Insights into the conformation and self-association of a concentrated monoclonal antibody using isothermal chemical denaturation and nuclear magnetic resonance

| GregoryGregory | 0 Comment
Insights into the conformation and self-association of a concentrated monoclonal antibody using isothermal chemical denaturation and nuclear magnetic resonance
The aim of this investigation was to spotlight the utility of nuclear magnetic resonance (NMR) as a multi-attribute methodology for the characterization of therapeutic antibodies. On this case examine, we in contrast outcomes from isothermal chemical denaturation (ICD) and NMR with commonplace strategies to narrate conformational states of a mannequin monoclonal antibody (mAb1) with protein-protein interactions (PPI) that result in self – affiliation in concentrated options.
The rise in aggregation fee and relative viscosity for mAb1 was discovered to be each focus and pH dependent. The free vitality of unfolding (∆G⁰) from ICD and thermal evaluation in dilute options indicated that though the native state predominated between pH 4 – pH 7, it was disrupted on the CH2 and unfolded noncooperatively underneath acidic situations.
One-dimensional (1D) 1H NMR and two-dimensional (2D) 13C-1H NMR carried out, in concentrated options, confirmed that PPI between pH 4 – 7 occurred whereas mAb1 was within the native state. NMR corroborated that mAb1 maintained a dominant native state at formulation-relevant situations on the examined pH vary, had elevated world molecular tumbling dynamics at decrease pH and confirmed elevated PPI at larger pH situations.
This report aligns and compares typical characterization of an IgG1 with evaluation of construction by NMR and supplied a extra exact evaluation and deeper perception into the conformation of an IgG1 in concentrated options.

Elevated mycobacterium avium subsp. paratuberculosis (MAP) antibody titer in Japanese a number of sclerosis

To research whether or not antibody manufacturing in opposition to mycobacterium avium subsp. paratuberculosis (MAP) is said to scientific traits of a number of sclerosis (MS) and human leukocyte antigen (HLA) alleles, IgG antibody in opposition to three MAP peptides and two human peptides homologous to MAP had been measured in sera from 103 MS sufferers and 50 wholesome controls (HCs).
MS sufferers had larger IgG ranges in opposition to MAP2694295-303 (MAP2694-IgG) than HCs, whereas the opposite antibodies had been comparable. Multivariate evaluation demonstrated that larger MAP2694-IgG titers had been related to larger EDSS scores, however not with HLA alleles or dairy product consumption. Immune response in opposition to MAP could worsen MS incapacity.

Predominant mesangial IgM, C3, and λ gentle chain depositions and interstitial nephritis in a affected person with overlap syndrome and positivity for anti-mitochondrial M2 antibody: a case report

Overlap syndrome refers to a gaggle of situations which have scientific options of a couple of well-characterised rheumatic illness and meet the respective classification standards. There aren’t any typical renal histological findings in overlap syndrome. When sufferers with overlap syndrome develop renal dysfunction, varied potential causes, together with lupus nephritis (LN), renal disaster by systemic sclerosis, interstitial nephritis, and so forth, should be distinguished.
Right here, we report a 44-year-old lady with overlap syndrome involving systemic lupus erythematosus (SLE), diffuse cutaneous systemic scleroderma, and Sjogren’s syndrome, who was additionally optimistic for anti-mitochondrial M2 antibody. She developed glomerular haematuria, proteinuria, and enhance in creatinine appeared regularly.
Suspecting LN, renal biopsy was carried out. Nonetheless, within the interstitium, gentle infiltration of lymphocytes and plasma cells and really partial fibrosis had been noticed. Immunofluorescence microscopy revealed predominant mesangial immunoglobulin M, C3, and λ gentle chain staining. General, LN was not recognized primarily based on these findings.
Renal dysfunction was normalised by glucocorticoid remedy for three months. This case suggests the significance of a renal analysis primarily based on renal pathological findings, particularly in a case of overlap syndrome together with SLE.

