A survey of pharmacokinetic bioanalytical methods in biosimilar biological license applications (BLAs) for the assessment of target and antidrug antibodies effects

A survey of pharmacokinetic bioanalytical methods in biosimilar biological license applications (BLAs) for the assessment of target and antidrug antibodies effects
The presence of circulating targets and antidrug antibodies can affect the power of a bioanalytical methodology to measure therapeutic protein (TP) focus related to exposure-response evaluations. This mission surveyed biosimilar submissions for his or her bioanalytical strategies. Survey outcomes revealed that 97% of pharmacokinetic strategies designed to measure theoretically free or partial-free TPs with respect to focus on certainly measured free or partial-free TPs when contemplating experimental testing outcomes for goal results.
Antidrug antibody impact is much less typically evaluated. The noticed development of measuring biologically lively types of TP is per the scientific understanding that pharmacokinetics of biologically lively kinds is extra more likely to be related to the medical responses and analysis of clinically significant variations to contribute to biosimilarity assessments.

Medical Options of Coexisting Anti-NMDAR and MOG Antibody-Related Encephalitis: A Systematic Evaluation and Meta-Evaluation

Coexisting anti-NMDAR and MOG antibody (anti-NMDAR-IgG+/MOG-IgG+)-associated encephalitis have garnered nice consideration. This research aimed to carry out a secondary evaluation to find out the medical options of this illness. We searched a number of databases for associated publications printed previous to April 2021. A pooled evaluation was carried out with the fixed-effects mannequin utilizing the Mante-Haenszel methodology (I 2 ≤ 50%), or the random-effects mannequin computed by the DerSimonian-Laird methodology (I 2 > 50%).
Stata software program (model 15.Zero SE) was used for the analyses. 9 observational research and 16 case stories (58 circumstances with anti-NMDAR-IgG+/MOG-IgG+, 21.0 [8.5, 29.0] years, male 58.6%) have been included. The incidences (95%CI) of anti-NMDAR-IgG+/MOG-IgG+ within the sufferers with serum MOG-IgG+ and CSF anti-NMDAR-IgG+ have been 0.09 (0.02-0.19) and 0.07 (0.01-0.19), respectively.
The median [IQR] of CSF anti-NMDAR antibody titer was 32 [10, 100], and the serum anti-MOG antibody titer was 100 [32, 320]. The distinguished medical signs have been encephalitic manifestations, together with seizures (56.9%) and irregular habits (51.7%), fairly than demyelinating manifestations, similar to speech dysfunction (34.5%) and optic neuritis (27.6%).
Relapse occurred in 63.4% of anti-NMDAR-IgG+/MOG-IgG+ sufferers, in whom 50.0% of circumstances relapsed with encephalitic manifestations, and 53.8% relapsed with demyelinating manifestations. The widespread MRI adjustments have been within the cortex or subcortex (70.7%) and brainstem (31.0%). 31.3% of sufferers introduced with unilateral cerebral cortical encephalitis with epilepsy and 12.5% displayed bilateral frontal cerebral cortex encephalitis.
Anti-NMDAR-IgG+/MOG-IgG+ sufferers confirmed extra frequent psychological habits (OR, 95%CI, 68.38, 1.36-3,434.37), involuntary motion (57.86, 2.53-1,325.11), sleep issues (195.00, 7.07-5,380.15), and leptomeninge lesions (7.32, 1.81-29.58), and fewer frequent optic neuritis (0.27, 0.09-0.83) in comparison with anti-NMDAR-IgG/MOG-IgG+ sufferers and introduced extra widespread relapse (5.63, 1.75-18.09), previous an infection (2.69, 1.03-7.02), subcortical lesions (116.60, 4.89-2,782.09), basal ganglia lesions (68.14, 2.99-1,554.27), brainstem lesions (24.09, 1.01-574.81), and spinal twine lesions (24.09, 1.01-574.81) in comparison with anti-NMDAR-IgG+/MOG-IgG. In conclusion, anti-NMDAR-IgG+/MOG-IgG+ was not often noticed, however the incidence price of relapse was very excessive. The general signs gave the impression to be much like these of NMDAR encephalitis.
A survey of pharmacokinetic bioanalytical methods in biosimilar biological license applications (BLAs) for the assessment of target and antidrug antibodies effects

