The aim of this investigation was to spotlight the utility of nuclear magnetic resonance (NMR) as a multi-attribute methodology for the characterization of therapeutic antibodies. On this case examine, we in contrast outcomes from isothermal chemical denaturation (ICD) and NMR with commonplace strategies to narrate conformational states of a mannequin monoclonal antibody (mAb1) with protein-protein interactions (PPI) that result in self – affiliation in concentrated options.
The rise in aggregation fee and relative viscosity for mAb1 was discovered to be each focus and pH dependent. The free vitality of unfolding (∆G⁰) from ICD and thermal evaluation in dilute options indicated that though the native state predominated between pH 4 – pH 7, it was disrupted on the CH2 and unfolded noncooperatively underneath acidic situations.
One-dimensional (1D) 1H NMR and two-dimensional (2D) 13C-1H NMR carried out, in concentrated options, confirmed that PPI between pH 4 – 7 occurred whereas mAb1 was within the native state. NMR corroborated that mAb1 maintained a dominant native state at formulation-relevant situations on the examined pH vary, had elevated world molecular tumbling dynamics at decrease pH and confirmed elevated PPI at larger pH situations.
This report aligns and compares typical characterization of an IgG1 with evaluation of construction by NMR and supplied a extra exact evaluation and deeper perception into the conformation of an IgG1 in concentrated options.
Elevated mycobacterium avium subsp. paratuberculosis (MAP) antibody titer in Japanese a number of sclerosis
To research whether or not antibody manufacturing in opposition to mycobacterium avium subsp. paratuberculosis (MAP) is said to scientific traits of a number of sclerosis (MS) and human leukocyte antigen (HLA) alleles, IgG antibody in opposition to three MAP peptides and two human peptides homologous to MAP had been measured in sera from 103 MS sufferers and 50 wholesome controls (HCs).
MS sufferers had larger IgG ranges in opposition to MAP2694295-303 (MAP2694-IgG) than HCs, whereas the opposite antibodies had been comparable. Multivariate evaluation demonstrated that larger MAP2694-IgG titers had been related to larger EDSS scores, however not with HLA alleles or dairy product consumption. Immune response in opposition to MAP could worsen MS incapacity.
Predominant mesangial IgM, C3, and λ gentle chain depositions and interstitial nephritis in a affected person with overlap syndrome and positivity for anti-mitochondrial M2 antibody: a case report
Overlap syndrome refers to a gaggle of situations which have scientific options of a couple of well-characterised rheumatic illness and meet the respective classification standards. There aren’t any typical renal histological findings in overlap syndrome. When sufferers with overlap syndrome develop renal dysfunction, varied potential causes, together with lupus nephritis (LN), renal disaster by systemic sclerosis, interstitial nephritis, and so forth, should be distinguished.
Right here, we report a 44-year-old lady with overlap syndrome involving systemic lupus erythematosus (SLE), diffuse cutaneous systemic scleroderma, and Sjogren’s syndrome, who was additionally optimistic for anti-mitochondrial M2 antibody. She developed glomerular haematuria, proteinuria, and enhance in creatinine appeared regularly.
Suspecting LN, renal biopsy was carried out. Nonetheless, within the interstitium, gentle infiltration of lymphocytes and plasma cells and really partial fibrosis had been noticed. Immunofluorescence microscopy revealed predominant mesangial immunoglobulin M, C3, and λ gentle chain staining. General, LN was not recognized primarily based on these findings.
Renal dysfunction was normalised by glucocorticoid remedy for three months. This case suggests the significance of a renal analysis primarily based on renal pathological findings, particularly in a case of overlap syndrome together with SLE.
A Japanese Affected person with Anti-PM/Scl and Centromere Antibody-Constructive Scleroderma-Amyopathic Dermatomyositis Overlap Syndrome Who Developed Renal Disaster
Anti-PM/Scl antibodies are related to the overlap syndrome of systemic sclerosis and dermatomyositis/polymyositis (SSc-DM/PM), and are present in 50% of SSc-DM/PM instances in Europe and the USA, whereas they’re uncommon in Japan. We report a case of an 80-year-old Japanese feminine with SSc-amyopathic dermatomyositis (ADM) overlap syndrome, who developed scleroderma renal disaster (SRC), a complication of SSc.
