Design, synthesis, and evaluation of HIV-1 entry inhibitors based on broadly neutralizing antibody 447-52D and gp120 V3loop interactions

Design, synthesis, and evaluation of HIV-1 entry inhibitors based on broadly neutralizing antibody 447-52D and gp120 V3loop interactions
The third variable loop area (V3 loop) on gp120 performs an necessary position in mobile entry of HIV-1. Its interplay with the mobile CD4 and coreceptors is a crucial hallmark in facilitating the bridging by gp41 and subsequent fusion of membranes for switch of viral genetic materials. Additional, the virus phenotype determines the cell tropism by way of respective co- receptor binding.
Thus, coreceptor binding motif of envelope is taken into account to be a potent anti-viral drug goal for viral entry inhibition. Nonetheless, its excessive variability in sequence is the foremost hurdle for creating inhibitors concentrating on the area. On this examine, we have now used an in silico Digital Screening and “Fragment-based” methodology to design small molecules primarily based on the gp120 V3 loop interactions with a potent broadly neutralizing human monoclonal antibody, 447-52D.
From the in silico evaluation a potent scaffold, 1,3,5-triazine was recognized for additional growth. Derivatives of 1,3,5-triazine with particular useful teams have been designed and synthesized conserving the interplay with co-receptor intact. Lastly, preliminary analysis of molecules for HIV-1 inhibition on two completely different virus strains (clade C, clade B) yielded IC50 < 5.zero μM.
The method used to design molecules primarily based on broadly neutralizing antibody, was helpful for growth of goal particular potent antiviral brokers to forestall HIV entry. The examine reported promising inhibitors that might be additional developed and studied.

Cytokine antibody array-based evaluation of IL-37 therapy results in bronchial asthma

Bronchial asthma is pushed by group 2 innate lymphoid cells, antigen-specific CD4+ T helper sort 2 cells and their cytokines corresponding to interleukin (IL)-4, IL-5, IL-13. IL-37 is decreased in bronchial asthma and negatively associated to Th2 cytokines and different pro-inflammatory cytokines. Our examine confirmed that IL-37 degree in asthmatic peripheral blood mononuclear cells was decrease than in wholesome.
Additional, IL-37 was negatively correlated with exhaled nitric oxide, bronchial asthma management take a look at rating, atopy and rhinitis historical past in asthmatics. Then an OVA-induced bronchial asthma mice mannequin handled with rhIL-37 was established.
An antibody array was employed to uncover altered cytokines induced by IL-37 in mice lung tissue. 20 proteins differentially expressed after rhIL-37 therapy and 5 of them have been validated in asthmatic peripheral blood mononuclear cells. According to cytokine antibody array, CCL3, CCL4, CCL5 decreased after IL-37 administration. Whereas CXCL9 and CXCL13 have been no change. We concluded that IL-37 scale back asthmatic signs by inhibit pro-inflammatory cytokine corresponding to CCL3, CCL4, CCL5.

Editorial: The First Monoclonal Antibody Vaccine to Forestall Malaria Heralds a New Period of Malaria Vaccines to the Plasmodium falciparum Circumsporozoite Protein (PfCSP)

Malaria impacts greater than Three billion individuals in 95 nations, with an estimated mortality charge of 400,000 per 12 months. The feminine Anopheles spp mosquito mostly transmits malaria, and the primary burden of illness is because of Plasmodium falciparum. Essentially the most ample antigen on the sporozoite floor is the Plasmodium falciparum circumsporozoite protein (PfCSP).
PfCSP is required for parasite growth and attachment to host hepatocytes. The primary potential protein vaccine, RTS,S/ASO1, consists of a recombinant fusion antigen primarily based on PfCSP. Preliminary findings from a part Three trial of RTS,S/ASO1 have been promising however resulted in suggestions for additional analysis in large-scale trials. R21, a circumsporozoite protein-based vaccine, mixed with an adjuvant, Matrix-M (MM), was lately evaluated in a part 2 investigational examine in kids between 5-17 months of age in Burkina Faso.
The R21/MM candidate vaccine resulted in excessive titers of malaria-specific antibodies. On August 26, 2021, the findings from a part 1 trial on a brand new monoclonal antibody to PfCSP, CIS43LS, confirmed {that a} single dose of the CIS43LS monoclonal antibody resulted in safety towards malaria.
These new findings have implications for the seasonal management of malaria in endemic areas and a potential future position in public well being methods to get rid of malaria. This Editorial goals to supply the background to creating and evaluating the brand new malaria vaccines that focus on PfCSP, together with the primary monoclonal antibody vaccine to malaria.