A Japanese Affected person with Anti-PM/Scl and Centromere Antibody-Constructive Scleroderma-Amyopathic Dermatomyositis Overlap Syndrome Who Developed Renal Disaster

Anti-PM/Scl antibodies are related to the overlap syndrome of systemic sclerosis and dermatomyositis/polymyositis (SSc-DM/PM), and are present in 50% of SSc-DM/PM instances in Europe and the USA, whereas they’re uncommon in Japan. We report a case of an 80-year-old Japanese feminine with SSc-amyopathic dermatomyositis (ADM) overlap syndrome, who developed scleroderma renal disaster (SRC), a complication of SSc.
She had optimistic antinuclear antibodies in a discrete-speckled and nucleolar sample and anticentromere antibodies and anti-PM/Scl antibodies had been confirmed by ELISA and immunoprecipitation, respectively. The incidence fee of SRC in SSc sufferers varies considerably relying on the specificity of autoantibodies, with the very best incidence of ~50% in anti-RNA polymerase III antibody optimistic sufferers, adopted by ~10% in anti-PM/Scl and decrease incidence of 0.45% in anticentromere antibody-positive instances.
Anti-PM/Scl antibodies are unusual in Japanese sufferers presumably because of its robust affiliation with sure HLA haplotype that’s uncommon in Japanese. Scientific significance of anti-PM/Scl antibodies in Japanese sufferers will should be clarified with accumulation of instances in future research.

Intrinsic physicochemical profile of marketed antibody-based biotherapeutics

Feeding biopharma pipelines with biotherapeutic candidates that possess fascinating developability profiles will help enhance the productiveness of biologic drug discovery and improvement. Right here, we’ve got derived an in silico profile by analyzing computed physicochemical descriptors for the variable areas (Fv) present in 77 marketed antibody-based biotherapeutics. Fv areas of those biotherapeutics show vital diversities of their germlines, complementarity figuring out area loop lengths, hydrophobicity, and cost distributions.
Moreover, an evaluation of 24 physicochemical descriptors, calculated utilizing homology-based molecular fashions, has yielded 5 nonredundant descriptors whose distributions symbolize stability, isoelectric level, and molecular floor traits of their Fv areas. Fv areas of candidates from our inner discovery campaigns, human next-generation sequencing repertoires, and people in clinical-stages (CST) had been assessed for similarity with the physicochemical profile derived right here.
The Fv areas in 33% of CST antibodies present physicochemical properties which are dissimilar to presently marketed biotherapeutics. As compared, physicochemical traits of ∼29% of the Fv areas in human antibodies and ∼27% of our inner hits deviated considerably from these of marketed biotherapeutics.

CD146
MBS8565817-01mLAF635 0.1mL(AF635)
EUR 565

CD146
PR27039 5 ug
EUR 202.5

CD146
PR27039-B each
EUR 315

CD146/MCAM
MBS555948-005mg 0.05mg
EUR 610

CD146/MCAM
MBS555948-5x005mg 5x0.05mg
EUR 2590

CD146/MCAM
MO30005 50 ug
EUR 391.5

MUC18/ CD146
MBS438396-002mgWithBSAAzideat02mgmL 0.02mg(WithBSA&Azideat0.2mg/mL)
EUR 230

MUC18/ CD146
MBS438396-01mgWithBSAAzideat02mgmL 0.1mg(WithBSA&Azideat0.2mg/mL)
EUR 405

MUC18/ CD146
MBS438396-01mgWithoutBSAAzideat1mgmL 0.1mg(WithoutBSA&Azideat1mg/mL)
EUR 405

MUC18/ CD146
MBS438396-5x01mgWithBSAAzideat02mgmL 5x0.1mg(WithBSA&Azideat0.2mg/mL)
EUR 1725

MUC18/ CD146
MBS438396-5x01mgWithoutBSAAzideat1mgmL 5x0.1mg(WithoutBSA&Azideat1mg/mL)
EUR 1725

CD146 antibody
70R-14273 100 ug
EUR 386.4
Description: Affinity purified Mouse polyclonal CD146 antibody

CD146 antibody
10R-6489 100 ug
EUR 260
Description: Mouse monoclonal CD146 antibody

CD146 Antibody
49868 100ul
EUR 499

CD146 Antibody
49868-100ul 100ul
EUR 399.6

CD146 Antibody
49868-50ul 50ul
EUR 286.8

CD146 Antibody
20-abx242914
  • Ask for price
  • Ask for price
  • 50 ul
  • 100 ul

CD146 Antibody
abx242914-1096tests 10 × 96 tests Ask for price

CD146 Antibody
abx242914-596tests 5 × 96 tests
EUR 400

CD146 Antibody
abx242914-96tests 96 tests
EUR 287.5

CD146, Antibody
GWB-5E0362 7 ml Ask for price

CD146 Antibody
E80804-6 100μl
EUR 225
Description: Available in various conjugation types.