She had optimistic antinuclear antibodies in a discrete-speckled and nucleolar sample and anticentromere antibodies and anti-PM/Scl antibodies had been confirmed by ELISA and immunoprecipitation, respectively. The incidence fee of SRC in SSc sufferers varies considerably relying on the specificity of autoantibodies, with the very best incidence of ~50% in anti-RNA polymerase III antibody optimistic sufferers, adopted by ~10% in anti-PM/Scl and decrease incidence of 0.45% in anticentromere antibody-positive instances.
Anti-PM/Scl antibodies are unusual in Japanese sufferers presumably because of its robust affiliation with sure HLA haplotype that’s uncommon in Japanese. Scientific significance of anti-PM/Scl antibodies in Japanese sufferers will should be clarified with accumulation of instances in future research.
Intrinsic physicochemical profile of marketed antibody-based biotherapeutics
Feeding biopharma pipelines with biotherapeutic candidates that possess fascinating developability profiles will help enhance the productiveness of biologic drug discovery and improvement. Right here, we’ve got derived an in silico profile by analyzing computed physicochemical descriptors for the variable areas (Fv) present in 77 marketed antibody-based biotherapeutics. Fv areas of those biotherapeutics show vital diversities of their germlines, complementarity figuring out area loop lengths, hydrophobicity, and cost distributions.
Moreover, an evaluation of 24 physicochemical descriptors, calculated utilizing homology-based molecular fashions, has yielded 5 nonredundant descriptors whose distributions symbolize stability, isoelectric level, and molecular floor traits of their Fv areas. Fv areas of candidates from our inner discovery campaigns, human next-generation sequencing repertoires, and people in clinical-stages (CST) had been assessed for similarity with the physicochemical profile derived right here.
The Fv areas in 33% of CST antibodies present physicochemical properties which are dissimilar to presently marketed biotherapeutics. As compared, physicochemical traits of ∼29% of the Fv areas in human antibodies and ∼27% of our inner hits deviated considerably from these of marketed biotherapeutics.
 CD146 |
|
MBS8565817-01mLAF635 |
MyBiosource |
0.1mL(AF635) |
EUR 565 |
 CD146/MCAM |
|
MBS555948-5x005mg |
MyBiosource |
5x0.05mg |
EUR 2590 |
 MUC18/ CD146 |
|
MBS438396-002mgWithBSAAzideat02mgmL |
MyBiosource |
0.02mg(WithBSA&Azideat0.2mg/mL) |
EUR 230 |
MUC18/ CD146 |
|
MBS438396-01mgWithBSAAzideat02mgmL |
MyBiosource |
0.1mg(WithBSA&Azideat0.2mg/mL) |
EUR 405 |
MUC18/ CD146 |
|
MBS438396-01mgWithoutBSAAzideat1mgmL |
MyBiosource |
0.1mg(WithoutBSA&Azideat1mg/mL) |
EUR 405 |
MUC18/ CD146 |
|
MBS438396-5x01mgWithBSAAzideat02mgmL |
MyBiosource |
5x0.1mg(WithBSA&Azideat0.2mg/mL) |
EUR 1725 |
MUC18/ CD146 |
|
MBS438396-5x01mgWithoutBSAAzideat1mgmL |
MyBiosource |
5x0.1mg(WithoutBSA&Azideat1mg/mL) |
EUR 1725 |
 CD146 antibody |
|
70R-14273 |
Fitzgerald |
100 ug |
EUR 386.4 |
|
Description: Affinity purified Mouse polyclonal CD146 antibody |
CD146 antibody |
|
10R-6489 |
Fitzgerald |
100 ug |
EUR 260 |
|
|
|
Description: Mouse monoclonal CD146 antibody |
 CD146 Antibody |
|
49868 |