Characterization and modulation of anti-αβTCR antibodies and their respective binding websites on the βTCR chain to complement engineered T cells

T cell engineering methods provide cures to sufferers and have entered scientific observe with chimeric antibody-based receptors; αβT cell receptor (αβTCR)-based methods are, nonetheless, lagging behind. To permit a extra speedy and profitable translation to profitable ideas additionally utilizing αβTCRs for engineering, incorporating a technique for the purification of genetically modified T cells, in addition to engineered T cell deletion after switch into sufferers, might be useful.
This might enable elevated efficacy, lowered potential unwanted side effects, and improved security of newly to-be-tested lead constructions. By characterizing the antigen-binding interface of a great manufacturing course of (GMP)-grade anti-αβTCR antibody, normally used for depletion of αβT cells from stem cell transplantation merchandise, we developed a method that permits for the purification of untouched αβTCR-engineered immune cells by altering 2 amino acids solely within the TCRβ chain fixed area of launched TCR chains.
Alternatively, we engineered an antibody that targets an prolonged mutated interface of 9 amino acids within the TCRβ chain fixed area and gives the chance to additional develop depletion methods of engineered immune cells.Design, synthesis, and evaluation of HIV-1 entry inhibitors based on broadly neutralizing antibody 447-52D and gp120 V3loop interactions

Monoclonal Antibodies From Anti-NMDA Receptor Encephalitis Affected person as a Software to Research Autoimmune Seizures

Anti-N-methyl-D-aspartate (NMDA) receptor encephalitis manifests with precipitous cognitive decline, irregular actions, and extreme seizures that may be difficult to manage with typical anti-seizure drugs. We beforehand demonstrated that intracerebroventricular (i.c.v.) administration of cerebrospinal fluid from affected sufferers, or purified NMDA receptor antibodies from encephalitis sufferers to mice precipitated seizures, thereby confirming that antibodies are straight pathogenic for seizures.
Though completely different repertoires of anti-NMDA receptor antibodies might contribute to the distinct scientific manifestations in encephalitis sufferers, the position of particular antibodies within the expression of seizure, motor, and cognitive phenotypes stays unclear. Utilizing three completely different patient-derived monoclonal antibodies with distinct epitopes throughout the N-terminal area (NTD) of the NMDA receptor, we characterised the seizure burden, motor exercise and anxiety-related conduct in mice.
We discovered that steady administration of 5F5, 2G6 or 3C11 antibodies for two weeks precipitated seizures, as measured with steady EEG utilizing cortical screw electrodes. The seizure burden was comparable in all three antibody-treated teams. The seizures have been accompanied by elevated hippocampal C-C chemokine ligand 2 (CCL2) mRNA expression Three days after antibody infusion had stopped.

Anti-PD-L1

DB-241-RTU-15 15 ml
EUR 678
Description: rabbit monospecific clonal antibodies for ihc-p application; prediluted (ready to use)

Anti-PD-L1

DB-241-RTU-7 7 ml
EUR 433
Description: rabbit monospecific clonal antibodies for ihc-p application; prediluted (ready to use)

Anti-PD-L1

DB241-RTU-15 15 ml
EUR 678
Description: rabbit monospecific clonal antibodies for ihc-p application; prediluted (ready to use)

Anti-PD-L1

DB241-RTU-7 7 ml
EUR 433
Description: rabbit monospecific clonal antibodies for ihc-p application; prediluted (ready to use)

Anti-PD-L1 Antibody

A1454-100
EUR 338

Anti-PD-L1 Antibody

A1454-30T
EUR 146

Anti-PD-L1 antibody

STJ130022 50 µl
EUR 321
Description: Programmed death-ligand 1 (PD-L1) is a 40kDa type 1 transmembrane protein that suppresses immune system. PD-L1 is expressed in hematopoietic and nonhematopoietic cells including T cells and B cells and various types of tumor cells. PD-L1 binds to its receptor Programmed death 1 (PD1). During infection or inflammation, PD1PD-L1 interaction is important for preventing autoimmunity. In tumor microenvironments, PD1-PD-L1 interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human cancers. In recent years, PDL1 has become an important biomarker and immunotherapy target for many types of malignancies.

Anti-PD-L1 antibody

STJ130023 50 µl
EUR 321
Description: Programmed death-ligand 1 (PD-L1) is a 40kDa type 1 transmembrane protein that suppresses immune system. PD-L1 is expressed in hematopoietic and nonhematopoietic cells including T cells and B cells and various types of tumor cells. PD-L1 binds to its receptor Programmed death 1 (PD1). During infection or inflammation, PD1PD-L1 interaction is important for preventing autoimmunity. In tumor microenvironments, PD1-PD-L1 interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human cancers. In recent years, PDL1 has become an important biomarker and immunotherapy target for many types of malignancies.

Anti-PD-L1 antibody

STJ130024 50 µl
EUR 321
Description: Programmed death-ligand 1 (PD-L1) is a 40kDa type 1 transmembrane protein that suppresses immune system. PD-L1 is expressed in hematopoietic and nonhematopoietic cells including T cells and B cells and various types of tumor cells. PD-L1 binds to its receptor Programmed death 1 (PD1). During infection or inflammation, PD1PD-L1 interaction is important for preventing autoimmunity. In tumor microenvironments, PD1-PD-L1 interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human cancers. In recent years, PDL1 has become an important biomarker and immunotherapy target for many types of malignancies.

