Tumor-associated macrophages (TAMs) are key regulators of the complex interplay between cancer and the immune microenvironment. Tumor cell-derived spondin 2 (SPON2) is an extracellular matrix glycoprotein that has complicated roles
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BIN4, a Novel Component of the Plant DNA Topoisomerase VI ComplexBIN4, a Novel Component of the Plant DNA Topoisomerase VI Complex
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How plant organs grow to reach their final size is an important but largely unanswered question. Here, we describe an Arabidopsis thaliana mutant, brassinosteroid-insensitive4 (bin4), in which the growth of various organs is dramatically
Development of an alternative saliva test for diagnosis of SARS-CoV-2 using TRIzolDevelopment of an alternative saliva test for diagnosis of SARS-CoV-2 using TRIzol
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The use of saliva for the diagnosis of SARS-CoV-2 has shown to be a good alternative to nasopharyngeal swabs (NPS), since it permits self-collection, avoids the exposure of healthy persons
Brucella canis: An update on research and clinical managementBrucella canis: An update on research and clinical management
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In Canada, Brucella canis remains a potentially devastating infectious agent that is still considered uncommon, despite the increasing international movement of dogs. There may be a growing risk to the Canadian canine
Panbio rapid antigen test for SARS-CoV-2 has acceptable accuracy in symptomatic patients in primary health carePanbio rapid antigen test for SARS-CoV-2 has acceptable accuracy in symptomatic patients in primary health care
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Highligths • Most of patients with mild symptoms (up to 75%) and close contacts are visited and followed-up in primary health care centers or test sites. • The present study
Effect of Qiangji Jianli decoction on mitochondrial respiratory chain activity and expression of mitochondrial fusion and fission proteins in myasthenia gravis rats.Effect of Qiangji Jianli decoction on mitochondrial respiratory chain activity and expression of mitochondrial fusion and fission proteins in myasthenia gravis rats.
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Myasthenia gravis (MG) is an autoimmune neuromuscular illness characterised by the manufacturing of antibodies in opposition to acetylcholine receptors (AChRs). Qiangji Jianli (QJJL) decoction is an efficient conventional Chinese language medication (TCM)
Germinal center hypoxia in tumor-draining lymph nodes negatively regulates tumor-induced humoral immune responses in mouse models of breast cancerGerminal center hypoxia in tumor-draining lymph nodes negatively regulates tumor-induced humoral immune responses in mouse models of breast cancer
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Hypoxia develops in germinal facilities (GCs) induced by mannequin antigens; nevertheless, it’s unknown whether or not tumor-reactive GCs are additionally hypoxic. We recognized GC hypoxia in lymph nodes (LNs) draining
Clinicopathological Significance of Nerves in Esophageal CancerClinicopathological Significance of Nerves in Esophageal Cancer
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Nerves are rising promoters of most cancers development, however the innervation of esophageal most cancers and its clinicopathologic significance stay unclear. On this examine, nerves have been investigated by immunohistochemistry
Blocking ADAM17 Function with a Monoclonal Antibody Improves Sepsis Survival in a Murine Model of Polymicrobial SepsisBlocking ADAM17 Function with a Monoclonal Antibody Improves Sepsis Survival in a Murine Model of Polymicrobial Sepsis
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Sepsis is the fruits of hyperinflammation and immune suppression in response to extreme an infection. Neutrophils are crucial early responders to bacterial an infection however can grow to be extremely
Mathematical Models of Blood-Brain Barrier Transport of Monoclonal Antibodies Targeting the Transferrin Receptor and the Insulin ReceptorMathematical Models of Blood-Brain Barrier Transport of Monoclonal Antibodies Targeting the Transferrin Receptor and the Insulin Receptor
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We develop and analyze mathematical fashions for receptor-mediated transcytosis of monoclonal antibodies (MAb) focusing on the transferrin receptor (TfR) or the insulin receptor (IR), that are expressed on the blood-brain