SAB |
100ul |
EUR 499 |
CD146 Antibody |
|
49868-100ul |
SAB |
100ul |
EUR 399.6 |
CD146 Antibody |
|
49868-50ul |
SAB |
50ul |
EUR 286.8 |
CD146 Antibody |
|
20-abx242914 |
Abbexa |
-
Ask for price
-
Ask for price
|
|
|
|
CD146 Antibody |
|
abx242914-1096tests |
Abbexa |
10 × 96 tests |
Ask for price |
CD146 Antibody |
|
abx242914-596tests |
Abbexa |
5 × 96 tests |
EUR 400 |
CD146 Antibody |
|
abx242914-96tests |
Abbexa |
96 tests |
EUR 287.5 |
CD146 Antibody |
|
E80804-6 |
EnoGene |
100μl |
EUR 225 |
|
Description: Available in various conjugation types. |
CD146 antibody |
|
E3M00066 |
EnoGene |
200ul |
EUR 275 |
|
Description: Available in various conjugation types. |
CD146 Antibody |
|
MBS7110755-005mL |
MyBiosource |
0.05mL |
EUR 220 |
CD146 Antibody |
|
MBS7110755-01mL |
MyBiosource |
0.1mL |
EUR 300 |
CD146 Antibody |
|
MBS7110755-5x01mL |
MyBiosource |
5x0.1mL |
EUR 1350 |
CD146 Antibody |
|
MBS8564665-01mL |
MyBiosource |
0.1mL |
EUR 305 |
CD146 Antibody |
|
MBS8564665-01mLAF405L |
MyBiosource |
0.1mL(AF405L) |
EUR 565 |
CD146 Antibody |
|
MBS8564665-01mLAF405S |
MyBiosource |
0.1mL(AF405S) |
EUR 565 |
CD146 Antibody |
|
MBS8564665-01mLAF610 |
MyBiosource |
0.1mL(AF610) |
EUR 565 |
CD146 Antibody |
|
MBS8564665-01mLAF635 |
MyBiosource |
0.1mL(AF635) |
EUR 565 |
CD146 Antibody |
|
MBS8564679-01mL |
MyBiosource |
0.1mL |
EUR 305 |
CD146 Antibody |
|
MBS8564679-01mLAF405L |
MyBiosource |
0.1mL(AF405L) |
EUR 565 |
CD146 Antibody |
|
MBS8564679-01mLAF405S |
MyBiosource |
0.1mL(AF405S) |
EUR 565 |
CD146 Antibody |
|
MBS8564679-01mLAF610 |
MyBiosource |
0.1mL(AF610) |
EUR 565 |
CD146 Antibody |
|
MBS8564679-01mLAF635 |
MyBiosource |
0.1mL(AF635) |
EUR 565 |
CD146 Antibody |
|
MBS856920-01mL |
MyBiosource |
0.1mL |
EUR 310 |
CD146 Antibody |
|
MBS9436606-005mL |
MyBiosource |
0.05mL |
EUR 325 |
CD146 Antibody |
|
MBS9436606-01mL |
MyBiosource |
0.1mL |
EUR 435 |
CD146 Antibody |
|
MBS9436606-5x01mL |
MyBiosource |
5x0.1mL |
EUR 1810 |
CD146 Antibody |
|
MBS856721-01mL |
MyBiosource |
0.1mL |
EUR 310 |
 CD146 Mouse mAb |
|
E2M50051 |
EnoGene |
100ul |
EUR 255 |
|
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody |
 CD146 Rabbit mAb |
|
58649 |
SAB |
100ul |
EUR 339 |
 CD146 Rabbit pAb |
|
A23669 |
Abclonal |
1000μL |
EUR 623.48 |
CD146 Rabbit mAb |
|
A24343 |
Abclonal |
100μL |
EUR 138.16 |
|
|
|
Description: Recombinant protein of human CYP24A1. |
CD146 Rabbit pAb |
|
A25042 |
Abclonal |
50μL |
EUR 152.33 |
CD146 Rabbit pAb |
|
E2380835 |
EnoGene |
100ul |
EUR 225 |
|
Description: Available in various conjugation types. |
CD146 Rabbit pAb |
|
E2382870 |
EnoGene |
100μl |
EUR 225 |
|
Description: Available in various conjugation types. |
CD146 Rabbit mAb |
|
E2R22825 |
EnoGene |
100ul |
EUR 255 |
|
Description: Available in various conjugation types. |
CD146 Rabbit mAb |
|
E2R50151 |
EnoGene |
100ul |
EUR 385 |
|
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody |
CD146 Rabbit pAb |
|
E47R1618 |
EnoGene |
100ul |
EUR 295 |
CD146 Rabbit mAb |
|
MBS4752492-01mL |
MyBiosource |
0.1mL |
EUR 450 |
CD146 Rabbit mAb |
|
MBS4752492-5x01mL |
MyBiosource |
5x0.1mL |
EUR 1540 |
CD146 Rabbit pAb |
|
MBS8542300-01mL |
MyBiosource |
0.1mL |
EUR 305 |
CD146 Rabbit pAb |