Anti-PD-L1 antibody

STJ180217 0.1 ml
EUR 280

Anti-PD-L1 antibody

STJ180383 0.1 ml
EUR 246

Anti-PD-L1 antibody

STJ190082 200 µl
EUR 197
Description: Unconjugated Mouse monoclonal to PD-L1 (AS1A7)

anti- PD-L1/CD274 antibody

FNab06280 100µg
EUR 505.25
  • Recommended dilution: WB: 1:200-1:1000
  • IP: 1:500-1:2000
  • IHC: 1:20-1:200
  • IF: 1:10-1:100
  • Immunogen: CD274 molecule
  • Uniprot ID: Q9NZQ7
  • Research Area: Cancer, Immunology, Signal Transduction
Description: Antibody raised against PD-L1/CD274

anti- PD-L1/CD274 antibody

FNab06281 100µg
EUR 548.75
  • Recommended dilution: WB: 1:500-1:5000
  • IHC: 1:100-1:500
  • IF: 1:50-1:500
  • Immunogen: CD274 molecule
  • Uniprot ID: Q9NZQ7
  • Research Area: Cancer, Immunology, Signal Transduction
Description: Antibody raised against PD-L1/CD274

Anti-PD-L1 Antibody (IHC411)

A1549-50
EUR 185

Anti-PD-L1/CD274 Antibody

PB9994 100ug/vial
EUR 294

Anti-PD-L1/CD274 Antibody

PB9154 100ug/vial
EUR 294

Anti-PD-L1/CD274 antibody

PAab06280 100 ug
EUR 355

Anti-PD-L1/CD274 Antibody

PA1851 100ug/vial
EUR 294

Anti-CD274 / PD-L1 antibody

STJ70646 100 µg
EUR 359

PD-L1, CD274

E6TA00108 0.1mg
EUR 343

PD-L1 Protein

20-abx261703
  • EUR 3418.00
  • EUR 328.00
  • EUR 230.00
  • 1 mg
  • 20 ug
  • 5 ug
  • Shipped within 5-10 working days.

PD-L1 Protein

20-abx263458
  • EUR 1609.00
  • EUR 328.00
  • EUR 230.00
  • 100 ug
  • 10 ug
  • 2 µg
  • Shipped within 5-10 working days.

PD-L1 Antibody

49251-100ul 100ul
EUR 333

PD-L1 Antibody

49251-50ul 50ul
EUR 239

PD-L1 Antibody

P1013-01m 0.1m
EUR 187

PD-L1 Antibody

P1013-1ml 1ml
EUR 673

Anti-PD-L1 (Atezolizumab), humanized Antibody

A1305-100
EUR 501

Anti-CD274 / PD-L1, Biotinylated antibody

STJ73200 100 µg
EUR 359

PD-1/PD-L1 inhibitor 2

B6023-25 25 mg
EUR 438
Description: PD-1/PD-L1 inhibitor 2 is a PD-1/PD-L1 interaction inhibitor.

PD-1/PD-L1 inhibitor 2

B6023-5 5 mg
EUR 171
Description: PD-1/PD-L1 inhibitor 2 is a PD-1/PD-L1 interaction inhibitor.

PD-1/PD-L1 inhibitor 1

B6172-25 25 mg
EUR 453
Description: IC50: 0.006-0.10 ?MPD-1/PD-L1 inhibitor 1 is a PD-1/PD-L1 interaction inhibitor.Plenty of studies show that blocking the PD-1/PD-Ll interactions can lead to the restorage and augment of T cell activation in many systems.

PD-1/PD-L1 inhibitor 1

B6172-5 5 mg
EUR 168
Description: IC50: 0.006-0.10 ?MPD-1/PD-L1 inhibitor 1 is a PD-1/PD-L1 interaction inhibitor.Plenty of studies show that blocking the PD-1/PD-Ll interactions can lead to the restorage and augment of T cell activation in many systems.

PD-1/PD-L1 Inhibitor 2

B1050-25
EUR 566

PD-1/PD-L1 Inhibitor 2

B1050-5
EUR 202

PD-1/PD-L1 Inhibitor 1

B1213-25
EUR 566

PD-L1 Conjugated Antibody

C49251 100ul
EUR 397

B7-H1/PD-L1

E21-315 10ug
EUR 343

PD-L1 Blocking Peptide

20-abx161326
  • EUR 272.00
  • EUR 411.00
  • 1 mg
  • 5 mg
  • Shipped within 5-10 working days.

PD-L1 (CD274) siRNA

20-abx910978
  • EUR 551.00
  • EUR 732.00
  • 15 nmol
  • 30 nmol
  • Shipped within 5-10 working days.

PD-L1 (CD274) siRNA

20-abx910979
  • EUR 551.00
  • EUR 732.00
  • 15 nmol
  • 30 nmol
  • Shipped within 5-10 working days.

PD-L1 Rabbit pAb

A11273-100ul 100 ul
EUR 308

PD-L1 Rabbit pAb

A11273-200ul 200 ul
EUR 459

PD-L1 Rabbit pAb

A11273-20ul 20 ul
EUR 183

PD-L1 Rabbit pAb

A11273-50ul 50 ul
EUR 223

PD-L1 Rabbit pAb

A1645-100ul 100 ul
EUR 308

PD-L1 Rabbit pAb

A1645-200ul 200 ul
EUR 459

PD-L1 Rabbit pAb

A1645-20ul 20 ul
EUR 183

PD-L1 Rabbit pAb

A1645-50ul 50 ul
EUR 223

Mouse PD-L1 Antibody

32903-05111 150 ug
EUR 261

Polyclonal Goat Anti-CD274 / PD-L1 Antibody

APG00067G 0.1mg
EUR 484
Description: A polyclonal antibody raised in Goat that recognizes and binds to Human Goat Anti-CD274 / PD-L1 . This antibody is tested and proven to work in the following applications:

