Design, synthesis, and evaluation of HIV-1 entry inhibitors based on broadly neutralizing antibody 447-52D and gp120 V3loop interactions

Design, synthesis, and evaluation of HIV-1 entry inhibitors based on broadly neutralizing antibody 447-52D and gp120 V3loop interactions
The third variable loop area (V3 loop) on gp120 performs an necessary position in mobile entry of HIV-1. Its interplay with the mobile CD4 and coreceptors is a crucial hallmark in facilitating the bridging by gp41 and subsequent fusion of membranes for switch of viral genetic materials. Additional, the virus phenotype determines the cell tropism by way of respective co- receptor binding.
Thus, coreceptor binding motif of envelope is taken into account to be a potent anti-viral drug goal for viral entry inhibition. Nonetheless, its excessive variability in sequence is the foremost hurdle for creating inhibitors concentrating on the area. On this examine, we have now used an in silico Digital Screening and “Fragment-based” methodology to design small molecules primarily based on the gp120 V3 loop interactions with a potent broadly neutralizing human monoclonal antibody, 447-52D.
From the in silico evaluation a potent scaffold, 1,3,5-triazine was recognized for additional growth. Derivatives of 1,3,5-triazine with particular useful teams have been designed and synthesized conserving the interplay with co-receptor intact. Lastly, preliminary analysis of molecules for HIV-1 inhibition on two completely different virus strains (clade C, clade B) yielded IC50 < 5.zero μM.
The method used to design molecules primarily based on broadly neutralizing antibody, was helpful for growth of goal particular potent antiviral brokers to forestall HIV entry. The examine reported promising inhibitors that might be additional developed and studied.

Cytokine antibody array-based evaluation of IL-37 therapy results in bronchial asthma

Bronchial asthma is pushed by group 2 innate lymphoid cells, antigen-specific CD4+ T helper sort 2 cells and their cytokines corresponding to interleukin (IL)-4, IL-5, IL-13. IL-37 is decreased in bronchial asthma and negatively associated to Th2 cytokines and different pro-inflammatory cytokines. Our examine confirmed that IL-37 degree in asthmatic peripheral blood mononuclear cells was decrease than in wholesome.
Additional, IL-37 was negatively correlated with exhaled nitric oxide, bronchial asthma management take a look at rating, atopy and rhinitis historical past in asthmatics. Then an OVA-induced bronchial asthma mice mannequin handled with rhIL-37 was established.
An antibody array was employed to uncover altered cytokines induced by IL-37 in mice lung tissue. 20 proteins differentially expressed after rhIL-37 therapy and 5 of them have been validated in asthmatic peripheral blood mononuclear cells. According to cytokine antibody array, CCL3, CCL4, CCL5 decreased after IL-37 administration. Whereas CXCL9 and CXCL13 have been no change. We concluded that IL-37 scale back asthmatic signs by inhibit pro-inflammatory cytokine corresponding to CCL3, CCL4, CCL5.

Editorial: The First Monoclonal Antibody Vaccine to Forestall Malaria Heralds a New Period of Malaria Vaccines to the Plasmodium falciparum Circumsporozoite Protein (PfCSP)

Malaria impacts greater than Three billion individuals in 95 nations, with an estimated mortality charge of 400,000 per 12 months. The feminine Anopheles spp mosquito mostly transmits malaria, and the primary burden of illness is because of Plasmodium falciparum. Essentially the most ample antigen on the sporozoite floor is the Plasmodium falciparum circumsporozoite protein (PfCSP).
PfCSP is required for parasite growth and attachment to host hepatocytes. The primary potential protein vaccine, RTS,S/ASO1, consists of a recombinant fusion antigen primarily based on PfCSP. Preliminary findings from a part Three trial of RTS,S/ASO1 have been promising however resulted in suggestions for additional analysis in large-scale trials. R21, a circumsporozoite protein-based vaccine, mixed with an adjuvant, Matrix-M (MM), was lately evaluated in a part 2 investigational examine in kids between 5-17 months of age in Burkina Faso.
The R21/MM candidate vaccine resulted in excessive titers of malaria-specific antibodies. On August 26, 2021, the findings from a part 1 trial on a brand new monoclonal antibody to PfCSP, CIS43LS, confirmed {that a} single dose of the CIS43LS monoclonal antibody resulted in safety towards malaria.
These new findings have implications for the seasonal management of malaria in endemic areas and a potential future position in public well being methods to get rid of malaria. This Editorial goals to supply the background to creating and evaluating the brand new malaria vaccines that focus on PfCSP, together with the primary monoclonal antibody vaccine to malaria.

Characterization and modulation of anti-αβTCR antibodies and their respective binding websites on the βTCR chain to complement engineered T cells

T cell engineering methods provide cures to sufferers and have entered scientific observe with chimeric antibody-based receptors; αβT cell receptor (αβTCR)-based methods are, nonetheless, lagging behind. To permit a extra speedy and profitable translation to profitable ideas additionally utilizing αβTCRs for engineering, incorporating a technique for the purification of genetically modified T cells, in addition to engineered T cell deletion after switch into sufferers, might be useful.
This might enable elevated efficacy, lowered potential unwanted side effects, and improved security of newly to-be-tested lead constructions. By characterizing the antigen-binding interface of a great manufacturing course of (GMP)-grade anti-αβTCR antibody, normally used for depletion of αβT cells from stem cell transplantation merchandise, we developed a method that permits for the purification of untouched αβTCR-engineered immune cells by altering 2 amino acids solely within the TCRβ chain fixed area of launched TCR chains.
Alternatively, we engineered an antibody that targets an prolonged mutated interface of 9 amino acids within the TCRβ chain fixed area and gives the chance to additional develop depletion methods of engineered immune cells.Design, synthesis, and evaluation of HIV-1 entry inhibitors based on broadly neutralizing antibody 447-52D and gp120 V3loop interactions

Monoclonal Antibodies From Anti-NMDA Receptor Encephalitis Affected person as a Software to Research Autoimmune Seizures

Anti-N-methyl-D-aspartate (NMDA) receptor encephalitis manifests with precipitous cognitive decline, irregular actions, and extreme seizures that may be difficult to manage with typical anti-seizure drugs. We beforehand demonstrated that intracerebroventricular (i.c.v.) administration of cerebrospinal fluid from affected sufferers, or purified NMDA receptor antibodies from encephalitis sufferers to mice precipitated seizures, thereby confirming that antibodies are straight pathogenic for seizures.
Though completely different repertoires of anti-NMDA receptor antibodies might contribute to the distinct scientific manifestations in encephalitis sufferers, the position of particular antibodies within the expression of seizure, motor, and cognitive phenotypes stays unclear. Utilizing three completely different patient-derived monoclonal antibodies with distinct epitopes throughout the N-terminal area (NTD) of the NMDA receptor, we characterised the seizure burden, motor exercise and anxiety-related conduct in mice.
We discovered that steady administration of 5F5, 2G6 or 3C11 antibodies for two weeks precipitated seizures, as measured with steady EEG utilizing cortical screw electrodes. The seizure burden was comparable in all three antibody-treated teams. The seizures have been accompanied by elevated hippocampal C-C chemokine ligand 2 (CCL2) mRNA expression Three days after antibody infusion had stopped.

Anti-PD-L1 Antibody

A1454-100 each
EUR 405.6

Anti-PD-L1 Antibody

A1454-30T each
EUR 175.2

Anti-PD-L1 antibody

STJ180217 0.1 ml
EUR 336

Anti-PD-L1 antibody

STJ180383 0.1 ml
EUR 295.2

Anti-PD-L1 antibody

STJ190082 200 µl
EUR 236.4
Description: Unconjugated Mouse monoclonal to PD-L1 (AS1A7)

Anti-PD-L1 antibody

STJ130022 50 µl
EUR 385.2
Description: Programmed death-ligand 1 (PD-L1) is a 40kDa type 1 transmembrane protein that suppresses immune system. PD-L1 is expressed in hematopoietic and nonhematopoietic cells including T cells and B cells and various types of tumor cells. PD-L1 binds to its receptor Programmed death 1 (PD1). During infection or inflammation, PD1PD-L1 interaction is important for preventing autoimmunity. In tumor microenvironments, PD1-PD-L1 interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human cancers. In recent years, PDL1 has become an important biomarker and immunotherapy target for many types of malignancies.