|
MBS8542300-01mLAF405L |
MyBiosource |
0.1mL(AF405L) |
EUR 565 |
CD146 Rabbit pAb |
|
MBS8542300-01mLAF405S |
MyBiosource |
0.1mL(AF405S) |
EUR 565 |
CD146 Rabbit pAb |
|
MBS8542300-01mLAF610 |
MyBiosource |
0.1mL(AF610) |
EUR 565 |
CD146 Rabbit pAb |
|
MBS8542300-01mLAF635 |
MyBiosource |
0.1mL(AF635) |
EUR 565 |
CD146 Rabbit mAb |
|
MBS9466794-005mL |
MyBiosource |
0.05mL |
EUR 290 |
CD146 Rabbit mAb |
|
MBS9466794-01mL |
MyBiosource |
0.1mL |
EUR 435 |
CD146 Rabbit mAb |
|
MBS9466794-5x01mL |
MyBiosource |
5x0.1mL |
EUR 1810 |
 Antibody) MCAM(CD146) Antibody |
|
48005 |
SAB |
100ul |
EUR 429 |
MCAM(CD146) Antibody |
|
48005-100ul |
SAB |
100ul |
EUR 399.6 |
MCAM(CD146) Antibody |
|
48005-50ul |
SAB |
50ul |
EUR 286.8 |
) CD146 Antibody (FITC) |
|
abx200496-100tests |
Abbexa |
100 tests |
EUR 477.6 |
|
|
 Antibody) CD146 (MCAM) Antibody |
|
E80806-5 |
EnoGene |
100μl |
EUR 225 |
|
Description: Available in various conjugation types. |
 CD146/MCAM antibody |
|
E39-01428 |
EnoGene |
100ug/100ul |
EUR 225 |
|
Description: Available in various conjugation types. |
CD146 Antibody (FITC) |
|
GWB-883F89 |
GenWay Biotech |
0.025 mg |
Ask for price |
CD146 Antibody (FITC) |
|
GWB-DB8468 |
GenWay Biotech |
0.025 mg |
Ask for price |
 Antibody) MCAM (CD146) Antibody |
|
MBS9434878-005mL |
MyBiosource |
0.05mL |
EUR 325 |
MCAM (CD146) Antibody |
|
MBS9434878-01mL |
MyBiosource |
0.1mL |
EUR 445 |
MCAM (CD146) Antibody |
|
MBS9434878-5x01mL |
MyBiosource |
5x0.1mL |
EUR 1860 |
) CD146 antibody (biotin) |
|
61R-CD146aHUBT |
Fitzgerald |
100 tests |
EUR 540 |
|
|
|
Description: Mouse monoclonal CD146 antibody (biotin) |
) CD146 Antibody (Biotin) |
|
abx200500-100ug |
Abbexa |
100 ug |
EUR 460.8 |
|
|
CD146 antibody (biotin) |
|
MBS530234-100Tests |
MyBiosource |
100Tests |
EUR 695 |
CD146 antibody (biotin) |
|
MBS530234-5x100Tests |
MyBiosource |
5x100Tests |
EUR 2985 |
 Antibody) CD146 (PT0278) Antibody |
|
N1730-100uL |
Assay Biotech |
100uL |
EUR 122.5 |
|
Description: Human CD146 (PT0278) Mouse Monoclonal Antibody |
CD146 (PT0278) Antibody |
|
N1730-50uL |
Assay Biotech |
50uL |
EUR 66.5 |
|
Description: Human CD146 (PT0278) Mouse Monoclonal Antibody |
 Recombinant Human CD146 |
|
MBS555515-0002mg |
MyBiosource |
0.002mg |
EUR 345 |
Recombinant Human CD146 |
|
MBS555515-0005mg |
MyBiosource |
0.005mg |
EUR 505 |
Recombinant Human CD146 |
|
MBS555515-5x0005mg |
MyBiosource |
5x0.005mg |
EUR 2125 |
 CD146 Conjugated Antibody |
|
C49868 |
SAB |
100ul |
EUR 476.4 |
 CD146 polyclonal antibody |
|
BZ16568 |
Bioworld Biotech |
50ul |
EUR 358 |
|
|
|
Description: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
CD146 polyclonal antibody |
|
BZ17050 |
Bioworld Biotech |
50ul |
EUR 358 |
|
|
|
Description: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
 CD146 polyclonal antibody |
|
BS90217 |
Bioworld Biotech |
50ul |
EUR 398 |
|
|
|
Description: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2 |
 CD146 Recombinant Protein |
|
E43CP0270 |
EnoGene |
500ug |
EUR 580 |
CD146 polyclonal antibody |
|
E43P0270P |
EnoGene |
100ul |
EUR 225 |
|
Description: Available in various conjugation types. |
 CD146 monoclonal antibody |
|
MB10379 |
Bioworld Biotech |
50ul |
EUR 398 |