Rabbit Anti-Human PD-L1 monoclonal antibody

CABT-BL8451 100 ul
EUR 663

Rabbit Anti-Human PD-L1 monoclonal antibody

CABT-BL8452 100 ul
EUR 663

Anti-PD-L1/B7-H1/CD274 Antibody

A00109 100ug/vial
EUR 294

Anti-PD-L1 Monoclonal Antibody (Clone: ABM5F25)

A1537-50
EUR 305

Mouse Anti-Human CD274 (PD-L1) mAb

CM025-100ug 100ug
EUR 281

Mouse Anti-Human CD274 (PD-L1) mAb

CM025-25ug 25ug
EUR 165

Mouse Anti-Human CD274 (PD-L1) mAb

CM026-100ug 100ug
EUR 281

Mouse Anti-Human CD274 (PD-L1) mAb

CM026-25ug 25ug
EUR 165

Mouse Anti-Human CD274 (PD-L1) mAb

CM027-100ug 100ug
EUR 223

Mouse Anti-Human CD274 (PD-L1) mAb

CM027-25ug 25ug
EUR 151

Mouse Anti-Human CD274 (PD-L1) mAb

P1062-25ug 25ug
EUR 151

Anti-PD-L1 (CD274) Rabbit Monoclonal Antibody

M00109 100ug/vial
EUR 397
Description: Rabbit Monoclonal PD-L1 (CD274) Antibody. Validated in IHC-P, WB and tested in Human, Mouse, Rat.

Anti-PD-L1 (Durvalumab), Human IgG1 Antibody

A2109-100 100 µg
EUR 510

Anti-PD-L1 (Avelumab), Human IgG1 Antibody

A2152-100 100 µg
EUR 510

Ribosome-inactivating protein PD-L1 / PD-L2 Antibody

20-abx319445
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.

Ribosome-inactivating protein PD-L1/PD-L2 Antibody

1-CSB-PA306294LA01PJJ
  • EUR 317.00
  • EUR 335.00
  • 100ug
  • 50ug
  • Form: Liquid
  • Buffer: Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 >95%, Protein G purified
Description: A polyclonal antibody against Ribosome-inactivating protein PD-L1/PD-L2. Recognizes Ribosome-inactivating protein PD-L1/PD-L2 from Phytolacca dioica. This antibody is Unconjugated. Tested in the following application: ELISA

PD-L1/B7-H1/CD274

E21-J88 10ug
EUR 343

PD-L1 /CD274, Human Recombinant

P1023-10
EUR 251

PD-L1 /CD274, Human Recombinant

P1023-50
EUR 686

Human PD-L1 Elisa Kit

QY-E05642 96T
EUR 361

Mouse Anti-Human CD274 (PD-L1) mAbConjugated Antibody

CCM025 100ul
EUR 397

Ribosome-Inactivating Protein PD-L1/PD-L2 Polyclonal Antibody

A64216 100 µg
EUR 570.55
Description: The best epigenetics products

Ribosome-inactivating protein PD-L1 / PD-L2 Antibody (HRP)

20-abx319446
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.

Ribosome-inactivating protein PD-L1 / PD-L2 Antibody (FITC)

20-abx319447
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.

Ribosome-inactivating protein PD-L1 / PD-L2 Antibody (Biotin)

20-abx319448
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.

Phytolacca dioica Ribosome-inactivating protein PD-L1/PD-L2

1-CSB-EP306294PJJ
  • EUR 611.00
  • EUR 309.00
  • EUR 1827.00
  • EUR 939.00
  • EUR 1218.00
  • EUR 397.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
  • MW: 45.2 kDa
  • Buffer composition: Tris-based buffer with 50% glycerol.
Description: Recombinant Phytolacca dioica Ribosome-inactivating protein PD-L1/PD-L2 expressed in E.coli

Mouse Anti-Human PD-L1 monoclonal antibody, clone JID522

CABT-L2928-100uL500uL 100 uL, 500 uL
EUR 502

Mouse Anti-PD-L1 IgG Monoclonal Antibody, Clone 3A9F12

7122 1 mg/ml x 0.1 ml
EUR 338.55
Description: Mouse Anti-PD-L1 IgG Monoclonal Antibody

Anti-PD-L1 (CD274) (B7-H1), Rabbit Monoclonal Antibody

A1824-50 Ask for price

Anti-CD274/ PD-L1 Antibody [10F.9G2], Unconjugated-100ug

QAB95-100ug 100ug
EUR 191

Anti-CD274/ PD-L1 Antibody [10F.9G2], PE-100ug

QAB95-PE-100ug 100ug
EUR 216

Anti-CD274/ PD-L1 Antibody [10F.9G2], PE-25ug

QAB95-PE-25ug 25ug
EUR 123

PD-L1, His (HEK293-expressed), Human

HY-P7398 100ug
EUR 291

[KO Validated] PD-L1 Rabbit mAb

A19135-100ul 100 ul
EUR 410

[KO Validated] PD-L1 Rabbit mAb

A19135-200ul 200 ul
EUR 571

[KO Validated] PD-L1 Rabbit mAb

A19135-20ul 20 ul
EUR 221

[KO Validated] PD-L1 Rabbit mAb

A19135-50ul 50 ul
EUR 287

Mouse PD-L1 Antibody (Biotin Conjugate)