Anti-PD-L1 antibody

STJ130023 50 µl
EUR 385.2
Description: Programmed death-ligand 1 (PD-L1) is a 40kDa type 1 transmembrane protein that suppresses immune system. PD-L1 is expressed in hematopoietic and nonhematopoietic cells including T cells and B cells and various types of tumor cells. PD-L1 binds to its receptor Programmed death 1 (PD1). During infection or inflammation, PD1PD-L1 interaction is important for preventing autoimmunity. In tumor microenvironments, PD1-PD-L1 interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human cancers. In recent years, PDL1 has become an important biomarker and immunotherapy target for many types of malignancies.

Anti-PD-L1 antibody

STJ130024 50 µl
EUR 385.2
Description: Programmed death-ligand 1 (PD-L1) is a 40kDa type 1 transmembrane protein that suppresses immune system. PD-L1 is expressed in hematopoietic and nonhematopoietic cells including T cells and B cells and various types of tumor cells. PD-L1 binds to its receptor Programmed death 1 (PD1). During infection or inflammation, PD1PD-L1 interaction is important for preventing autoimmunity. In tumor microenvironments, PD1-PD-L1 interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human cancers. In recent years, PDL1 has become an important biomarker and immunotherapy target for many types of malignancies.

Rabbit anti PD-L1

E6TC00113 0.1mg
EUR 225
Description: Available in various conjugation types.

anti- PD-L1/CD274 antibody

FNab06280 100µg
EUR 606.3
Description: Antibody raised against PD-L1/CD274

anti- PD-L1/CD274 antibody

FNab06281 100µg
EUR 658.5
Description: Antibody raised against PD-L1/CD274

anti-PD-L1 VHH antibody

JOT0002-5 each Ask for price

anti-PD-L1 VHH antibody

JOT0002-5-1-100 100
EUR 148.12
Description: Primary VHH single domain antibody

anti-PD-L1 VHH antibody

JOT0002-5-1-1000 1000
EUR 880.6
Description: Primary VHH single domain antibody

anti-PD-L1 VHH antibody

JOT0002-5-1-2000 2000
EUR 1565.2
Description: Primary VHH single domain antibody

anti-PD-L1 VHH antibody

JOT0002-5-1-250 250
EUR 246.17
Description: Primary VHH single domain antibody

anti-PD-L1 VHH antibody

JOT0002-5-1-50 50
EUR 89.54
Description: Primary VHH single domain antibody

Anti-PD-L1/CD274 Antibody

PB9994 100ug/vial
EUR 352.8

Anti-PD-L1/CD274 Antibody

PB9154 100ug/vial
EUR 352.8

Anti-PD-L1/CD274 Antibody

PA1851 100ug/vial
EUR 352.8

Anti-PD-L1/CD274 antibody

PAab06280 100 ug
EUR 426

Anti-CD274 / PD-L1 antibody

STJ70646 100 µg
EUR 430.8

Anti-PD-L1 Antibody (IHC411)

A1549-50 each
EUR 222

Anti-PD-L1, PE-labeled

71128-1 50 µg
EUR 355
Description: R-Phycoerythrin-labeled anti-PD-L1 recombinant murine/human antibody recognizing the PD-1 binding region of human PD-L1. This antibody does not cross-react with mouse PD-L1, but does cross-react with monkey (M. fascicularis) PD-L1. It has not been tested with other species.

Anti-PD-L1, PE-labeled

71128-2 100 µg
EUR 510
Description: R-Phycoerythrin-labeled anti-PD-L1 recombinant murine/human antibody recognizing the PD-1 binding region of human PD-L1. This antibody does not cross-react with mouse PD-L1, but does cross-react with monkey (M. fascicularis) PD-L1. It has not been tested with other species.

PD-L1 / CD274 (GFP-tagged) - Mouse PD-L1 / CD274 antigen (PD-L1 / CD274)

MG203953 10 µg Ask for price

PD-L1 / CD274 (untagged) - Mouse PD-L1 / CD274 antigen (PD-L1 / CD274), (10ug)

MC201908 10 µg Ask for price

PD-L1 Antibody

4059-002mg 0.02 mg
EUR 206.18
Description: PD-L1 plays a critical role in induction and maintenance of immune tolerance to self. As a ligand for the inhibitory receptor PDCD1/CD279, PD-L1 modulates the activation threshold of T-cells and limits T-cell effector response (1). The PDCD1/CD279-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and facilitate tumor survival (2,3). Through a yet unknown activating receptor, it may costimulate T-cell subsets that predominantly produce interleukin-10 (IL10) (4).

PD-L1 Antibody

4059-01mg 0.1 mg
EUR 523.7
Description: PD-L1 plays a critical role in induction and maintenance of immune tolerance to self. As a ligand for the inhibitory receptor PDCD1/CD279, PD-L1 modulates the activation threshold of T-cells and limits T-cell effector response (1). The PDCD1/CD279-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and facilitate tumor survival (2,3). Through a yet unknown activating receptor, it may costimulate T-cell subsets that predominantly produce interleukin-10 (IL10) (4).

PD-L1 Antibody

49251-100ul 100ul
EUR 399.6

PD-L1 Antibody

49251-50ul 50ul
EUR 286.8

PD-L1 Antibody

P1013-01m 0.1m
EUR 224.4

PD-L1 Antibody

P1013-1ml 1ml
EUR 807.6

PD-L1 Antibody

R31573 100 ug
EUR 356.15
Description: Programmed death-ligand 1, also known as CD274 or B7-H1 is a protein that in humans is encoded by the CD274 gene. It is a 33-70kDa type 1 transmembrane protein that has been speculated to play a major role in suppressing the immune system during particular events such as pregnancy, tissue allografts, autoimmune disease and other disease states such as hepatitis. Upregulation on tumor MDCs downregulates T-cell immunity and PD-L1 blockade may represent an approach for cancer immunotherapy. It can provide positive costimulatory signals for innate and adaptive immunity and for protection against intracellular bacterial infection. It has been found that PD1/PDL1 pathway may be a good target for restoring antitumor immunity in ovarian cancer.

PD-L1 Antibody

R33263-100UG 100 ug
EUR 339.15
Description: Additional name(s) for this target protein: Programmed cell death 1 ligand 1; CD274

PD-L1 Antibody

DF6526 100ul
EUR 280
Description: Human,Mouse,Rat

PD-L1 Antibody

DF6526-100ul 100ul
EUR 280

PD-L1 Antibody

DF6526-200ul 200ul
EUR 350

PD-L1 Antibody

49251 100ul
EUR 499

PD-L1

E8ET1701-41 100ul
EUR 275
Description: Available in various conjugation types.

PD-L1 / CD274 (Myc-DDK-tagged) - Mouse PD-L1 / CD274 antigen (PD-L1 / CD274)

MR203953 10 µg Ask for price

Anti-PD-L1 Antibody [PD01-02]

HA721176 100ul
EUR 231
Description: PD-L1 (programmed-death ligand 1; CD274), is a transmembrane protein constitutionally expressed on a variety of cell types, including antigen presenting cells (dendritic cells and histiocytes) and some non-lymphoid tissues (heart and lung). Binding of PD-L1 to PD-1 (programmed-death 1; CD279) expressed by activated T-cells, inhibits their function, causing negative feedback control of immunological reactions, thus impeding inflammation and autoimmunity. Tumour cells may express PD-L1, which binds to PD-1 allowing cancer cells to evade the attack of T-cells. Blockade of the PD-1/PD-L1 pathway has now shown useful in therapy of multiple cancer types, causing durable tumour regressions in a substantial proportion of otherwise treatment refractory cases of melanoma, and carcinomas of e.g., lung, kidney, and urinary tract. Patients without tumour PD-L1 expression can also derive benefit from blocking agents (studies across multiple cancer types demonstrate a pooled response rate of 48% in patients with PD-L1-positive tumours compared to 15% in PD-L1-negative tumours). Tonsil and placenta can be used as positive and negative tissue controls. However, tonsil is found to be superior to placenta, as tonsil displayes a range of PD-L1 expression levels. Tonsil displayes the following reaction pattern: No staining reaction in the vast majority of lymphocytes including mantle zone and germinal centre B-cells, no staining reaction in superficial epithelial cells, a weak to moderate, typically punctuated membranous staining reaction of the majority of germinal centre macrophages and finally a moderate to strong staining reaction of the majority of epithelial crypt cells.