|
|
|
Description: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
 CD146 Polyclonal Antibody |
|
MBS2555240-006mL |
MyBiosource |
0.06mL |
EUR 190 |
CD146 Polyclonal Antibody |
|
MBS2555240-012mL |
MyBiosource |
0.12mL |
EUR 265 |
CD146 Polyclonal Antibody |
|
MBS2555240-02mL |
MyBiosource |
0.2mL |
EUR 415 |
CD146 Polyclonal Antibody |
|
MBS2555240-5x02mL |
MyBiosource |
5x0.2mL |
EUR 1835 |
CD146 Polyclonal Antibody |
|
MBS2564418-002mL |
MyBiosource |
0.02mL |
EUR 130 |
CD146 Polyclonal Antibody |
|
MBS2564418-006mL |
MyBiosource |
0.06mL |
EUR 175 |
CD146 Polyclonal Antibody |
|
MBS2564418-012mL |
MyBiosource |
0.12mL |
EUR 255 |
CD146 Polyclonal Antibody |
|
MBS2564418-02mL |
MyBiosource |
0.2mL |
EUR 380 |
CD146 Polyclonal Antibody |
|
MBS2564418-5x02mL |
MyBiosource |
5x0.2mL |
EUR 1675 |
 CD146 Monoclonal Antibody |
|
MBS7112721-005mL |
MyBiosource |
0.05mL |
EUR 220 |
CD146 Monoclonal Antibody |
|
MBS7112721-01mL |
MyBiosource |
0.1mL |
EUR 300 |
CD146 Monoclonal Antibody |
|
MBS7112721-5x01mL |
MyBiosource |
5x0.1mL |
EUR 1350 |
CD146 Recombinant Protein |
|
NCP0270 |
Bioworld Biotech |
500ug |
Ask for price |
|
|
|
Description: Melanoma cell adhesion molecule (MCAM, MUC18, CD146) is an immunoglobulin superfamily member originally described as a cell surface adhesion protein and marker of the progression and metastasis of melanoma. Expression of MCAM protein is seen in vascular endothelial cells, activated T lymphocytes, smooth muscle, and bone marrow stromal cells. Research studies demonstrate increased MCAM expression in endothelial cells from angiogenesis-related disorders, including inflammatory bowel disease, Crohn’s disease, rheumatoid arthritis, tumors, and chronic renal failure. MCAM-expressing human mesenchymal stromal cells (hMSC) in the hematopoietic microenvironment are responsible for maintaining the self-renewal of hematopoietic stem and progenitor cells (HSPC) through direct contact between hMSC and HSPC. Related studies suggest that activation of the Notch signaling pathway may also, in part, play a role in HSPC maintenance. Additional research indicates that MCAM may play a role in multiple sclerosis, an autoimmune inflammatory disease that affects central nervous system neurons. Endothelial MCAM within the blood-brain barrier act as adhesion receptors that permit lymphocytes to transmigrate across the barrier and produce the inflammatory lesions that characterize the disorder. |
CD146 polyclonal antibody |
|
NCP0270P |
Bioworld Biotech |
50ul |
EUR 275 |
|
|
|
Description: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2. |
CD146 Conjugated Antibody |
|
MBS9457447-01mLAF350 |
MyBiosource |
0.1mL(AF350) |
EUR 480 |
CD146 Conjugated Antibody |
|
MBS9457447-01mLAF405 |
MyBiosource |
0.1mL(AF405) |
EUR 480 |
CD146 Conjugated Antibody |
|
MBS9457447-01mLAF488 |
MyBiosource |
0.1mL(AF488) |
EUR 480 |
CD146 Conjugated Antibody |
|
MBS9457447-01mLAF555 |
MyBiosource |
0.1mL(AF555) |
EUR 480 |
CD146 Conjugated Antibody |
|
MBS9457447-01mLBiotin |
MyBiosource |
0.1mL(Biotin) |
EUR 480 |
CD146 Polyclonal Antibody |
|
RD240373A-120uL |
Reddot Biotech |
120μL |
EUR 345 |
|
|
|