CD146 Antibody
GWB-B30DF0 0.05 ml Ask for price

CD146 Antibody
GWB-6DB1F0 0.2 mg Ask for price

CD146 antibody
E3M00066 200ul
EUR 275
Description: Available in various conjugation types.

CD146, Antibody
GWB-8CDD04 1 ml Ask for price

CD146 Antibody
GWB-DD3800 0.025 mg Ask for price

CD146 Antibody
MBS7110755-005mL 0.05mL
EUR 220

CD146 Antibody
MBS7110755-01mL 0.1mL
EUR 300

CD146 Antibody
MBS7110755-5x01mL 5x0.1mL
EUR 1350

CD146 Antibody
MBS8564665-01mL 0.1mL
EUR 305

CD146 Antibody
MBS8564665-01mLAF405L 0.1mL(AF405L)
EUR 565

CD146 Antibody
MBS8564665-01mLAF405S 0.1mL(AF405S)
EUR 565

CD146 Antibody
MBS8564665-01mLAF610 0.1mL(AF610)
EUR 565

CD146 Antibody
MBS8564665-01mLAF635 0.1mL(AF635)
EUR 565

CD146 Antibody
MBS8564679-01mL 0.1mL
EUR 305

CD146 Antibody
MBS8564679-01mLAF405L 0.1mL(AF405L)
EUR 565

CD146 Antibody
MBS8564679-01mLAF405S 0.1mL(AF405S)
EUR 565

CD146 Antibody
MBS8564679-01mLAF610 0.1mL(AF610)
EUR 565

CD146 Antibody
MBS8564679-01mLAF635 0.1mL(AF635)
EUR 565

CD146 Antibody
MBS856920-01mL 0.1mL
EUR 310

CD146 Antibody
MBS9436606-005mL 0.05mL
EUR 325

CD146 Antibody
MBS9436606-01mL 0.1mL
EUR 435

CD146 Antibody
MBS9436606-5x01mL 5x0.1mL
EUR 1810

CD146 Antibody
MBS856721-01mL 0.1mL
EUR 310

CD146 Mouse mAb
E2M50051 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

CD146 Rabbit mAb
58649 100ul
EUR 339

CD146 Rabbit pAb
A23669 1000μL
EUR 623.48

CD146 Rabbit mAb
A24343 100μL
EUR 138.16
Description: Recombinant protein of human CYP24A1.

CD146 Rabbit pAb
A25042 50μL
EUR 152.33

CD146 Rabbit pAb
E2380835 100ul
EUR 225
Description: Available in various conjugation types.

CD146 Rabbit pAb
E2382870 100μl
EUR 225
Description: Available in various conjugation types.

CD146 Rabbit mAb
E2R22825 100ul
EUR 255
Description: Available in various conjugation types.

CD146 Rabbit mAb
E2R50151 100ul
EUR 385
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

CD146 Rabbit pAb
E47R1618 100ul
EUR 295

CD146 Rabbit mAb
MBS4752492-01mL 0.1mL
EUR 450

CD146 Rabbit mAb
MBS4752492-5x01mL 5x0.1mL
EUR 1540

CD146 Rabbit pAb
MBS8542300-01mL 0.1mL
EUR 305

CD146 Rabbit pAb
MBS8542300-01mLAF405L 0.1mL(AF405L)
EUR 565

CD146 Rabbit pAb
MBS8542300-01mLAF405S 0.1mL(AF405S)
EUR 565

CD146 Rabbit pAb
MBS8542300-01mLAF610 0.1mL(AF610)
EUR 565

CD146 Rabbit pAb
MBS8542300-01mLAF635 0.1mL(AF635)
EUR 565

CD146 Rabbit mAb
MBS9466794-005mL 0.05mL
EUR 290

CD146 Rabbit mAb
MBS9466794-01mL 0.1mL
EUR 435

CD146 Rabbit mAb
MBS9466794-5x01mL 5x0.1mL
EUR 1810

MCAM(CD146) Antibody
48005 100ul
EUR 429

MCAM(CD146) Antibody
48005-100ul 100ul
EUR 399.6

MCAM(CD146) Antibody
48005-50ul 50ul
EUR 286.8

CD146 Antibody (FITC)
abx200496-100tests 100 tests
EUR 477.6

CD146 (MCAM) Antibody
E80806-5 100μl
EUR 225
Description: Available in various conjugation types.