Anti-PD-L1 Antibody [JJ08-95]

ET1701-41 100ul
EUR 231
Description: Engagement of CD28 by B7-1 (CD80) or B7-2 (CD86) in the presence of antigen promotes T cell proliferation, cytokine production, differentiation of effector T cells, and the induction of Bcl-x, a promoter of T cell survival. Conversely, engagement of CTLA4 by B7-1 or B7-2 may inhibit proliferation and IL-2 production. Pdcd-1L1 (programmed cell death ligand-1), also known as B7-H1 or PD-L1, is 290 amino acid type I transmembrane protein which is 20% and 15% identical to B7-1 and B7-2, respectively. Pdcd-1L2 has immunoglobulin V-like and C-like domains and a 30 amino acid cytoplasmic tail. It does not bind CD28, cytotoxic T-lymphocyte A4 or ICOS (inducible co-stimulator). IL-2, although produced in small amounts, is required for the effect of Pdcd-1L1 co-stimulation. The gene which encodes Pdcd-1L1 maps to human chromosome 9p24. Pdcd-1L2 (programmed cell death ligand-2) is a 73 amino acid protein which contains a signal sequence, IgV- and IgC-like domains, a transmembrane region and a cytoplasmic region. The gene which encodes Pdcd-1L2 maps to human chromosome 9p24.2. The constitutive expression of Pdcd-1L1 and Pdcd-1L2 on paren-chymal cells of heart, lung and kidney suggests that the Pdcd-1-Pdcd-L system could provide unique negative signaling to help prevent autoimmune disease.

Anti-PD-L1 Antibody [JJ08-95]

ET1701-41TR 20ul
EUR 64.35
Description: Engagement of CD28 by B7-1 (CD80) or B7-2 (CD86) in the presence of antigen promotes T cell proliferation, cytokine production, differentiation of effector T cells, and the induction of Bcl-x, a promoter of T cell survival. Conversely, engagement of CTLA4 by B7-1 or B7-2 may inhibit proliferation and IL-2 production. Pdcd-1L1 (programmed cell death ligand-1), also known as B7-H1 or PD-L1, is 290 amino acid type I transmembrane protein which is 20% and 15% identical to B7-1 and B7-2, respectively. Pdcd-1L2 has immunoglobulin V-like and C-like domains and a 30 amino acid cytoplasmic tail. It does not bind CD28, cytotoxic T-lymphocyte A4 or ICOS (inducible co-stimulator). IL-2, although produced in small amounts, is required for the effect of Pdcd-1L1 co-stimulation. The gene which encodes Pdcd-1L1 maps to human chromosome 9p24. Pdcd-1L2 (programmed cell death ligand-2) is a 73 amino acid protein which contains a signal sequence, IgV- and IgC-like domains, a transmembrane region and a cytoplasmic region. The gene which encodes Pdcd-1L2 maps to human chromosome 9p24.2. The constitutive expression of Pdcd-1L1 and Pdcd-1L2 on paren-chymal cells of heart, lung and kidney suggests that the Pdcd-1-Pdcd-L system could provide unique negative signaling to help prevent autoimmune disease.

SensiStain™ Anti-PD-L1 Antibody

HY000271 0.1 ml
EUR 188.5

SensiStain™ Anti-PD-L1 Antibody

HY500011 0.1 ml
EUR 188.5

Mouse monoclona Anti-PD-L1 Antibody

TA355105 100 µg Ask for price

Anti-PD-L1 (CD274) Neutralizing Antibody

71213 100 µg
EUR 505
Description: Neutralizing recombinant chimeric murine/human monoclonal antibody recognizing the extracellular domain of PD-L1 and blocking the binding of PD-L1 to PD-1. This antibody has been shown to cross-react with mouse PD-L1. No other species have been tested.

Anti-CD274 / PD-L1, Biotinylated antibody

STJ73200 100 µg
EUR 430.8

Anti-PD-L1 (Atezolizumab), humanized Antibody

A1305-100 each
EUR 601.2

human anti-human PD-L1 mAb

E409C28-h100 100μL
EUR 395
Description: Available in various conjugation types.

mouse anti-human PD-L1 mAb

E409C28-m100 100μL
EUR 395
Description: Available in various conjugation types.

human anti-human PD-L1 mAb

E4A09L05 50ug
EUR 255
Description: Available in various conjugation types.

PD-L1 / CD274 (untagged)-Human PD-L1 / CD274 molecule (PD-L1 / CD274)

SC115168 10 µg Ask for price

PD-L1 / CD274 (GFP-tagged) - Human PD-L1 / CD274 molecule (PD-L1 / CD274)

RG213071 10 µg Ask for price

PD-L1 Antibody [F6A9]

SD8639-002mg 0.02 mg
EUR 253.22
Description: PD-L1 Antibody: Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antigen-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PD-L1 and PD-L2. PD-L1 is a B7-related protein that inhibits cell-mediated immune responses by reducing the secretion of IL-2 and IL-10 from memory T cells. This suggests that PD-L1 may be useful in reducing allogenic CD4+ memory T-cell responses to endothelial cells, thereby reducing the likelihood of host immune responses to allografts.

PD-L1 Antibody [F6A9]

SD8639-01mg 0.1 mg
EUR 723.62
Description: PD-L1 Antibody: Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antigen-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PD-L1 and PD-L2. PD-L1 is a B7-related protein that inhibits cell-mediated immune responses by reducing the secretion of IL-2 and IL-10 from memory T cells. This suggests that PD-L1 may be useful in reducing allogenic CD4+ memory T-cell responses to endothelial cells, thereby reducing the likelihood of host immune responses to allografts.

PD-L1 Antibody [F2G2]

SD8641-002mg 0.02 mg
EUR 253.22
Description: PD-L1 Antibody: Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antigen-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PD-L1 and PD-L2. PD-L1 is a B7-related protein that inhibits cell-mediated immune responses by reducing the secretion of IL-2 and IL-10 from memory T cells. This suggests that PD-L1 may be useful in reducing allogenic CD4+ memory T-cell responses to endothelial cells, thereby reducing the likelihood of host immune responses to allografts.

PD-L1 Antibody [F2G2]

SD8641-01mg 0.1 mg
EUR 723.62
Description: PD-L1 Antibody: Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antigen-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PD-L1 and PD-L2. PD-L1 is a B7-related protein that inhibits cell-mediated immune responses by reducing the secretion of IL-2 and IL-10 from memory T cells. This suggests that PD-L1 may be useful in reducing allogenic CD4+ memory T-cell responses to endothelial cells, thereby reducing the likelihood of host immune responses to allografts.

Mouse PD-L1 Antibody

32903-05111 150 ug
EUR 313.2

PD-L1/CD274 antibody

CAF50592-100ug 100ug
EUR 312

PD-L1 Conjugated Antibody

C49251 100ul
EUR 476.4

PD-L1 Monoclonal Antibody

CAC10271-100ul 100ul
EUR 367.5

PD-L1 Monoclonal Antibody

CAC10271-50ul 50ul
EUR 252

PD-L1 Polyclonal Antibody

E911273a 100ul
EUR 225
Description: Available in various conjugation types.