Description: CD146,also known as melanoma cell adhesion molecule (MCAM) or MUC18,originally identified as a biomarker of melanoma progression,is a transmembrane glycoprotein belonging to the immunoglobulin (Ig) superfamily . Structurally,it consists of five Ig domains,a transmembrane domain,and a cytoplasmic region. In normal adult tissue,CD146 is primarily expressed by vascular endothelium and smooth muscle. CD146 is a key cell adhesion protein in vascular endothelial cell activity and angiogenesis,and has been used as marker of circulating endothelium cells (CECs) . |
CD146 Polyclonal Antibody |
|
RD240373A-200uL |
Reddot Biotech |
200μL |
EUR 570 |
|
|
|
Description: CD146,also known as melanoma cell adhesion molecule (MCAM) or MUC18,originally identified as a biomarker of melanoma progression,is a transmembrane glycoprotein belonging to the immunoglobulin (Ig) superfamily . Structurally,it consists of five Ig domains,a transmembrane domain,and a cytoplasmic region. In normal adult tissue,CD146 is primarily expressed by vascular endothelium and smooth muscle. CD146 is a key cell adhesion protein in vascular endothelial cell activity and angiogenesis,and has been used as marker of circulating endothelium cells (CECs) . |
CD146 Polyclonal Antibody |
|
RD240373A-20uL |
Reddot Biotech |
20μL |
EUR 97.5 |
|
|
|
Description: CD146,also known as melanoma cell adhesion molecule (MCAM) or MUC18,originally identified as a biomarker of melanoma progression,is a transmembrane glycoprotein belonging to the immunoglobulin (Ig) superfamily . Structurally,it consists of five Ig domains,a transmembrane domain,and a cytoplasmic region. In normal adult tissue,CD146 is primarily expressed by vascular endothelium and smooth muscle. CD146 is a key cell adhesion protein in vascular endothelial cell activity and angiogenesis,and has been used as marker of circulating endothelium cells (CECs) . |
CD146 Polyclonal Antibody |
|
RD240373A-60uL |
Reddot Biotech |
60μL |
EUR 187.5 |
|
|
|
Description: CD146,also known as melanoma cell adhesion molecule (MCAM) or MUC18,originally identified as a biomarker of melanoma progression,is a transmembrane glycoprotein belonging to the immunoglobulin (Ig) superfamily . Structurally,it consists of five Ig domains,a transmembrane domain,and a cytoplasmic region. In normal adult tissue,CD146 is primarily expressed by vascular endothelium and smooth muscle. CD146 is a key cell adhesion protein in vascular endothelial cell activity and angiogenesis,and has been used as marker of circulating endothelium cells (CECs) . |
) CD146 Antibody (PreservativeFree) |
|
GWB-7A59D1 |
GenWay Biotech |
1 mg |
Ask for price |
 Anti-Hu CD146 PE |
|
1P-783-T025 |
ExBio |
25 tests |
EUR 121 |
Anti-Hu CD146 PE |
|
1P-783-T100 |
ExBio |
100 tests |
EUR 242 |
|
|
Anti-Hu CD146 PE |
|
MBS1801441-100Tests |
MyBiosource |
100Tests |
EUR 345 |
Anti-Hu CD146 PE |
|
MBS1801441-5x100Tests |
MyBiosource |
5x100Tests |
EUR 1300 |
) Anti CD146/MUC18 (c3.19.1) |
|
E40YR1641 |
EnoGene |
1 mg |
EUR 2960 |
|
Description: Available in various conjugation types. |
 MCAM/CD146 Mouse mAb |
|
E2220819 |
EnoGene |
100ul |
EUR 225 |
|
Description: Available in various conjugation types. |
MCAM/CD146 Mouse mAb |
|
E2220873 |
EnoGene |
100ul |
EUR 225 |
|