CD146 Antibody (FITC)
GWB-694A75 0.1 mg Ask for price

CD146/MCAM antibody
E39-01428 100ug/100ul
EUR 225
Description: Available in various conjugation types.

CD146 Antibody (FITC)
GWB-883F89 0.025 mg Ask for price

CD146 Antibody (FITC)
GWB-DB8468 0.025 mg Ask for price

MCAM (CD146) Antibody
MBS9434878-005mL 0.05mL
EUR 325

MCAM (CD146) Antibody
MBS9434878-01mL 0.1mL
EUR 445

MCAM (CD146) Antibody
MBS9434878-5x01mL 5x0.1mL
EUR 1860

CD146 antibody (biotin)
61R-CD146aHUBT 100 tests
EUR 540
Description: Mouse monoclonal CD146 antibody (biotin)

CD146 Antibody (Biotin)
abx200500-100ug 100 ug
EUR 460.8

CD146 antibody (biotin)
MBS530234-100Tests 100Tests
EUR 695

CD146 antibody (biotin)
MBS530234-5x100Tests 5x100Tests
EUR 2985

CD146 (PT0278) Antibody
N1730-100uL 100uL
EUR 122.5
Description: Human CD146 (PT0278) Mouse Monoclonal Antibody

CD146 (PT0278) Antibody
N1730-50uL 50uL
EUR 66.5
Description: Human CD146 (PT0278) Mouse Monoclonal Antibody

Recombinant Human CD146
MBS555515-0002mg 0.002mg
EUR 345

Recombinant Human CD146
MBS555515-0005mg 0.005mg
EUR 505

Recombinant Human CD146
MBS555515-5x0005mg 5x0.005mg
EUR 2125

CD146 Conjugated Antibody
C49868 100ul
EUR 476.4

CD146 polyclonal antibody
BZ16568 50ul
EUR 358
Description: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

CD146 polyclonal antibody
BZ17050 50ul
EUR 358
Description: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

CD146 polyclonal antibody
BS90217 50ul
EUR 398
Description: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

CD146 Recombinant Protein
E43CP0270 500ug
EUR 580

CD146 polyclonal antibody
E43P0270P 100ul
EUR 225
Description: Available in various conjugation types.

CD146 monoclonal antibody
MB10379 50ul
EUR 398
Description: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