PD-L1 Polyclonal Antibody

29074 100ul
EUR 439

Anti-PD-L1/B7-H1/CD274 Antibody

A00109 100ug/vial
EUR 352.8

PE Anti-Mouse CD274/PD-L1 Antibody

DL21657F-20Tests 20Tests
EUR 152
Description: CD274, also known as B7-H1 or programmed death ligand 1 (PD-L1), is a 40 kD type I transmembrane protein and a member of the B7 family within the immunoglobulin receptor superfamily. It is expressed on T cells, B cells, NK cells, dendritic cells, IFN-γ activated endothelial cells, and monocytes. B7-H1 is one of the ligands of PD-1. The interaction of B7-H1 with PD-1 plays an important role in the inhibition of T cell responses. Other studies have shown that B7-H1 is able to costimulate T cell growth and cytokine production. CD274 is involved in costimulation essential for T cell proliferation and production of IL-10 and IFN-γ, in an IL-2-dependent and a PD-1-independent manner. Its interaction with PD-1 inhibits T cell proliferation and cytokine production.

PE Anti-Mouse CD274/PD-L1 Antibody

DL21657F-50Tests 50Tests
EUR 207.5
Description: CD274, also known as B7-H1 or programmed death ligand 1 (PD-L1), is a 40 kD type I transmembrane protein and a member of the B7 family within the immunoglobulin receptor superfamily. It is expressed on T cells, B cells, NK cells, dendritic cells, IFN-γ activated endothelial cells, and monocytes. B7-H1 is one of the ligands of PD-1. The interaction of B7-H1 with PD-1 plays an important role in the inhibition of T cell responses. Other studies have shown that B7-H1 is able to costimulate T cell growth and cytokine production. CD274 is involved in costimulation essential for T cell proliferation and production of IL-10 and IFN-γ, in an IL-2-dependent and a PD-1-independent manner. Its interaction with PD-1 inhibits T cell proliferation and cytokine production.

PE Anti-Mouse CD274/PD-L1 Antibody

DL21660F-25ug 25μg
EUR 200
Description: CD274, also known as B7-H1 or programmed death ligand 1 (PD-L1), is a 40 kD type I transmembrane protein and a member of the B7 family within the immunoglobulin receptor superfamily. It is expressed on T cells, B cells, NK cells, dendritic cells, IFN-γ activated endothelial cells, and monocytes. B7-H1 is one of the ligands of PD-1. The interaction of B7-H1 with PD-1 plays an important role in the inhibition of T cell responses. Other studies have shown that B7-H1 is able to costimulate T cell growth and cytokine production. CD274 is involved in costimulation essential for T cell proliferation and production of IL-10 and IFN-γ, in an IL-2-dependent and a PD-1-independent manner. Its interaction with PD-1 inhibits T cell proliferation and cytokine production.

PE Anti-Mouse CD274/PD-L1 Antibody

DL21660F-50ug 50μg
EUR 282.5
Description: CD274, also known as B7-H1 or programmed death ligand 1 (PD-L1), is a 40 kD type I transmembrane protein and a member of the B7 family within the immunoglobulin receptor superfamily. It is expressed on T cells, B cells, NK cells, dendritic cells, IFN-γ activated endothelial cells, and monocytes. B7-H1 is one of the ligands of PD-1. The interaction of B7-H1 with PD-1 plays an important role in the inhibition of T cell responses. Other studies have shown that B7-H1 is able to costimulate T cell growth and cytokine production. CD274 is involved in costimulation essential for T cell proliferation and production of IL-10 and IFN-γ, in an IL-2-dependent and a PD-1-independent manner. Its interaction with PD-1 inhibits T cell proliferation and cytokine production.

PE Anti-Human CD274/PD-L1 Antibody

DL21667F-20Tests 20Tests
EUR 192.5
Description: CD274, also known as PD-L1 and B7-H1, is type I transmembrane glycoprotein that serves as a ligand for CD279 (PD-1). This interaction is believed to regulate the balance between the stimulatory and inhibitory signals needed for responses to microbes and maintenance of self-tolerance. CD274 is involved in the costimulation of T cell proliferation and IL-10 and IFN-γ production in an IL-2-dependent and CD279-independent manner. Conflicting data has shown that CD274 can inhibit T cell proliferation and cytokine production, and alternatively, enhance T cell activation. Other studies suggest that CD274 may signal bidirectionally, raising interesting implications for its expression in a wide variety of cell types, including T and B cells, antigen-presenting cells, and nonhematopoietic cells.

PE Anti-Human CD274/PD-L1 Antibody

DL21667F-50Tests 50Tests
EUR 267.5
Description: CD274, also known as PD-L1 and B7-H1, is type I transmembrane glycoprotein that serves as a ligand for CD279 (PD-1). This interaction is believed to regulate the balance between the stimulatory and inhibitory signals needed for responses to microbes and maintenance of self-tolerance. CD274 is involved in the costimulation of T cell proliferation and IL-10 and IFN-γ production in an IL-2-dependent and CD279-independent manner. Conflicting data has shown that CD274 can inhibit T cell proliferation and cytokine production, and alternatively, enhance T cell activation. Other studies suggest that CD274 may signal bidirectionally, raising interesting implications for its expression in a wide variety of cell types, including T and B cells, antigen-presenting cells, and nonhematopoietic cells.

APC Anti-Mouse CD274/PD-L1 Antibody

DL21658F-20Tests 20Tests
EUR 162.5
Description: CD274, also known as B7-H1 or programmed death ligand 1 (PD-L1), is a 40 kD type I transmembrane protein and a member of the B7 family within the immunoglobulin receptor superfamily. It is expressed on T cells, B cells, NK cells, dendritic cells, IFN-γ activated endothelial cells, and monocytes. B7-H1 is one of the ligands of PD-1. The interaction of B7-H1 with PD-1 plays an important role in the inhibition of T cell responses. Other studies have shown that B7-H1 is able to costimulate T cell growth and cytokine production. CD274 is involved in costimulation essential for T cell proliferation and production of IL-10 and IFN-γ, in an IL-2-dependent and a PD-1-independent manner. Its interaction with PD-1 inhibits T cell proliferation and cytokine production.

APC Anti-Mouse CD274/PD-L1 Antibody

DL21658F-50Tests 50Tests
EUR 222.5
Description: CD274, also known as B7-H1 or programmed death ligand 1 (PD-L1), is a 40 kD type I transmembrane protein and a member of the B7 family within the immunoglobulin receptor superfamily. It is expressed on T cells, B cells, NK cells, dendritic cells, IFN-γ activated endothelial cells, and monocytes. B7-H1 is one of the ligands of PD-1. The interaction of B7-H1 with PD-1 plays an important role in the inhibition of T cell responses. Other studies have shown that B7-H1 is able to costimulate T cell growth and cytokine production. CD274 is involved in costimulation essential for T cell proliferation and production of IL-10 and IFN-γ, in an IL-2-dependent and a PD-1-independent manner. Its interaction with PD-1 inhibits T cell proliferation and cytokine production.

APC Anti-Mouse CD274/PD-L1 Antibody

DL21661F-25ug 25μg
EUR 200
Description: CD274, also known as B7-H1 or programmed death ligand 1 (PD-L1), is a 40 kD type I transmembrane protein and a member of the B7 family within the immunoglobulin receptor superfamily. It is expressed on T cells, B cells, NK cells, dendritic cells, IFN-γ activated endothelial cells, and monocytes. B7-H1 is one of the ligands of PD-1. The interaction of B7-H1 with PD-1 plays an important role in the inhibition of T cell responses. Other studies have shown that B7-H1 is able to costimulate T cell growth and cytokine production. CD274 is involved in costimulation essential for T cell proliferation and production of IL-10 and IFN-γ, in an IL-2-dependent and a PD-1-independent manner. Its interaction with PD-1 inhibits T cell proliferation and cytokine production.

APC Anti-Mouse CD274/PD-L1 Antibody

DL21661F-50ug 50μg
EUR 305
Description: CD274, also known as B7-H1 or programmed death ligand 1 (PD-L1), is a 40 kD type I transmembrane protein and a member of the B7 family within the immunoglobulin receptor superfamily. It is expressed on T cells, B cells, NK cells, dendritic cells, IFN-γ activated endothelial cells, and monocytes. B7-H1 is one of the ligands of PD-1. The interaction of B7-H1 with PD-1 plays an important role in the inhibition of T cell responses. Other studies have shown that B7-H1 is able to costimulate T cell growth and cytokine production. CD274 is involved in costimulation essential for T cell proliferation and production of IL-10 and IFN-γ, in an IL-2-dependent and a PD-1-independent manner. Its interaction with PD-1 inhibits T cell proliferation and cytokine production.