Strategies to Determine Immunogenic Peptides in SARS-CoV-2 Spike and Protecting Monoclonal Antibodies in COVID-19 Sufferers

The extreme acute respiratory syndrome coronavirus 2 (SARS-CoV-2) an infection and the related COVID-19 illnesses are an rising risk to international public well being. Though appreciable scientific analysis on the immune, particularly antibody, responses to SARS-CoV-2 an infection have been carried out, further dominant epitopes and protecting antibodies are wanted for prognosis and remedy of COVID-19 sufferers.
Right here, two completely different phage libraries are used to establish immunogenic epitopes throughout the spike protein and monoclonal antibodies from COVID-19 sufferers. Three peptides are additional characterised within the receptor-binding motif (RBM) and measured their antibody ranges in COVID-19 sufferers, from which one identifies one most immunodominant epitope with the best antibody response in COVID-19 sufferers and in immunized mice.
Extra importantly, monoclonal antibodies particularly binding to this peptide remoted from COVID-19 sufferers have therapeutic potential to neutralize SARS-CoV-2 an infection. Thus, the approaches to systemically establish immunogenic peptides and immediately establish human monoclonal antibodies from sufferers will present helpful diagnostic and therapeutic instruments for COVID-19 and different rising infectious illnesses.
A survey of pharmacokinetic bioanalytical methods in biosimilar biological license applications (BLAs) for the assessment of target and antidrug antibodies effects

Inhabitants pharmacokinetics and pharmacodynamics of the neutralizing antibodies bamlanivimab and etesevimab in sufferers with delicate to average COVID-19 an infection

Bamlanivimab and etesevimab are neutralizing antibodies indicated for remedy of COVID-19 in sufferers with early delicate or average illness. We current using pharmacokinetic-pharmacodynamic (PK/PD) modeling that characterizes the timecourse of viral load obtained from 2970 sufferers from two section 2 medical trials. The mannequin was used for identification of optimum doses that may end in not less than 90% of sufferers reaching serum drug concentrations that ends in 90% of most drug impact (IC90) for not less than 28 days.
The serum IC90 (95% confidence interval) was estimated to be 4.2 (3.2, 4.3) µg/mL for bamlanivimab and 12.6 (9.7, 12.8) µg/mL for etesevimab. Noticed medical trial knowledge confirmed PK and PK/PD mannequin predictions that doses of 700 mg bamlanivimab and 1400 mg etesevimab would end in most discount in viral load, with no further impact seen at increased doses.
No dose adjustment is really helpful as age, intercourse, race, baseline viral load and hepatic impairment didn’t have a big influence on the PK of the antibodies. Earlier drug administration resulted in higher reductions in viral load, demonstrating the significance of receiving remedy as quickly as potential.
Relative to placebo, typical discount in viral load over a 7 day interval was estimated to be 80 or 93% (drug administered Four days or 1 days after the onset of signs, respectively), p<0.0001. PK/PD modeling and simulation was pivotal all through the drug growth and emergency use authorization course of.

Extending conventional antibody therapies: Novel discoveries in immunotherapy and medical functions

Immunotherapy has been properly considered one of many safer and antigen-specific anti-cancer therapies in comparison with first-generation chemotherapy. Since Coley’s discovery, researchers targeted on engineering novel antibody-based therapies. Together with synthetic and modified antibodies, similar to antibody fragments, antibody-drug conjugates, and artificial mimetics, the number of immunotherapy has been quickly increasing in the previous couple of many years.
A survey of pharmacokinetic bioanalytical methods in biosimilar biological license applications (BLAs) for the assessment of target and antidrug antibodies effects
Genetic and chemical modifications to monoclonal antibody have been introduced into academia, in vivo trials, and medical functions. Right here, we have now seemed round antibodies general. First, we elucidate the antibody construction and its cytotoxicity mechanisms. Second, sorts of therapeutic antibodies are introduced. Moreover, there’s a summarized record of US Meals and Drug Administration (FDA)-approved therapeutic antibodies and up to date medical trials.