32903-05121 150 ug
EUR 369

PD-L1/CD274 (Human) ELISA Kit

K4155-100
EUR 805

Ribosome-inactivating protein PD-L1/PD-L2 Antibody, HRP conjugated

1-CSB-PA306294LB01PJJ
  • EUR 317.00
  • EUR 335.00
  • 100ug
  • 50ug
  • Form: Liquid
  • Buffer: Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 >95%, Protein G purified
Description: A polyclonal antibody against Ribosome-inactivating protein PD-L1/PD-L2. Recognizes Ribosome-inactivating protein PD-L1/PD-L2 from Phytolacca dioica. This antibody is HRP conjugated. Tested in the following application: ELISA

Ribosome-inactivating protein PD-L1/PD-L2 Antibody, FITC conjugated

1-CSB-PA306294LC01PJJ
  • EUR 317.00
  • EUR 335.00
  • 100ug
  • 50ug
  • Form: Liquid
  • Buffer: Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 >95%, Protein G purified
Description: A polyclonal antibody against Ribosome-inactivating protein PD-L1/PD-L2. Recognizes Ribosome-inactivating protein PD-L1/PD-L2 from Phytolacca dioica. This antibody is FITC conjugated. Tested in the following application: ELISA

Ribosome-inactivating protein PD-L1/PD-L2 Antibody, Biotin conjugated

1-CSB-PA306294LD01PJJ
  • EUR 317.00
  • EUR 335.00
  • 100ug
  • 50ug
  • Form: Liquid
  • Buffer: Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 >95%, Protein G purified
Description: A polyclonal antibody against Ribosome-inactivating protein PD-L1/PD-L2. Recognizes Ribosome-inactivating protein PD-L1/PD-L2 from Phytolacca dioica. This antibody is Biotin conjugated. Tested in the following application: ELISA

Anti-CD274/ PD-L1 Antibody [10F.9G2], Qfluor 630-100ug

QAB95-QF630-100ug 100ug
EUR 259

Ribosome-Inactivating Protein PD-L1/PD-L2 Polyclonal Antibody, HRP Conjugated

A64217 100 µg
EUR 570.55
Description: kits suitable for this type of research

Ribosome-Inactivating Protein PD-L1/PD-L2 Polyclonal Antibody, FITC Conjugated

A64218 100 µg
EUR 570.55
Description: fast delivery possible

Ribosome-Inactivating Protein PD-L1/PD-L2 Polyclonal Antibody, Biotin Conjugated

A64219 100 µg
EUR 570.55
Description: reagents widely cited

Polyclonal B7-H1 / PD-L1 / CD274 Antibody

APR03374G 0.05ml
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human B7-H1 / PD-L1 / CD274 . This antibody is tested and proven to work in the following applications:

PD-L1/B7-H1/CD274 (C-mFc)

E21-M06 10ug
EUR 343

PD-L1/B7-H1/CD274 (C-Flag)

E21-M33 10ug
EUR 343

PD-L1/B7-H1/CD274(Fc fusion)

E21-M79 10ug
EUR 343

PD-L1, Fc Chimera (CHO-expressed), Human

HY-P7397 100ug
EUR 291

Mouse PD-L1 AssayLite Antibody (FITC Conjugate)

32903-05141 150 ug
EUR 428

Mouse PD-L1 AssayLite Antibody (RPE Conjugate)

32903-05151 150 ug
EUR 428

Mouse PD-L1 AssayLite Antibody (APC Conjugate)

32903-05161 150 ug
EUR 428

Mouse PD-L1 AssayLite Antibody (PerCP Conjugate)

32903-05171 150 ug
EUR 471

Human CellExp? Biotinylated PD-L1, Human Recombinant

P1422-10
EUR 262

Human CellExp? Biotinylated PD-L1, Human Recombinant

P1422-50
EUR 697

Recombinant Human PD-L1/B7-H1 Protein

RP00068 5 μg
EUR 136

Recombinant Human PD-L1/B7-H1 Protein

RP00184 10 μg
EUR 149

Recombinant Mouse PD-L1/B7-H1 Protein

RP01149 10 μg
EUR 155

Recombinant Mouse PD-L1/B7-H1 Protein

RP01158 20 μg
EUR 183

TranslationBlocker Human PD-L1/ CD274 siRNA, 10nmol

QX7-10nmol 10nmol
EUR 377

TranslationBlocker Human PD-L1/ CD274 siRNA, 2nmol

QX7-2nmol 2nmol
EUR 276

Recombinant PD-L1 Protein (Met1-Arg238) [His]

VAng-Cr3817-100g 100 µg
EUR 734
Description: Recombinant PD-L1 Protein (Met1-Arg238) fused with a His tag at C-terminus was expressed in Mammalian cells, with a molecular weight of 35 kDa. (Uniprot ID: Q9NZQ7)

Rabbit Polyclonal antibody Anti-CRBN

Anti-CRBN 50 µg
EUR 349

Anti-PD-L1 (CD274) (B7-H1) Rabbit Monoclonal Antibody, Clone#RM320

M00109-1 100uL
EUR 427
Description: Anti-PD-L1 (CD274) (B7-H1) Rabbit Monoclonal Antibody, Clone#RM320 tested in WB, IHC, reactive to Human

Recombinant Cynomolgus CD274 molecule/PD-L1(C-Fc)

CA94-10ug 10ug
EUR 141
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.