APC Anti-Human CD274/PD-L1 Antibody

DL21668F-20Tests 20Tests
EUR 192.5
Description: CD274, also known as PD-L1 and B7-H1, is type I transmembrane glycoprotein that serves as a ligand for CD279 (PD-1). This interaction is believed to regulate the balance between the stimulatory and inhibitory signals needed for responses to microbes and maintenance of self-tolerance. CD274 is involved in the costimulation of T cell proliferation and IL-10 and IFN-γ production in an IL-2-dependent and CD279-independent manner. Conflicting data has shown that CD274 can inhibit T cell proliferation and cytokine production, and alternatively, enhance T cell activation. Other studies suggest that CD274 may signal bidirectionally, raising interesting implications for its expression in a wide variety of cell types, including T and B cells, antigen-presenting cells, and nonhematopoietic cells.

APC Anti-Human CD274/PD-L1 Antibody

DL21668F-50Tests 50Tests
EUR 267.5
Description: CD274, also known as PD-L1 and B7-H1, is type I transmembrane glycoprotein that serves as a ligand for CD279 (PD-1). This interaction is believed to regulate the balance between the stimulatory and inhibitory signals needed for responses to microbes and maintenance of self-tolerance. CD274 is involved in the costimulation of T cell proliferation and IL-10 and IFN-γ production in an IL-2-dependent and CD279-independent manner. Conflicting data has shown that CD274 can inhibit T cell proliferation and cytokine production, and alternatively, enhance T cell activation. Other studies suggest that CD274 may signal bidirectionally, raising interesting implications for its expression in a wide variety of cell types, including T and B cells, antigen-presenting cells, and nonhematopoietic cells.

FITC Anti-Human CD274/PD-L1 Antibody

DL21666F-20Tests 20Tests
EUR 192.5
Description: CD274, also known as PD-L1 and B7-H1, is type I transmembrane glycoprotein that serves as a ligand for CD279 (PD-1). This interaction is believed to regulate the balance between the stimulatory and inhibitory signals needed for responses to microbes and maintenance of self-tolerance. CD274 is involved in the costimulation of T cell proliferation and IL-10 and IFN-γ production in an IL-2-dependent and CD279-independent manner. Conflicting data has shown that CD274 can inhibit T cell proliferation and cytokine production, and alternatively, enhance T cell activation. Other studies suggest that CD274 may signal bidirectionally, raising interesting implications for its expression in a wide variety of cell types, including T and B cells, antigen-presenting cells, and nonhematopoietic cells.

FITC Anti-Human CD274/PD-L1 Antibody

DL21666F-50Tests 50Tests
EUR 267.5
Description: CD274, also known as PD-L1 and B7-H1, is type I transmembrane glycoprotein that serves as a ligand for CD279 (PD-1). This interaction is believed to regulate the balance between the stimulatory and inhibitory signals needed for responses to microbes and maintenance of self-tolerance. CD274 is involved in the costimulation of T cell proliferation and IL-10 and IFN-γ production in an IL-2-dependent and CD279-independent manner. Conflicting data has shown that CD274 can inhibit T cell proliferation and cytokine production, and alternatively, enhance T cell activation. Other studies suggest that CD274 may signal bidirectionally, raising interesting implications for its expression in a wide variety of cell types, including T and B cells, antigen-presenting cells, and nonhematopoietic cells.

SensiStain™ Anti-PD-L1 - Tec Antibody

HY500122 0.1 ml
EUR 247

SensiStain™ Anti-PD-L1- IMF Antibody

HY500123 0.1 ml
EUR 247

Biotin Anti-Mouse CD274/PD-L1 Antibody

DL21656F-100ug 100μg
EUR 297.5
Description: CD274, also known as B7-H1 or programmed death ligand 1 (PD-L1), is a 40 kD type I transmembrane protein and a member of the B7 family within the immunoglobulin receptor superfamily. It is expressed on T cells, B cells, NK cells, dendritic cells, IFN-γ activated endothelial cells, and monocytes. B7-H1 is one of the ligands of PD-1. The interaction of B7-H1 with PD-1 plays an important role in the inhibition of T cell responses. Other studies have shown that B7-H1 is able to costimulate T cell growth and cytokine production. CD274 is involved in costimulation essential for T cell proliferation and production of IL-10 and IFN-γ, in an IL-2-dependent and a PD-1-independent manner. Its interaction with PD-1 inhibits T cell proliferation and cytokine production.

Biotin Anti-Mouse CD274/PD-L1 Antibody

DL21656F-50ug 50μg
EUR 215
Description: CD274, also known as B7-H1 or programmed death ligand 1 (PD-L1), is a 40 kD type I transmembrane protein and a member of the B7 family within the immunoglobulin receptor superfamily. It is expressed on T cells, B cells, NK cells, dendritic cells, IFN-γ activated endothelial cells, and monocytes. B7-H1 is one of the ligands of PD-1. The interaction of B7-H1 with PD-1 plays an important role in the inhibition of T cell responses. Other studies have shown that B7-H1 is able to costimulate T cell growth and cytokine production. CD274 is involved in costimulation essential for T cell proliferation and production of IL-10 and IFN-γ, in an IL-2-dependent and a PD-1-independent manner. Its interaction with PD-1 inhibits T cell proliferation and cytokine production.

Biotin Anti-Human CD274/PD-L1 Antibody

DL21665F-100ug 100μg
EUR 320
Description: CD274, also known as PD-L1 and B7-H1, is type I transmembrane glycoprotein that serves as a ligand for CD279 (PD-1). This interaction is believed to regulate the balance between the stimulatory and inhibitory signals needed for responses to microbes and maintenance of self-tolerance. CD274 is involved in the costimulation of T cell proliferation and IL-10 and IFN-γ production in an IL-2-dependent and CD279-independent manner. Conflicting data has shown that CD274 can inhibit T cell proliferation and cytokine production, and alternatively, enhance T cell activation. Other studies suggest that CD274 may signal bidirectionally, raising interesting implications for its expression in a wide variety of cell types, including T and B cells, antigen-presenting cells, and nonhematopoietic cells.

Biotin Anti-Human CD274/PD-L1 Antibody

DL21665F-25ug 25μg
EUR 170
Description: CD274, also known as PD-L1 and B7-H1, is type I transmembrane glycoprotein that serves as a ligand for CD279 (PD-1). This interaction is believed to regulate the balance between the stimulatory and inhibitory signals needed for responses to microbes and maintenance of self-tolerance. CD274 is involved in the costimulation of T cell proliferation and IL-10 and IFN-γ production in an IL-2-dependent and CD279-independent manner. Conflicting data has shown that CD274 can inhibit T cell proliferation and cytokine production, and alternatively, enhance T cell activation. Other studies suggest that CD274 may signal bidirectionally, raising interesting implications for its expression in a wide variety of cell types, including T and B cells, antigen-presenting cells, and nonhematopoietic cells.

Anti-PD-L1 (Avelumab), Human IgG1 Antibody

A2152-100 100 µg
EUR 612

Purified Anti-Mouse CD274/PD-L1 Antibody

DL21655F-100ug 100μg
EUR 230
Description: CD274, also known as B7-H1 or programmed death ligand 1 (PD-L1), is a 40 kD type I transmembrane protein and a member of the B7 family within the immunoglobulin receptor superfamily. It is expressed on T cells, B cells, NK cells, dendritic cells, IFN-γ activated endothelial cells, and monocytes. B7-H1 is one of the ligands of PD-1. The interaction of B7-H1 with PD-1 plays an important role in the inhibition of T cell responses. Other studies have shown that B7-H1 is able to costimulate T cell growth and cytokine production. CD274 is involved in costimulation essential for T cell proliferation and production of IL-10 and IFN-γ, in an IL-2-dependent and a PD-1-independent manner. Its interaction with PD-1 inhibits T cell proliferation and cytokine production.