Pig IgG

E61I023 1mg
EUR 411.6

Rat IgG

M1101-100 each
EUR 183.6

Rat IgG

M1101-1000 each
EUR 444

Goat IgG

31R-1051 10 mg
EUR 163.2
Description: Purified Goat IgG

Goat IgG

31-AG15 1 gram
EUR 684
Description: Purified Goat IgG

Goat IgG

M1102-100 each
EUR 183.6

Goat IgG

M1102-1000 each
EUR 444

Goat Anti-HIV gp41 IgG (poly) IgG

AB-16160 100 ul
EUR 534

Goat Anti-HIV gp120 IgG (poly) IgG

AB-16150 100 ul
EUR 534

Mouse IgG

1265-100 each
EUR 183.6

Mouse IgG

1265-1000 each
EUR 444

Human IgG

1269-100 each
EUR 183.6

Human IgG

1269-1000 each
EUR 444

Sheep IgG

31R-1050 20 mg
EUR 163.2
Description: Purified Sheep IgG

Mouse IgG

31-AM15 10 mg
EUR 258
Description: Purified Mouse IgG

Mouse IgG

31-AM15S 10 mg
EUR 156
Description: Purified Mouse IgG

Sheep IgG

31-AS25 100 mg
EUR 414
Description: Purified Sheep IgG

Human IgG

E3M00002 200ul
EUR 489.6

Mouse IgG

E61I007 1mg
EUR 411.6

Human IgG

E61I008 1mg
EUR 411.6

Sheep IgG

E61I019 1mg
EUR 411.6

Horse IgG

E61I024 1mg
EUR 411.6

GAP43 (IgG)

MO22171 100 µl
EUR 522

Human dsDNA IgG(dsDNA IgG) ELISA Kit

QY-E05613 96T
EUR 433.2

Rabbit IgG

1268-100 each
EUR 183.6

Rabbit IgG

1268-1000 each
EUR 444

Donkey IgG

31C-CH1601 10 mg
EUR 283.2
Description: Purified Donkey IgG

Rabbit IgG

31R-1049 10 mg
EUR 163.2
Description: Purified Rabbit IgG

Rabbit IgG

31R-AR002 25 mg
EUR 457.2
Description: Purified Rabbit IgG

Rabbit IgG

31-1007 1 g
EUR 420
Description: Purified IgG from rabbit serum

Bovine IgG

31-AB20 50 mg
EUR 264
Description: Purified Bovine IgG

Rabbit IgG

E61I018 1mg
EUR 411.6

Bovine IgG

QY-E60066 96T
EUR 511.2

Human Rotavirus IgG,RV IgG ELISA Kit

201-12-2138 96 tests
EUR 528
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Rat Leptospira IgG(Lep IgG)ELISA Kit

GA-E0268RT-48T 48T
EUR 380.4

Rat Leptospira IgG(Lep IgG)ELISA Kit

GA-E0268RT-96T 96T
EUR 595.2

Human Rotavirus IgG(RV IgG)ELISA Kit

QY-E02213 96T
EUR 433.2

Rat Leptospira IgG(Lep IgG)ELISA Kit

QY-E11384 96T
EUR 433.2

Rat Leptospira IgG,Lep IgG ELISA Kit

YLA0882RA-48T 48T
EUR 465

Rat Leptospira IgG,Lep IgG ELISA Kit

YLA0882RA-96T 96T
EUR 600

Goat Anti-Hamster IgG (H+L)-HRP conjugate (Syrian) IgG (Syrian) IgG

80320 1 ml
EUR 242.4

Porcine IgG

31-1008 1 g
EUR 321.6
Description: Purified Porcine IgG protein

IgG Protein

abx069984-1g 1 g
EUR 1980

Goat Anti-Human IgG (Fc) IgG, unlabeled

10119 1 mg
EUR 242.4

Goat Anti-Human IgG (Fc) IgG, unlabeled

10119-2 1 mg
EUR 270

Human Leptospira IgG,Lep IgG ELISA Kit

201-12-1798 96 tests
EUR 528
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Goat Anti-Mouse IgG (Fc) IgG, unlabeled

40151-UL 1 mg
EUR 255.6

Rabbit OVA IgG(Ovalbumin IgG) ELISA Kit

ERB0151 96T
EUR 681.12
Description: Method of detection: Indirect ELISA;Reacts with: Rabbit;Sensitivity: 1.875 ng/ml