Recombinant Cynomolgus CD274 molecule/PD-L1(C-Fc)

CA94-1mg 1mg
EUR 1877
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.

Recombinant Cynomolgus CD274 molecule/PD-L1(C-Fc)

CA94-500ug 500ug
EUR 1328
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.

Recombinant Cynomolgus CD274 molecule/PD-L1(C-Fc)

CA94-50ug 50ug
EUR 303
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.

Human PD-L1/B7-H1 PicoKine ELISA Kit

EK1449 96 wells
EUR 425
Description: For quantitative detection of human PD-L1 in cell culture supernates, cell lysates, serum and plasma (heparin, EDTA).

Mouse PD-L1/B7-H1 PicoKine ELISA Kit

EK1450 96 wells
EUR 425
Description: For quantitative detection of mouse PD-L1 in cell culture supernates, cell lysates, serum and plasma (heparin, EDTA).

ELISA kit for Human PD-L1/B7-H1

EK5678 96 tests
EUR 553
Description: Enzyme-linked immunosorbent assay kit for quantification of Human PD-L1/B7-H1 in samples from serum, plasma, tissue homogenates and other biological fluids.

ELISA kit for Mouse PD-L1/B7-H1

EK5679 96 tests
EUR 553
Description: Enzyme-linked immunosorbent assay kit for quantification of Mouse PD-L1/B7-H1 in samples from serum, plasma, tissue homogenates and other biological fluids.

QuickDetect? PD-L1/B7-H1 (Human) ELISA Kit

K4416-100
EUR 914

Recombinant Rat PD-L1/B7-H1/CD274 Protein

RP00800 10 μg
EUR 174

pGL3-Basic-PD-L1 promoter(-1000~+200) Plasmid

PVTB00385-2a 2 ug
EUR 356

pGL3-Basic-PD-L1 promoter(-800~+200) Plasmid

PVTB00385-2b 2 ug
EUR 356

pGL3-Basic-PD-L1 promoter(-600~+200) Plasmid

PVTB00385-2c 2 ug
EUR 356

pGL3-Basic-PD-L1 promoter(-400~+200) Plasmid

PVTB00385-2d 2 ug
EUR 356

pGL3-Basic-PD-L1 promoter(-200~+200) Plasmid

PVTB00385-2e 2 ug
EUR 356

pGL3-Basic-PD-L1 promoter(0~+200) Plasmid

PVTB00385-2f 2 ug
EUR 356

Rat Anti-Mouse PD-L1 (B7-H1) Monoclonal antibody, clone 10F.9G2

CABT-L4404-1mg 1 mg
EUR 897

Rat Anti-Mouse PD-L1 (B7-H1) Monoclonal antibody, clone 10F.9G2

CABT-L4404-5mg 5 mg
EUR 2405

Mouse Anti-Human PD-L1 (B7-H1) Monoclonal antibody, clone 29E.2A3

CABT-L4518-1mg 1 mg
EUR 897

Mouse Anti-Human PD-L1 (B7-H1) Monoclonal antibody, clone 29E.2A3

CABT-L4518-5mg 5 mg
EUR 2405

Recombinant Human PD-L1/B7-H1/CD274 (C-6His)

C315-10ug 10ug
EUR 90
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, 5% Trehalose, pH 7.4.

Recombinant Human PD-L1/B7-H1/CD274 (C-6His)

C315-1mg 1mg
EUR 1166
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, 5% Trehalose, pH 7.4.

Recombinant Human PD-L1/B7-H1/CD274 (C-6His)

C315-500ug 500ug
EUR 831
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, 5% Trehalose, pH 7.4.

Recombinant Human PD-L1/B7-H1/CD274 (C-6His)

C315-50ug 50ug
EUR 171
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, 5% Trehalose, pH 7.4.

Programmed Cell Death 1 Ligand 1 (PD-L1) Antibody

20-abx125632
  • EUR 411.00
  • EUR 592.00
  • EUR 182.00
  • EUR 314.00
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul
  • Shipped within 5-10 working days.

Programmed Cell Death 1 Ligand 1 (PD-L1) Antibody

20-abx111472
  • EUR 732.00
  • EUR 398.00
  • 150 ul
  • 50 ul
  • Shipped within 5-10 working days.

Programmed Cell Death 1 Ligand 1 (PD-L1) Antibody

20-abx121326
  • EUR 300.00
  • EUR 439.00
  • EUR 189.00
  • 100 ul
  • 200 ul
  • 30 ul
  • Shipped within 5-10 working days.

Programmed Cell Death 1 Ligand 1 (PD-L1) Antibody

20-abx001385
  • EUR 411.00
  • EUR 592.00
  • EUR 182.00
  • EUR 314.00
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul
  • Shipped within 5-10 working days.

Programmed Cell Death 1 Ligand 1 (PD-L1) Antibody

20-abx320158
  • EUR 300.00
  • EUR 244.00
  • 100 ul
  • 50 ul
  • Shipped within 5-10 working days.

Programmed Cell Death 1 Ligand 1 (PD-L1) Antibody

abx430491-200ul 200 ul
EUR 384
  • Shipped within 1-3 working days.

Programmed Cell Death 1 Ligand 1 (PD-L1) Antibody

abx236280-100ug 100 ug
EUR 481
  • Shipped within 5-12 working days.