Purified Anti-Mouse CD274/PD-L1 Antibody

DL21655F-50ug 50μg
EUR 170
Description: CD274, also known as B7-H1 or programmed death ligand 1 (PD-L1), is a 40 kD type I transmembrane protein and a member of the B7 family within the immunoglobulin receptor superfamily. It is expressed on T cells, B cells, NK cells, dendritic cells, IFN-γ activated endothelial cells, and monocytes. B7-H1 is one of the ligands of PD-1. The interaction of B7-H1 with PD-1 plays an important role in the inhibition of T cell responses. Other studies have shown that B7-H1 is able to costimulate T cell growth and cytokine production. CD274 is involved in costimulation essential for T cell proliferation and production of IL-10 and IFN-γ, in an IL-2-dependent and a PD-1-independent manner. Its interaction with PD-1 inhibits T cell proliferation and cytokine production.

Purified Anti-Human CD274/PD-L1 Antibody

DL21664F-100ug 100μg
EUR 275
Description: CD274, also known as PD-L1 and B7-H1, is type I transmembrane glycoprotein that serves as a ligand for CD279 (PD-1). This interaction is believed to regulate the balance between the stimulatory and inhibitory signals needed for responses to microbes and maintenance of self-tolerance. CD274 is involved in the costimulation of T cell proliferation and IL-10 and IFN-γ production in an IL-2-dependent and CD279-independent manner. Conflicting data has shown that CD274 can inhibit T cell proliferation and cytokine production, and alternatively, enhance T cell activation. Other studies suggest that CD274 may signal bidirectionally, raising interesting implications for its expression in a wide variety of cell types, including T and B cells, antigen-presenting cells, and nonhematopoietic cells.

Purified Anti-Human CD274/PD-L1 Antibody

DL21664F-25ug 25μg
EUR 155
Description: CD274, also known as PD-L1 and B7-H1, is type I transmembrane glycoprotein that serves as a ligand for CD279 (PD-1). This interaction is believed to regulate the balance between the stimulatory and inhibitory signals needed for responses to microbes and maintenance of self-tolerance. CD274 is involved in the costimulation of T cell proliferation and IL-10 and IFN-γ production in an IL-2-dependent and CD279-independent manner. Conflicting data has shown that CD274 can inhibit T cell proliferation and cytokine production, and alternatively, enhance T cell activation. Other studies suggest that CD274 may signal bidirectionally, raising interesting implications for its expression in a wide variety of cell types, including T and B cells, antigen-presenting cells, and nonhematopoietic cells.

Mouse Monoclonal Anti-PD-L1 Antibody [4F2]

TA355066 100 µg Ask for price

Mouse Monoclonal Anti-PD-L1 Antibody [2D6]

TA355069 100 µg Ask for price

Mouse Monoclonal Anti-PD-L1 Antibody [1D7]

TA355071 100 µg Ask for price

Polyclonal Goat Anti-CD274 / PD-L1 Antibody

APG00067G 0.1mg
EUR 580.8
Description: A polyclonal antibody raised in Goat that recognizes and binds to Human Goat Anti-CD274 / PD-L1 . This antibody is tested and proven to work in the following applications:

Anti-PD-L1 (Durvalumab), Human IgG1 Antibody

A2109-100 100 µg
EUR 612

Mouse Monoclonal Anti-PD-L1 Antibody [8E12]

TA355067 100 µg Ask for price

Mouse Monoclonal Anti-PD-L1 Antibody [6H10]

TA355068 100 µg Ask for price

Mouse Monoclonal Anti-PD-L1 Antibody [1F11]

TA355070 100 µg Ask for price

Rabbit Anti-Human PD-L1 monoclonal antibody

CABT-BL8451 100 ul
EUR 795.6

Rabbit Anti-Human PD-L1 monoclonal antibody

CABT-BL8452 100 ul
EUR 795.6

Anti-PD-L1 (CD274) Rabbit Monoclonal Antibody

M00109 100ug/vial
EUR 476.4
Description: Rabbit Monoclonal PD-L1 (CD274) Antibody. Validated in IHC-P, WB and tested in Human, Mouse, Rat.

Anti-PD-L1 Monoclonal Antibody (Clone: ABM5F25)

A1537-50 each
EUR 366

Anti-PD-L1 Neutralizing Antibody, Biotin-labeled

71214 100 µg
EUR 510
Description: Purified, recombinant, chimeric murine/human anti-PD-L1 (IgG1) antibody with C-terminal Avi-tag, expressed in HEK293 cells. Purified antibody was enzymatically biotinylated using Avitag™ technology. This antibody reacts with human PD-L1 and cross-reacts with mouse PD-L1. It has not been tested for cross-reactivity with other species.

PD-L1 Protein

20-abx261703
  • EUR 4101.60
  • EUR 393.60
  • EUR 276.00
  • 1 mg
  • 20 ug
  • 5 ug

PD-L1 Protein

20-abx263458
  • EUR 1930.80
  • EUR 393.60
  • EUR 276.00
  • 100 ug
  • 10 ug
  • 2 µg

PD-L1 (CD274)

100443-1 100 µg
EUR 320
Description: Human secreted Programmed Cell Death 1 Ligand 1 (PD-L1) protein, also known as CD274, PDCD1L1, and B7 homolog 1 (B7-H1), GenBank Accession No. NM_014143, a.a. 19-239, expressed in an E. coli expression system. MW = 25 kDa.

PD-L1 (CD274)

100443-2 1 mg
EUR 2720
Description: Human secreted Programmed Cell Death 1 Ligand 1 (PD-L1) protein, also known as CD274, PDCD1L1, and B7 homolog 1 (B7-H1), GenBank Accession No. NM_014143, a.a. 19-239, expressed in an E. coli expression system. MW = 25 kDa.

PD-L1 Peptide

4059P 0.05 mg
EUR 197.7
Description: (IN) PD-L1 peptide

PD-L1 Peptide

46-156P 0.1 mg
EUR 405.6
Description: CD274 / PD-L1 Peptide

PD-L1, CD274

E6TA00108 0.1mg
EUR 411.6

PD-L1 / CD274 (Myc-DDK-tagged)-Human PD-L1 / CD274 molecule (PD-L1 / CD274)

RC213071 10 µg Ask for price

Mouse Anti-Human CD274 (PD-L1) mAb

CM025-100ug 100ug
EUR 337.2

Mouse Anti-Human CD274 (PD-L1) mAb

CM025-25ug 25ug
EUR 198

Mouse Anti-Human CD274 (PD-L1) mAb

CM026-100ug 100ug
EUR 337.2

Mouse Anti-Human CD274 (PD-L1) mAb

CM026-25ug 25ug
EUR 198

Mouse Anti-Human CD274 (PD-L1) mAb

CM027-100ug 100ug
EUR 267.6

Mouse Anti-Human CD274 (PD-L1) mAb

CM027-25ug 25ug
EUR 181.2

Mouse Anti-Human CD274 (PD-L1) mAb

P1062-25ug 25ug
EUR 181.2

PD-1/PD-L1 Inhibitor 2

B1050-25 each
EUR 679.2

PD-1/PD-L1 Inhibitor 2

B1050-5 each
EUR 242.4

PD-1/PD-L1 Inhibitor 1

B1213-25 each
EUR 679.2

PD-1/PD-L1 inhibitor 2

B6023-25 25 mg
EUR 525.6
Description: PD-1/PD-L1 inhibitor 2 is a PD-1/PD-L1 interaction inhibitor.

PD-1/PD-L1 inhibitor 2

B6023-5 5 mg
EUR 205.2
Description: PD-1/PD-L1 inhibitor 2 is a PD-1/PD-L1 interaction inhibitor.

PD-1/PD-L1 inhibitor 1

B6172-25 25 mg
EUR 543.6
Description: IC50: 0.006-0.10 ?MPD-1/PD-L1 inhibitor 1 is a PD-1/PD-L1 interaction inhibitor.Plenty of studies show that blocking the PD-1/PD-Ll interactions can lead to the restorage and augment of T cell activation in many systems.