Human Leptospira IgG(Lep IgG)ELISA Kit

GA-E1814HM-48T 48T
EUR 346.8

Human Leptospira IgG(Lep IgG)ELISA Kit

GA-E1814HM-96T 96T
EUR 559.2

Mouse Leptospira IgG(Lep IgG)ELISA Kit  

GA-E0170MS-48T 48T
EUR 403.2

Mouse Leptospira IgG(Lep IgG)ELISA Kit  

GA-E0170MS-96T 96T
EUR 640.8

Human Leptospira IgG(Lep IgG)ELISA Kit

QY-E03346 96T
EUR 433.2

Mouse Leptospira IgG(Lep IgG)ELISA Kit

QY-E20903 96T
EUR 433.2

Mouse Leptospira IgG,Lep IgG ELISA Kit  

YLA0687MO-48T 48T
EUR 465

Mouse Leptospira IgG,Lep IgG ELISA Kit  

YLA0687MO-96T 96T
EUR 600

Human Leptospira IgG,Lep IgG ELISA Kit

YLA2781HU-48T 48T
EUR 435

Human Leptospira IgG,Lep IgG ELISA Kit

YLA2781HU-96T 96T
EUR 562.5

Human measlesvirus IgG,MV IgG ELISA Kit

201-12-1773 96 tests
EUR 528
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Human measlesvirus IgG(MV IgG)ELISA Kit

GA-E1789HM-48T 48T
EUR 346.8

Human measlesvirus IgG(MV IgG)ELISA Kit

GA-E1789HM-96T 96T
EUR 559.2

Rabbit Leptospira IgG,Lep IgG ELISA Kit

GA-E0125RB-48T 48T
EUR 391.2

Rabbit Leptospira IgG,Lep IgG ELISA Kit

GA-E0125RB-96T 96T
EUR 628.8

Canine Leptospira IgG(Lep IgG)ELISA Kit

QY-E70163 96T
EUR 511.2

Human measlesvirus IgG(MV IgG)ELISA Kit

QY-E02206 96T
EUR 433.2

Rabbit Leptospira IgG,Lep IgG ELISA Kit

QY-E30174 96T
EUR 448.8

IgG antibody

10-2705 1 mg
EUR 159.6
Description: Mouse Monoclonal IgG antibody

IgG Antibody

1-CSB-PA00770E0Gp
  • EUR 380.40
  • EUR 402.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against IgG. Recognizes IgG from Goat. This antibody is Unconjugated. Tested in the following application: ELISA, WB; Recommended dilution: WB:1:1000-1:5000

IgG Antibody

1-CSB-PA00790E0Rb
  • EUR 380.40
  • EUR 402.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against IgG. Recognizes IgG from Human. This antibody is Unconjugated. Tested in the following application: ELISA, WB; Recommended dilution: WB:1:1000-1:5000

IgG Antibody

1-CSB-PA00760E0Gp
  • EUR 380.40
  • EUR 402.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against IgG. Recognizes IgG from Goat. This antibody is Unconjugated. Tested in the following application: ELISA

IgG Antibody

1-CSB-PA00780E0Gp
  • EUR 380.40
  • EUR 402.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against IgG. Recognizes IgG from Human. This antibody is Unconjugated. Tested in the following application: ELISA

Rabbit Anti-Human IgG (Fc) IgG, unlabeled

10119-R 0.5 mg
EUR 169.2

Human Papillomavirus IgG (HPV IgG) ELISA Kit

abx052750-96tests 96 tests
EUR 801.6

Lebtospira IgG/ Rat Lebtospira IgG ELISA Kit

ELA-E1279r 96 Tests
EUR 1063.2

Human Cytomegalovirus IgG / IgM, Toxoplasma IgG / IgM, Rubella IgG Rapid Test Kit

abx092078-20tests 20 tests
EUR 410.4

Human LPS IgG(lipopolysaccharide IgG) ELISA Kit

EH4142 96T
EUR 628.92
Description: Method of detection: Indirect ELISA;Reacts with: Homo sapiens;Sensitivity: 0.938 ng/ml