Programmed Cell Death 1 Ligand 1 (PD-L1) Antibody

abx236281-100ug 100 ug
EUR 509
  • Shipped within 5-12 working days.

Human CellExp? PD-L1 /CD274 /B7-H1, mouse recombinant

7428-10
EUR 278

Human CellExp? PD-L1 /CD274 /B7-H1, mouse recombinant

7428-50
EUR 718

Human CellExp? PD-L1 /CD274 /B7-H1, human recombinant

7429-10
EUR 224

Human CellExp? PD-L1 /CD274 /B7-H1, human recombinant

7429-1000 Ask for price

Human CellExp? PD-L1 /CD274 /B7-H1, human recombinant

7429-250
EUR 2159

Human CellExp? PD-L1 /CD274 /B7-H1, human recombinant

7429-50
EUR 604

Recombinant Mouse PD-L1/B7-H1/CD274 (C-6His)

CJ88-10ug 10ug
EUR 100
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.

Recombinant Mouse PD-L1/B7-H1/CD274 (C-6His)

CJ88-1mg 1mg
EUR 1115
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.

Recombinant Mouse PD-L1/B7-H1/CD274 (C-6His)

CJ88-500ug 500ug
EUR 709
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.

Recombinant Mouse PD-L1/B7-H1/CD274 (C-6His)

CJ88-50ug 50ug
EUR 156
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.

Recombinant Mouse PD-L1/B7-H1/CD274 (C-Fc)

CJ89-10ug 10ug
EUR 100
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.

Recombinant Mouse PD-L1/B7-H1/CD274 (C-Fc)

CJ89-1mg 1mg
EUR 1115
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.

Recombinant Mouse PD-L1/B7-H1/CD274 (C-Fc)

CJ89-500ug 500ug
EUR 709
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.

Recombinant Mouse PD-L1/B7-H1/CD274 (C-Fc)

CJ89-50ug 50ug
EUR 156
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.

Recombinant Human PD-L1/B7-H1/CD274 (C-mFc)

CM06-10ug 10ug
EUR 115
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.

Recombinant Human PD-L1/B7-H1/CD274 (C-mFc)

CM06-1mg 1mg
EUR 1674
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.

Recombinant Human PD-L1/B7-H1/CD274 (C-mFc)

CM06-500ug 500ug
EUR 1186
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.

Recombinant Human PD-L1/B7-H1/CD274 (C-mFc)

CM06-50ug 50ug
EUR 202
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.

Recombinant Human PD-L1/B7-H1/CD274 (C-Flag)

CM33-10ug 10ug
EUR 115
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB 150mM Nacl pH 7.4.

Recombinant Human PD-L1/B7-H1/CD274 (C-Flag)

CM33-1mg 1mg
EUR 1674
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB 150mM Nacl pH 7.4.

Recombinant Human PD-L1/B7-H1/CD274 (C-Flag)

CM33-500ug 500ug
EUR 1186
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB 150mM Nacl pH 7.4.

Recombinant Human PD-L1/B7-H1/CD274 (C-Flag)

CM33-50ug 50ug
EUR 202
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB 150mM Nacl pH 7.4.

Recombinant Human PD-L1/B7-H1/CD274(C-Fc)

CM79-10ug 10ug
EUR 115
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH7.4.

Recombinant Human PD-L1/B7-H1/CD274(C-Fc)

CM79-1mg 1mg
EUR 1674
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH7.4.

Recombinant Human PD-L1/B7-H1/CD274(C-Fc)

CM79-500ug 500ug
EUR 1186
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH7.4.

Recombinant Human PD-L1/B7-H1/CD274(C-Fc)

CM79-50ug 50ug
EUR 202
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH7.4.

Recombinant Human PD-L1 Protein (aa 1-239) [Fc]

VAng-Cr4033-100g 100 µg
EUR 1027
Description: Recombinant Human PD-L1 Protein (Met1-Thr 239) fused with a Fc tag at C-terminus was expressed in HEK293 Cells, with a molecular weight of 52 kDa. (Accession ID: NP_054862.1)

Recombinant Human PD-L1 Protein (aa 1-239) [Fc]

VAng-Cr4033-200g 200 µg
EUR 1687
Description: Recombinant Human PD-L1 Protein (Met1-Thr 239) fused with a Fc tag at C-terminus was expressed in HEK293 Cells, with a molecular weight of 52 kDa. (Accession ID: NP_054862.1)

Recombinant Cynomolgus PD-L1 Protein (aa 1-239) [Fc]

VAng-Cr4034-100g 100 µg
EUR 1137
Description: Recombinant Cynomolgus PD-L1 Protein (Met1-Thr 239) fused with a Fc tag at C-terminus was expressed in HEK293 Cells, with a molecular weight of 52.3 kDa. (Accession ID: XP_015292694.1)

Recombinant Cynomolgus PD-L1 Protein (aa 1-239) [Fc]

VAng-Cr4034-200g 200 µg
EUR 1687
Description: Recombinant Cynomolgus PD-L1 Protein (Met1-Thr 239) fused with a Fc tag at C-terminus was expressed in HEK293 Cells, with a molecular weight of 52.3 kDa. (Accession ID: XP_015292694.1)