PD-1/PD-L1 inhibitor 1

B6172-5 5 mg
EUR 201.6
Description: IC50: 0.006-0.10 ?MPD-1/PD-L1 inhibitor 1 is a PD-1/PD-L1 interaction inhibitor.Plenty of studies show that blocking the PD-1/PD-Ll interactions can lead to the restorage and augment of T cell activation in many systems.

PD-1/PD-L1-IN-NP19

T36900-10mg 10mg Ask for price
Description: PD-1/PD-L1-IN-NP19

PD-1/PD-L1-IN-NP19

T36900-1g 1g Ask for price
Description: PD-1/PD-L1-IN-NP19

PD-1/PD-L1-IN-NP19

T36900-1mg 1mg Ask for price
Description: PD-1/PD-L1-IN-NP19

PD-1/PD-L1-IN-NP19

T36900-50mg 50mg Ask for price
Description: PD-1/PD-L1-IN-NP19

PD-1/PD-L1-IN-NP19

T36900-5mg 5mg Ask for price
Description: PD-1/PD-L1-IN-NP19

PD-1/PD-L1-IN-25

T63329-10mg 10mg Ask for price
Description: PD-1/PD-L1-IN-25

PD-1/PD-L1-IN-25

T63329-1g 1g Ask for price
Description: PD-1/PD-L1-IN-25

PD-1/PD-L1-IN-25

T63329-1mg 1mg Ask for price
Description: PD-1/PD-L1-IN-25

PD-1/PD-L1-IN-25

T63329-50mg 50mg Ask for price
Description: PD-1/PD-L1-IN-25

PD-1/PD-L1-IN-25

T63329-5mg 5mg Ask for price
Description: PD-1/PD-L1-IN-25

PD-1/PD-L1-IN-22

T63607-10mg 10mg Ask for price
Description: PD-1/PD-L1-IN-22

PD-1/PD-L1-IN-22

T63607-1g 1g Ask for price
Description: PD-1/PD-L1-IN-22

PD-1/PD-L1-IN-22

T63607-1mg 1mg Ask for price
Description: PD-1/PD-L1-IN-22

PD-1/PD-L1-IN-22

T63607-50mg 50mg Ask for price
Description: PD-1/PD-L1-IN-22

PD-1/PD-L1-IN-22

T63607-5mg 5mg Ask for price
Description: PD-1/PD-L1-IN-22

PD-1/PD-L1-IN-15

T63614-10mg 10mg Ask for price
Description: PD-1/PD-L1-IN-15

PD-1/PD-L1-IN-15

T63614-1g 1g Ask for price
Description: PD-1/PD-L1-IN-15

PD-1/PD-L1-IN-15

T63614-1mg 1mg Ask for price
Description: PD-1/PD-L1-IN-15

PD-1/PD-L1-IN-15

T63614-50mg 50mg Ask for price
Description: PD-1/PD-L1-IN-15

PD-1/PD-L1-IN-15

T63614-5mg 5mg Ask for price
Description: PD-1/PD-L1-IN-15

PD-1/PD-L1-IN-16

T63948-10mg 10mg Ask for price
Description: PD-1/PD-L1-IN-16

PD-1/PD-L1-IN-16

T63948-1g 1g Ask for price
Description: PD-1/PD-L1-IN-16

PD-1/PD-L1-IN-16

T63948-1mg 1mg Ask for price
Description: PD-1/PD-L1-IN-16

PD-1/PD-L1-IN-16

T63948-50mg 50mg Ask for price
Description: PD-1/PD-L1-IN-16

PD-1/PD-L1-IN-16

T63948-5mg 5mg Ask for price
Description: PD-1/PD-L1-IN-16

PD-1/PD-L1-IN-20

T64086-10mg 10mg Ask for price
Description: PD-1/PD-L1-IN-20

PD-1/PD-L1-IN-20

T64086-1g 1g Ask for price
Description: PD-1/PD-L1-IN-20

PD-1/PD-L1-IN-20

T64086-1mg 1mg Ask for price
Description: PD-1/PD-L1-IN-20

PD-1/PD-L1-IN-20

T64086-50mg 50mg Ask for price
Description: PD-1/PD-L1-IN-20

PD-1/PD-L1-IN-20

T64086-5mg 5mg Ask for price
Description: PD-1/PD-L1-IN-20

PD-1/PD-L1-IN-14

T61929-10mg 10mg Ask for price
Description: PD-1/PD-L1-IN-14

PD-1/PD-L1-IN-14

T61929-1g 1g Ask for price
Description: PD-1/PD-L1-IN-14

PD-1/PD-L1-IN-14

T61929-1mg 1mg Ask for price
Description: PD-1/PD-L1-IN-14

PD-1/PD-L1-IN-14

T61929-50mg 50mg Ask for price
Description: PD-1/PD-L1-IN-14

PD-1/PD-L1-IN-14

T61929-5mg 5mg Ask for price
Description: PD-1/PD-L1-IN-14

PD-1/PD-L1-IN 6

T61968-10mg 10mg Ask for price
Description: PD-1/PD-L1-IN 6

PD-1/PD-L1-IN 6

T61968-1g 1g Ask for price
Description: PD-1/PD-L1-IN 6

PD-1/PD-L1-IN 6

T61968-1mg 1mg Ask for price
Description: PD-1/PD-L1-IN 6

PD-1/PD-L1-IN 6

T61968-50mg 50mg Ask for price
Description: PD-1/PD-L1-IN 6

PD-1/PD-L1-IN 6

T61968-5mg 5mg Ask for price
Description: PD-1/PD-L1-IN 6

PD-1/PD-L1-IN 5

T62193-10mg 10mg Ask for price
Description: PD-1/PD-L1-IN 5

PD-1/PD-L1-IN 5

T62193-1g 1g Ask for price
Description: PD-1/PD-L1-IN 5

PD-1/PD-L1-IN 5

T62193-1mg 1mg Ask for price
Description: PD-1/PD-L1-IN 5

PD-1/PD-L1-IN 5

T62193-50mg 50mg Ask for price
Description: PD-1/PD-L1-IN 5

PD-1/PD-L1-IN 5

T62193-5mg 5mg Ask for price
Description: PD-1/PD-L1-IN 5

PD-1/PD-L1-IN-17

T62501-10mg 10mg Ask for price
Description: PD-1/PD-L1-IN-17

PD-1/PD-L1-IN-17

T62501-1g 1g Ask for price
Description: PD-1/PD-L1-IN-17

PD-1/PD-L1-IN-17

T62501-1mg 1mg Ask for price
Description: PD-1/PD-L1-IN-17

PD-1/PD-L1-IN-17

T62501-50mg 50mg Ask for price
Description: PD-1/PD-L1-IN-17

PD-1/PD-L1-IN-17

T62501-5mg 5mg Ask for price
Description: PD-1/PD-L1-IN-17

PD-1/PD-L1-IN-10

T9616-10mg 10mg Ask for price
Description: PD-1/PD-L1-IN-10

PD-1/PD-L1-IN-10

T9616-1g 1g Ask for price
Description: PD-1/PD-L1-IN-10

PD-1/PD-L1-IN-10

T9616-1mg 1mg Ask for price
Description: PD-1/PD-L1-IN-10

PD-1/PD-L1-IN-10

T9616-50mg 50mg Ask for price
Description: PD-1/PD-L1-IN-10

PD-1/PD-L1-IN-10

T9616-5mg 5mg Ask for price
Description: PD-1/PD-L1-IN-10

PD-1/PD-L1-IN-9

T9651-10mg 10mg Ask for price
Description: PD-1/PD-L1-IN-9

PD-1/PD-L1-IN-9

T9651-1g 1g Ask for price
Description: PD-1/PD-L1-IN-9

PD-1/PD-L1-IN-9

T9651-1mg 1mg Ask for price
Description: PD-1/PD-L1-IN-9

PD-1/PD-L1-IN-9

T9651-50mg 50mg Ask for price
Description: PD-1/PD-L1-IN-9

PD-1/PD-L1-IN-9

T9651-5mg 5mg Ask for price
Description: PD-1/PD-L1-IN-9

PE/Cyanine5.5 Anti-Mouse CD274/PD-L1 Antibody

DL21659F-20Tests 20Tests
EUR 177.5
Description: CD274, also known as B7-H1 or programmed death ligand 1 (PD-L1), is a 40 kD type I transmembrane protein and a member of the B7 family within the immunoglobulin receptor superfamily. It is expressed on T cells, B cells, NK cells, dendritic cells, IFN-γ activated endothelial cells, and monocytes. B7-H1 is one of the ligands of PD-1. The interaction of B7-H1 with PD-1 plays an important role in the inhibition of T cell responses. Other studies have shown that B7-H1 is able to costimulate T cell growth and cytokine production. CD274 is involved in costimulation essential for T cell proliferation and production of IL-10 and IFN-γ, in an IL-2-dependent and a PD-1-independent manner. Its interaction with PD-1 inhibits T cell proliferation and cytokine production.