Human lipopolysaccharide IgG(LPS IgG) ELISA Kit

YLA4332HU-48T 48T
EUR 435

Human lipopolysaccharide IgG(LPS IgG) ELISA Kit

YLA4332HU-96T 96T
EUR 562.5

Human Lipopolysaccharides IgG (LPS IgG) ELISA Kit

abx257276-96tests 96 tests
EUR 764.4

Rabbit Anti-Sheep IgG (Fc) IgG, aff pure

30619 1 mg
EUR 255.6

Human Mumps Virus IgG (MuV IgG) ELISA Kit

abx364851-96tests 96 tests
EUR 651.6

Human Herpes virus type 6 IgG(hhv6 IgG)

QY-E05688 96T
EUR 433.2

Human Herpes virus type 7 IgG(hhv7 IgG)

QY-E05689 96T
EUR 433.2

Human Measles Virus IgG (MV IgG) ELISA Kit

abx364849-96tests 96 tests
EUR 651.6

Human Tetanus Toxoid IgG (TT IgG) ELISA Kit

abx364850-96tests 96 tests
EUR 651.6

Goat Anti-Turkey IgG (H+L) IgG, Unlabeled

60600-UL 1 mg
EUR 315.6

Human Adenovirus (ADV) IgG (ADV IgG) ELISA Kit

abx364854-96tests 96 tests
EUR 613.2

Hp-IgG/ Rat Hp- IgG ELISA Kit

ELA-E1387r 96 Tests
EUR 1063.2

PV-IgG/ Rat PV- IgG ELISA Kit

ELA-E1659r 96 Tests
EUR 1063.2

Rabbit Anti-Mouse Agouti IgG, IgG aff pure

AGO11-A 100 ug
EUR 578.4

Rat Helicobacter Pylori IgG (Hp IgG) CLIA Kit

abx197121-96tests 96 tests
EUR 990

Goat Anti-Human IgG (Fc) IgG-HRP Conjugate

10119-HP 0.5 ml
EUR 255.6

Goat Anti-Mouse IgG (Fc) IgG-HRP Conjugate

40151-HRP 1 ml
EUR 270

Human Diphtheria Toxoid IgG (DT IgG) ELISA Kit

abx364847-96tests 96 tests
EUR 651.6

Rat Helicobacter Pylori IgG (Hp IgG) ELISA Kit

abx354581-96tests 96 tests
EUR 943.2

Human Fasciola Hepatica IgG(FH IgG)ELISA Kit

YLA4251HU-48T 48T
EUR 435

Human Fasciola Hepatica IgG(FH IgG)ELISA Kit

YLA4251HU-96T 96T
EUR 562.5

Goat Anti-Mouse IgG (Fc) IgG-FITC Conjugate

40151-FITC 1 ml
EUR 270

Human Treponema pallidum IgG (TP IgG) ELISA Kit

QY-E05282 96T
EUR 433.2

Hamster Mono Anti-Mouse CD3e IgG (Hamster IgG)

MCD003E-M 100 Tests
EUR 578.4

Hamster Mono Anti-Mouse CD3z IgG (Hamster IgG)

MCD003Z-M 100 ug
EUR 578.4

Goat Anti-Mouse IgG (Fc) IgG-Biotin Conjugate

40151-BT 1 ml
EUR 270

Human Adenovirus Antibody IgG (ADV IgG) ELISA Kit

abx052155-96tests 96 tests
EUR 801.6

GOAT Japanese Encephalitis IgG(JE IgG) ELISA Kit

YLA0021GO-48T 48T
EUR 465

GOAT Japanese Encephalitis IgG(JE IgG) ELISA Kit

YLA0021GO-96T 96T
EUR 600

Human Japanese Encephalitis IgG,JE IgG ELISA Kit

201-12-1586 96 tests
EUR 528
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Human Chlamydia pneumoniae IgG,Cpn IgG ELISA Kit