Description: Available in various conjugation types. |
 CD146/MCAM Rabbit pAb |
|
A13927 |
Abclonal |
100μL |
EUR 623.48 |
CD146/MCAM Rabbit pAb |
|
A16916 |
Abclonal |
1000μL |
EUR 623.48 |
CD146/MCAM Rabbit pAb |
|
A17347 |
Abclonal |
1000μL |
EUR 173.58 |
CD146/MCAM Rabbit pAb |
|
A1962 |
Abclonal |
100μL |
EUR 1246.96 |
CD146/MCAM Rabbit pAb |
|
A21488 |
Abclonal |
50μL |
EUR 623.48 |
 CD146/MCAM Rabbit mAb |
|
A9703 |
Abclonal |
100μL |
EUR 828.95 |
|
|
|
Description: Recombinant fusion protein containing a sequence corresponding to amino acids 23-203 of mouse CD2 (NP_038514.1). |
CD146/MCAM Rabbit pAb |
|
A8083 |
Abclonal |
200μL |
EUR 173.58 |
CD146/MCAM Rabbit mAb |
|
A22195 |
Abclonal |
100μL |
EUR 138.16 |
|
|
|
Description: A synthetic peptide corresponding to a sequence within amino acids 50-150 of human Hex (Q03014). |
 PE anti-mouse CD146 |
|
E16FMP146-025U |
EnoGene |
25 μg |
EUR 520 |
|
Description: Available in various conjugation types. |
PE anti-mouse CD146 |
|
E16FMP146-100U |
EnoGene |
100 μg |
EUR 1126.67 |
|
Description: Available in various conjugation types. |
CD146/MCAM Rabbit mAb |
|
E45R11791N |
EnoGene |
50 ul |
EUR 346.5 |
CD146/MCAM Rabbit pAb |
|
E45R24501N |
EnoGene |
50 ul |
EUR 297.75 |
CD146/MCAM Rabbit pAb |
|
E2382825 |
EnoGene |
100ul |
EUR 225 |
|
Description: Available in various conjugation types. |
CD146/MCAM Rabbit pAb |
|
E45R29797N |
EnoGene |
50 ul |
EUR 297.75 |
CD146/MCAM Rabbit pAb |
|
E45R20489N |
EnoGene |
50 ul |
EUR 297.75 |
CD146/MCAM Rabbit pAb |
|
E45R23655N |
EnoGene |
50 ul |
EUR 297.75 |
 PE anti-human CD146 |
|
E16FHP146-025 |
EnoGene |
25 tests |
EUR 411.67 |
|
Description: Available in various conjugation types. |
PE anti-human CD146 |
|
E16FHP146-100 |
EnoGene |
100 tests |
EUR 975 |
|
Description: Available in various conjugation types. |
 MCAM/CD146 Rabbit mAb |
|
MBS435216-002mL |
MyBiosource |
0.02mL |
EUR 270 |
MCAM/CD146 Rabbit mAb |
|
MBS435216-005mL |
MyBiosource |
0.05mL |
EUR 415 |
MCAM/CD146 Rabbit mAb |
|
MBS435216-01mL |
MyBiosource |
0.1mL |
EUR 660 |
MCAM/CD146 Rabbit mAb |
|
MBS435216-5x01mL |
MyBiosource |
5x0.1mL |
EUR 2655 |
 CD146/MUC18/Mel-CAM |
|
MBS370354-01mLConcentrate |
MyBiosource |
0.1mL(Concentrate) |
EUR 220 |
CD146/MUC18/Mel-CAM |
|
MBS370354-05mLConcentrate |
MyBiosource |
0.5mL(Concentrate) |
EUR 435 |
CD146/MUC18/Mel-CAM |
|
MBS370354-1mLConcentrate |
MyBiosource |
1mL(Concentrate) |
EUR 650 |
CD146/MUC18/Mel-CAM |
|
MBS370354-3mLRTU |
MyBiosource |
3mL(RTU) |
EUR 285 |
CD146/MUC18/Mel-CAM |
|
MBS370354-7mLRTU |
MyBiosource |
7mL(RTU) |
EUR 415 |
 Human CD146 ELISA Kit |
|
MBS3800090-10x96StripWells |
MyBiosource |
10x96-Strip-Wells |
EUR 6725 |
Human CD146 ELISA Kit |
|
MBS3800090-48StripWells |
MyBiosource |
48-Strip-Wells |
EUR 550 |
Human CD146 ELISA Kit |
|
MBS3800090-5x96StripWells |
MyBiosource |
5x96-Strip-Wells |
EUR 3420 |
Human CD146 ELISA Kit |
|
MBS3800090-96StripWells |
MyBiosource |
96-Strip-Wells |
EUR 765 |
The early availability of this data will help information hit choice, lead identification, and optimization of biotherapeutic candidates. Insights from this work can even assist help portfolio threat evaluation, in-licensing, and biopharma collaborations.