PE/Cyanine5.5 Anti-Mouse CD274/PD-L1 Antibody

DL21659F-50Tests 50Tests
EUR 237.5
Description: CD274, also known as B7-H1 or programmed death ligand 1 (PD-L1), is a 40 kD type I transmembrane protein and a member of the B7 family within the immunoglobulin receptor superfamily. It is expressed on T cells, B cells, NK cells, dendritic cells, IFN-γ activated endothelial cells, and monocytes. B7-H1 is one of the ligands of PD-1. The interaction of B7-H1 with PD-1 plays an important role in the inhibition of T cell responses. Other studies have shown that B7-H1 is able to costimulate T cell growth and cytokine production. CD274 is involved in costimulation essential for T cell proliferation and production of IL-10 and IFN-γ, in an IL-2-dependent and a PD-1-independent manner. Its interaction with PD-1 inhibits T cell proliferation and cytokine production.

PE/Cyanine5.5 Anti-Mouse CD274/PD-L1 Antibody

DL21662F-25ug 25μg
EUR 230
Description: CD274, also known as B7-H1 or programmed death ligand 1 (PD-L1), is a 40 kD type I transmembrane protein and a member of the B7 family within the immunoglobulin receptor superfamily. It is expressed on T cells, B cells, NK cells, dendritic cells, IFN-γ activated endothelial cells, and monocytes. B7-H1 is one of the ligands of PD-1. The interaction of B7-H1 with PD-1 plays an important role in the inhibition of T cell responses. Other studies have shown that B7-H1 is able to costimulate T cell growth and cytokine production. CD274 is involved in costimulation essential for T cell proliferation and production of IL-10 and IFN-γ, in an IL-2-dependent and a PD-1-independent manner. Its interaction with PD-1 inhibits T cell proliferation and cytokine production.

PE/Cyanine5.5 Anti-Mouse CD274/PD-L1 Antibody

DL21662F-50ug 50μg
EUR 357.5
Description: CD274, also known as B7-H1 or programmed death ligand 1 (PD-L1), is a 40 kD type I transmembrane protein and a member of the B7 family within the immunoglobulin receptor superfamily. It is expressed on T cells, B cells, NK cells, dendritic cells, IFN-γ activated endothelial cells, and monocytes. B7-H1 is one of the ligands of PD-1. The interaction of B7-H1 with PD-1 plays an important role in the inhibition of T cell responses. Other studies have shown that B7-H1 is able to costimulate T cell growth and cytokine production. CD274 is involved in costimulation essential for T cell proliferation and production of IL-10 and IFN-γ, in an IL-2-dependent and a PD-1-independent manner. Its interaction with PD-1 inhibits T cell proliferation and cytokine production.

PE/Cyanine5 Anti-Human CD274/PD-L1 Antibody

DL21669F-20Tests 20Tests
EUR 237.5
Description: CD274, also known as PD-L1 and B7-H1, is type I transmembrane glycoprotein that serves as a ligand for CD279 (PD-1). This interaction is believed to regulate the balance between the stimulatory and inhibitory signals needed for responses to microbes and maintenance of self-tolerance. CD274 is involved in the costimulation of T cell proliferation and IL-10 and IFN-γ production in an IL-2-dependent and CD279-independent manner. Conflicting data has shown that CD274 can inhibit T cell proliferation and cytokine production, and alternatively, enhance T cell activation. Other studies suggest that CD274 may signal bidirectionally, raising interesting implications for its expression in a wide variety of cell types, including T and B cells, antigen-presenting cells, and nonhematopoietic cells.

PE/Cyanine5 Anti-Human CD274/PD-L1 Antibody

DL21669F-50Tests 50Tests
EUR 335
Description: CD274, also known as PD-L1 and B7-H1, is type I transmembrane glycoprotein that serves as a ligand for CD279 (PD-1). This interaction is believed to regulate the balance between the stimulatory and inhibitory signals needed for responses to microbes and maintenance of self-tolerance. CD274 is involved in the costimulation of T cell proliferation and IL-10 and IFN-γ production in an IL-2-dependent and CD279-independent manner. Conflicting data has shown that CD274 can inhibit T cell proliferation and cytokine production, and alternatively, enhance T cell activation. Other studies suggest that CD274 may signal bidirectionally, raising interesting implications for its expression in a wide variety of cell types, including T and B cells, antigen-presenting cells, and nonhematopoietic cells.

PE/Cyanine7 Anti-Human CD274/PD-L1 Antibody

DL21670F-20Tests 20Tests
EUR 237.5
Description: CD274, also known as PD-L1 and B7-H1, is type I transmembrane glycoprotein that serves as a ligand for CD279 (PD-1). This interaction is believed to regulate the balance between the stimulatory and inhibitory signals needed for responses to microbes and maintenance of self-tolerance. CD274 is involved in the costimulation of T cell proliferation and IL-10 and IFN-γ production in an IL-2-dependent and CD279-independent manner. Conflicting data has shown that CD274 can inhibit T cell proliferation and cytokine production, and alternatively, enhance T cell activation. Other studies suggest that CD274 may signal bidirectionally, raising interesting implications for its expression in a wide variety of cell types, including T and B cells, antigen-presenting cells, and nonhematopoietic cells.

PE/Cyanine7 Anti-Human CD274/PD-L1 Antibody

DL21670F-50Tests 50Tests
EUR 335
Description: CD274, also known as PD-L1 and B7-H1, is type I transmembrane glycoprotein that serves as a ligand for CD279 (PD-1). This interaction is believed to regulate the balance between the stimulatory and inhibitory signals needed for responses to microbes and maintenance of self-tolerance. CD274 is involved in the costimulation of T cell proliferation and IL-10 and IFN-γ production in an IL-2-dependent and CD279-independent manner. Conflicting data has shown that CD274 can inhibit T cell proliferation and cytokine production, and alternatively, enhance T cell activation. Other studies suggest that CD274 may signal bidirectionally, raising interesting implications for its expression in a wide variety of cell types, including T and B cells, antigen-presenting cells, and nonhematopoietic cells.

Monoclonal Anti-PD-L1 Antibody, Mouse IgG1 (1G1)

HCB-Y128 20ul
EUR 1080.7
Description: Monoclonal Anti-PD-L1 Antibody, Mouse IgG1 (1G1) is expressed from Mouse Hybridoma.

PD-L1 / CD274 (GFP-tagged) - Homo sapiens PD-L1 / CD274molecule (PD-L1 / CD274), transcript variant 2

RG231972 10 µg Ask for price

PD-L1 / CD274 (untagged) - Homo sapiens PD-L1 / CD274 molecule (PD-L1 / CD274), transcript variant 2

SC330780 10 µg Ask for price

Mouse Anti-Human CD274 (PD-L1) mAbConjugated Antibody

CCM025 100ul
EUR 476.4
Antibodies didn’t have an effect on the motor efficiency or anxiousness scores in mice. These findings counsel that neuronal antibodies concentrating on completely different epitopes throughout the NMDA receptor could end in the same seizure phenotype.

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