CD146 Polyclonal Antibody
MBS2555240-006mL 0.06mL
EUR 190

CD146 Polyclonal Antibody
MBS2555240-012mL 0.12mL
EUR 265

CD146 Polyclonal Antibody
MBS2555240-02mL 0.2mL
EUR 415

CD146 Polyclonal Antibody
MBS2555240-5x02mL 5x0.2mL
EUR 1835

CD146 Polyclonal Antibody
MBS2564418-002mL 0.02mL
EUR 130

CD146 Polyclonal Antibody
MBS2564418-006mL 0.06mL
EUR 175

CD146 Polyclonal Antibody
MBS2564418-012mL 0.12mL
EUR 255

CD146 Polyclonal Antibody
MBS2564418-02mL 0.2mL
EUR 380

CD146 Polyclonal Antibody
MBS2564418-5x02mL 5x0.2mL
EUR 1675

CD146 Monoclonal Antibody
MBS7112721-005mL 0.05mL
EUR 220

CD146 Monoclonal Antibody
MBS7112721-01mL 0.1mL
EUR 300

CD146 Monoclonal Antibody
MBS7112721-5x01mL 5x0.1mL
EUR 1350

CD146 Recombinant Protein
NCP0270 500ug Ask for price
Description: Melanoma cell adhesion molecule (MCAM, MUC18, CD146) is an immunoglobulin superfamily member originally described as a cell surface adhesion protein and marker of the progression and metastasis of melanoma. Expression of MCAM protein is seen in vascular endothelial cells, activated T lymphocytes, smooth muscle, and bone marrow stromal cells. Research studies demonstrate increased MCAM expression in endothelial cells from angiogenesis-related disorders, including inflammatory bowel disease, Crohn’s disease, rheumatoid arthritis, tumors, and chronic renal failure. MCAM-expressing human mesenchymal stromal cells (hMSC) in the hematopoietic microenvironment are responsible for maintaining the self-renewal of hematopoietic stem and progenitor cells (HSPC) through direct contact between hMSC and HSPC. Related studies suggest that activation of the Notch signaling pathway may also, in part, play a role in HSPC maintenance. Additional research indicates that MCAM may play a role in multiple sclerosis, an autoimmune inflammatory disease that affects central nervous system neurons. Endothelial MCAM within the blood-brain barrier act as adhesion receptors that permit lymphocytes to transmigrate across the barrier and produce the inflammatory lesions that characterize the disorder.

CD146 polyclonal antibody
NCP0270P 50ul
EUR 275
Description: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.

CD146 Conjugated Antibody
MBS9457447-01mLAF350 0.1mL(AF350)
EUR 480

CD146 Conjugated Antibody
MBS9457447-01mLAF405 0.1mL(AF405)
EUR 480

CD146 Conjugated Antibody
MBS9457447-01mLAF488 0.1mL(AF488)
EUR 480

CD146 Conjugated Antibody
MBS9457447-01mLAF555 0.1mL(AF555)
EUR 480

CD146 Conjugated Antibody
MBS9457447-01mLBiotin 0.1mL(Biotin)
EUR 480

CD146 Polyclonal Antibody
RD240373A-120uL 120μL
EUR 345
Description: CD146,also known as melanoma cell adhesion molecule (MCAM) or MUC18,originally identified as a biomarker of melanoma progression,is a transmembrane glycoprotein belonging to the immunoglobulin (Ig) superfamily . Structurally,it consists of five Ig domains,a transmembrane domain,and a cytoplasmic region. In normal adult tissue,CD146 is primarily expressed by vascular endothelium and smooth muscle. CD146 is a key cell adhesion protein in vascular endothelial cell activity and angiogenesis,and has been used as marker of circulating endothelium cells (CECs) .

CD146 Polyclonal Antibody
RD240373A-200uL 200μL
EUR 570
Description: CD146,also known as melanoma cell adhesion molecule (MCAM) or MUC18,originally identified as a biomarker of melanoma progression,is a transmembrane glycoprotein belonging to the immunoglobulin (Ig) superfamily . Structurally,it consists of five Ig domains,a transmembrane domain,and a cytoplasmic region. In normal adult tissue,CD146 is primarily expressed by vascular endothelium and smooth muscle. CD146 is a key cell adhesion protein in vascular endothelial cell activity and angiogenesis,and has been used as marker of circulating endothelium cells (CECs) .

CD146 Polyclonal Antibody
RD240373A-20uL 20μL
EUR 97.5
Description: CD146,also known as melanoma cell adhesion molecule (MCAM) or MUC18,originally identified as a biomarker of melanoma progression,is a transmembrane glycoprotein belonging to the immunoglobulin (Ig) superfamily . Structurally,it consists of five Ig domains,a transmembrane domain,and a cytoplasmic region. In normal adult tissue,CD146 is primarily expressed by vascular endothelium and smooth muscle. CD146 is a key cell adhesion protein in vascular endothelial cell activity and angiogenesis,and has been used as marker of circulating endothelium cells (CECs) .

CD146 Polyclonal Antibody
RD240373A-60uL 60μL
EUR 187.5
Description: CD146,also known as melanoma cell adhesion molecule (MCAM) or MUC18,originally identified as a biomarker of melanoma progression,is a transmembrane glycoprotein belonging to the immunoglobulin (Ig) superfamily . Structurally,it consists of five Ig domains,a transmembrane domain,and a cytoplasmic region. In normal adult tissue,CD146 is primarily expressed by vascular endothelium and smooth muscle. CD146 is a key cell adhesion protein in vascular endothelial cell activity and angiogenesis,and has been used as marker of circulating endothelium cells (CECs) .