Recombinant Mouse PD-L1 Protein (aa 1-239) [Fc]

VAng-Cr4035-100g 100 µg
EUR 1027
Description: Recombinant Mouse PD-L1 Protein (Met1-His239) fused with a Fc tag at C-terminus was expressed in HEK293 Cells, with a molecular weight of 51.6 kDa. (Accession ID: NP_068693.1)

Recombinant Mouse PD-L1 Protein (aa 1-239) [Fc]

VAng-Cr4035-200g 200 µg
EUR 1687
Description: Recombinant Mouse PD-L1 Protein (Met1-His239) fused with a Fc tag at C-terminus was expressed in HEK293 Cells, with a molecular weight of 51.6 kDa. (Accession ID: NP_068693.1)

Recombinant Rat PD-L1 Protein (aa 1-238) [Fc]

VAng-Cr4036-100g 100 µg
EUR 1137
Description: Recombinant Rat PD-L1 Protein (Met1-Thr238) fused with a Fc tag at C-terminus was expressed in HEK293 Cells, with a molecular weight of 51.8 kDa. (Accession ID: NP_001178883.1)

Recombinant Rat PD-L1 Protein (aa 1-238) [Fc]

VAng-Cr4036-200g 200 µg
EUR 1687
Description: Recombinant Rat PD-L1 Protein (Met1-Thr238) fused with a Fc tag at C-terminus was expressed in HEK293 Cells, with a molecular weight of 51.8 kDa. (Accession ID: NP_001178883.1)

Recombinant Canine PD-L1 Protein (aa 1-236) [Fc]

VAng-Cr4037-100g 100 µg
EUR 1137
Description: Recombinant Canine PD-L1 Protein (Met1-Arg236) fused with a Fc tag at C-terminus was expressed in HEK293 Cells, with a molecular weight of 51.5 kDa. (Accession ID: XP_541302.4)

Recombinant Canine PD-L1 Protein (aa 1-236) [Fc]

VAng-Cr4037-200g 200 µg
EUR 1687
Description: Recombinant Canine PD-L1 Protein (Met1-Arg236) fused with a Fc tag at C-terminus was expressed in HEK293 Cells, with a molecular weight of 51.5 kDa. (Accession ID: XP_541302.4)

anti- PD-ECGF antibody

FNab06264 100µg
EUR 585
  • Immunogen: thymidine phosphorylase
  • Uniprot ID: P19971
  • Research Area: Metabolism, Cardiovascular, Cancer, Immunology, Developmental biology
Description: Antibody raised against PD-ECGF

Anti-PD-ECGF Antibody

A06329 100ul
EUR 397
Description: Rabbit Polyclonal Antibody for PD-ECGF Antibody (TYMP) detection.tested for IHC, WB in Human.

Anti-PD-1 Antibody

A1384-100
EUR 338

Anti-PD-1 Antibody

A1384-30T
EUR 146

Anti-PD-ECGF antibody

PAab06264 100 ug
EUR 412

Anti-PD-ECGF antibody

STJ96779 200 µl
EUR 197
Description: Rabbit polyclonal to PD-ECGF.

Anti-PD-L2 antibody

STJ98748 200 µl
EUR 197
Description: Rabbit polyclonal to PD-L2.

Anti-PD-1 antibody

STJ190081 200 µl
EUR 197
Description: Unconjugated Mouse monoclonal to PD-1 (AS1A13)

Programmed Cell Death 1 Ligand 1 (PD-L1) Antibody (Biotin)

abx430492-200ul 200 ul
EUR 384
  • Shipped within 1-3 working days.

Human Programmed Death Ligand-1(PD-L1/CD274) ELISA Kit

CSB-E13644h-24T 1 plate of 24 wells
EUR 165
  • Sample volume: 50-100ul
  • Detection wavelength: 450nm
  • Assay performance time: 1 to 4 hours.
Description: Quantitativesandwich ELISA kit for measuring Human Programmed Death Ligand-1 (PD-L1/CD274) in samples from serum, plasma, tissue homogenates, cell lysates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Human Programmed Death Ligand-1(PD-L1/CD274) ELISA Kit

1-CSB-E13644h
  • EUR 804.00
  • EUR 5099.00
  • EUR 2704.00
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
  • Sample volume: 50-100ul
  • Detection wavelength: 450nm
  • Assay performance time: 1 to 4 hours.
Description: Quantitativesandwich ELISA kit for measuring Human Programmed Death Ligand-1(PD-L1/CD274) in samples from serum, plasma, tissue homogenates, cell lysates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

PD-L1 / PDCD1LG1 / CD274 / B7-H1; Clone PDL1/2746 (Concentrate)

RA0501-C.1 0.1 ml
EUR 125

PD-L1 / PDCD1LG1 / CD274 / B7-H1; Clone PDL1/2746 (Concentrate)

RA0501-C.5 0.5 ml
EUR 300

PD-L1 / PDCD1LG1 / CD274 / B7-H1; Clone PDL1/2746 (Concentrate)

RA0501-C1 1 ml
EUR 500
Antibodies didn’t have an effect on the motor efficiency or anxiousness scores in mice. These findings counsel that neuronal antibodies concentrating on completely different epitopes throughout the NMDA receptor could end in the same seizure phenotype.

Leave a Reply

Your email address will not be published. Required fields are marked *

Related Post