

OAGA03290-100UL - CD146 Antibody

OAGA03290-100UL 100ul
EUR 369

OAAI00040-100UG - CD146 Antibody

OAAI00040-100UG 100ug
EUR 469

CD146 Rabbit Monoclonal Antibody

E10G20939 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

CD146 Rabbit Polyclonal Antibody

E10G22762 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

CD146 Rabbit Polyclonal Antibody

E10G23116 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

CD146 Monoclonal Antibody [RMC563A]

A68401
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 µl
  • 50 ul
  • 100 ul

CD146 recombinant monoclonal antibody

A5098 100ul X 3
EUR 714
Description: A recombinant monoclonal antibody from rabbit against human CD146 for WB, IF,ELISA

PE-Cy7 anti-mouse CD146

E16FMN146-025U 25 μg
EUR 585
Description: Available in various conjugation types.

PE-Cy7 anti-mouse CD146

E16FMN146-100U 100 μg
EUR 1365
Description: Available in various conjugation types.

PE-Cy7 anti-human CD146

E16FHN146-025 25 tests
EUR 585
Description: Available in various conjugation types.

PE-Cy7 anti-human CD146

E16FHN146-100 100 tests
EUR 1365
Description: Available in various conjugation types.

human anti-human CD146 mAb

E4A09C47 50ug
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

PerCP-Cy5.5 anti-mouse CD146

E16FMS146-025U 25 μg
EUR 541.67
Description: Available in various conjugation types.

PerCP-Cy5.5 anti-mouse CD146

E16FMS146-100U 100 μg
EUR 1191.67
Description: Available in various conjugation types.

PerCP-Cy5.5 anti-human CD146

E16FHS146-025 25 tests
EUR 585
Description: Available in various conjugation types.

PerCP-Cy5.5 anti-human CD146

E16FHS146-100 100 tests
EUR 1365
Description: Available in various conjugation types.

Anti-MCAM / CD146/ MUC18 antibody

STJ73585 100 µg
EUR 430.8

Polyclonal CD146/MCAM Antibody (CT)

APR00368G 0.1ml
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human CD146/MCAM (CT). This antibody is tested and proven to work in the following applications:

Recombinant Human MCAM/CD146 Protein

RP00101 20 μg
EUR 942.5

CD146 (MCAM) rabbit polyclonal antibody

AP18112PU-N 400 µl Ask for price

Rabbit anti CD146 Polyclonal Antibody

TA354502 100 µg Ask for price

Rat MCAM / CD146 Protein, His Tag

MCM-R52H4 100ug
EUR 2749.9
Description: Rat MCAM, His Tag (MCM-R52H4) is expressed from human 293 cells (HEK293). It contains AA Val 24 - Leu 560 (Accession # Q9EPF2-1).

Human MCAM / CD146 Protein, His Tag

CD6-H5229 1mg
EUR 374.5
Description: Human MCAM, His Tag (CD6-H5229) is expressed from human 293 cells (HEK293). It contains AA Val 24 - Gly 559 (Accession # NP_006491.2).

Mouse MCAM / CD146 Protein, His Tag

MCM-M52H3 100ug
EUR 2749.9
Description: Mouse MCAM, His Tag (MCM-M52H3) is expressed from human 293 cells (HEK293). It contains AA Val 24 - Val 563 (Accession # Q8R2Y2-1).

Recombinant Cluster Of Differentiation 146 (CD146)

RPU53834-100ug 100ug
EUR 564.3

Recombinant Cluster Of Differentiation 146 (CD146)

RPU53834-1mg 1mg
EUR 2501.2

Recombinant Cluster Of Differentiation 146 (CD146)

RPU53834-50ug 50ug
EUR 453.2

Recombinant Cluster Of Differentiation 146 (CD146)

RPU42728-100ug 100ug
EUR 443.3

Recombinant Cluster Of Differentiation 146 (CD146)

RPU42728-1mg 1mg
EUR 1965.6

Recombinant Cluster Of Differentiation 146 (CD146)

RPU42728-50ug 50ug
EUR 356.4
The early availability of this data will help information hit choice, lead identification, and optimization of biotherapeutic candidates. Insights from this work can even assist help portfolio threat evaluation, in-licensing, and biopharma collaborations.

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