CD146 Antibody (PreservativeFree)
GWB-7A59D1 1 mg Ask for price

Anti-Hu CD146 PE
1P-783-T025 25 tests
EUR 121

Anti-Hu CD146 PE
1P-783-T100 100 tests
EUR 242

Anti-Hu CD146 PE
MBS1801441-100Tests 100Tests
EUR 345

Anti-Hu CD146 PE
MBS1801441-5x100Tests 5x100Tests
EUR 1300

Anti CD146/MUC18 (c3.19.1)
E40YR1641 1 mg
EUR 2960
Description: Available in various conjugation types.

MCAM/CD146 Mouse mAb
E2220819 100ul
EUR 225
Description: Available in various conjugation types.

MCAM/CD146 Mouse mAb
E2220873 100ul
EUR 225
Description: Available in various conjugation types.

CD146/MCAM Rabbit pAb
A13927 100μL
EUR 623.48

CD146/MCAM Rabbit pAb
A16916 1000μL
EUR 623.48

CD146/MCAM Rabbit pAb
A17347 1000μL
EUR 173.58

CD146/MCAM Rabbit pAb
A1962 100μL
EUR 1246.96

CD146/MCAM Rabbit pAb
A21488 50μL
EUR 623.48

CD146/MCAM Rabbit mAb
A9703 100μL
EUR 828.95
Description: Recombinant fusion protein containing a sequence corresponding to amino acids 23-203 of mouse CD2 (NP_038514.1).

CD146/MCAM Rabbit pAb
A8083 200μL
EUR 173.58

CD146/MCAM Rabbit mAb
A22195 100μL
EUR 138.16
Description: A synthetic peptide corresponding to a sequence within amino acids 50-150 of human Hex (Q03014).

PE anti-mouse CD146
E16FMP146-025U 25 μg
EUR 520
Description: Available in various conjugation types.

PE anti-mouse CD146
E16FMP146-100U 100 μg
EUR 1126.67
Description: Available in various conjugation types.

CD146/MCAM Rabbit mAb
E45R11791N 50 ul
EUR 346.5

CD146/MCAM Rabbit pAb
E45R24501N 50 ul
EUR 297.75

CD146/MCAM Rabbit pAb
E2382825 100ul
EUR 225
Description: Available in various conjugation types.

CD146/MCAM Rabbit pAb
E45R29797N 50 ul
EUR 297.75

CD146/MCAM Rabbit pAb
E45R20489N 50 ul
EUR 297.75

CD146/MCAM Rabbit pAb
E45R23655N 50 ul
EUR 297.75

PE anti-human CD146
E16FHP146-025 25 tests
EUR 411.67
Description: Available in various conjugation types.

PE anti-human CD146
E16FHP146-100 100 tests
EUR 975
Description: Available in various conjugation types.

MCAM/CD146 Rabbit mAb
MBS435216-002mL 0.02mL
EUR 270

MCAM/CD146 Rabbit mAb
MBS435216-005mL 0.05mL
EUR 415

MCAM/CD146 Rabbit mAb
MBS435216-01mL 0.1mL
EUR 660

MCAM/CD146 Rabbit mAb
MBS435216-5x01mL 5x0.1mL
EUR 2655

CD146/MUC18/Mel-CAM
MBS370354-01mLConcentrate 0.1mL(Concentrate)
EUR 220

CD146/MUC18/Mel-CAM
MBS370354-05mLConcentrate 0.5mL(Concentrate)
EUR 435

CD146/MUC18/Mel-CAM
MBS370354-1mLConcentrate 1mL(Concentrate)
EUR 650

CD146/MUC18/Mel-CAM
MBS370354-3mLRTU 3mL(RTU)
EUR 285

CD146/MUC18/Mel-CAM
MBS370354-7mLRTU 7mL(RTU)
EUR 415

Human CD146 ELISA Kit
MBS3800090-10x96StripWells 10x96-Strip-Wells
EUR 6725

Human CD146 ELISA Kit
MBS3800090-48StripWells 48-Strip-Wells
EUR 550

Human CD146 ELISA Kit
MBS3800090-5x96StripWells 5x96-Strip-Wells
EUR 3420

Human CD146 ELISA Kit
MBS3800090-96StripWells 96-Strip-Wells
EUR 765
The early availability of this data will help information hit choice, lead identification, and optimization of biotherapeutic candidates. Insights from this work can even assist help portfolio threat evaluation, in-licensing, and biopharma collaborations.
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