201-12-2076 96 tests
EUR 528
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Human Japanese Encephalitis IgG (JE IgG) ELISA Kit

abx053477-96tests 96 tests
EUR 801.6

Human Parainfluenza Virus IgG (HPIV IgG) ELISA Kit

abx364871-96tests 96 tests
EUR 651.6

Human Chlamydia Pneumoniae IgG (CPn IgG) ELISA Kit

abx364873-96tests 96 tests
EUR 651.6

Human Japanese Encephalitis IgG(JE IgG)ELISA Kit

GA-E1602HM-48T 48T
EUR 346.8

Human Japanese Encephalitis IgG(JE IgG)ELISA Kit

GA-E1602HM-96T 96T
EUR 559.2

Human Japanese Encephalitis IgG(JE IgG)ELISA Kit

QY-E02250 96T
EUR 480

Human Chlamydia pneumoniae IgG(Cpn IgG)ELISA Kit

QY-E03601 96T
EUR 433.2

Sheep Japanese Encephalitis IgG(JEV IgG) ELISA Kit

YLA0071SH-48T 48T
EUR 540

Sheep Japanese Encephalitis IgG(JEV IgG) ELISA Kit

YLA0071SH-96T 96T
EUR 645

Mouse Monoclonal Anti-Human IgG (Fc) IgG, unlabeled

10118-UL 0.25 mg
EUR 270

Chicken Japanese Encephalitis IgG (JE IgG) ELISA Kit

abx053476-96tests 96 tests
EUR 801.6

Chicken Japanese Encephalitis IgG,JE IgG ELISA Kit

CN-00826C1 96T
EUR 565.2

Chicken Japanese Encephalitis IgG,JE IgG ELISA Kit

CN-00826C2 48T
EUR 386.4

Pig Anticardiolipin Antibody IgG (aCL IgG) ELISA Kit

abx361882-96tests 96 tests
EUR 990

Chicken Japanese Encephalitis IgG,JE IgG ELISA Kit

QY-E80072 96T
EUR 511.2

Donkey IgG (non-immune, isotype control) IgG, purified

20015-10 10 mg
EUR 343.2

Human Anticardiolipin Antibody IgG (aCL IgG) ELISA Kit

abx253447-96tests 96 tests
EUR 764.4

Mouse Anticardiolipin Antibody IgG (aCL IgG) ELISA Kit

abx254641-96tests 96 tests
EUR 764.4

Sheep Anticardiolipin Antibody IgG (aCL IgG) ELISA Kit

abx364584-96tests 96 tests
EUR 1111.2

Human Anticardiolipin Antibody IgG (aCL IgG) ELISA Kit

abx354313-96tests 96 tests
EUR 943.2

Mouse Anticardiolipin Antibody IgG (aCL IgG) ELISA Kit

abx354531-96tests 96 tests
EUR 943.2

Monkey Anticardiolipin Antibody IgG (aCL IgG) ELISA Kit

abx359940-96tests 96 tests
EUR 990

Rabbit Anticardiolipin Antibody IgG (aCL IgG) ELISA Kit

abx362353-96tests 96 tests
EUR 990

Dog IgG (Fc)

31C-CH0404 1 mg
EUR 552
Description: Purified Dog IgG (Fc)

Rat IgG (Fc)

31C-CH1204 1 mg
EUR 440.4
Description: Purified Rat IgG (Fc)

Pig IgG (Fc)

31C-CH1404 1 mg
EUR 536.4
Description: Purified Pig IgG (Fc)

Rat IgG Fc

31R-1080 1 mg
EUR 457.2
Description: Purified native IgG Fc protein (Rat)

Chicken Anticardiolipin Antibody IgG (aCL IgG) ELISA Kit

abx355873-96tests 96 tests
EUR 990

Cat IgG (HRP)

65C-CH0203 1 mg
EUR 297.6
Description: Purified Cat IgG HRP conjugate

Dog IgG (HRP)

65C-CH0403 1 mg
EUR 301.2
Description: Purified Dog IgG HRP conjugate

Rat IgG (HRP)

65C-CH1203 1 mg
EUR 309.6
Description: Purified Rat IgG HRP conjugate

Pig IgG (HRP)

65C-CH1403 1 mg
EUR 240
Description: Purified Pig IgG HRP conjugate

Dog IgG (Fab)

31C-CH0410 1 mg
EUR 428.4
Description: Purified Dog IgG (Fab)

Goat IgG (Fc)

31C-CH0504 2 mg
EUR 519.6
Description: Purified Goat IgG (Fc)

Rat IgG (Fab)

31C-CH1210 2 mg
EUR 408
Description: Purified Rat IgG (Fab)

Goat IgG Fc

31R-1076 1 mg
EUR 457.2
Description: Purified native IgG Fc protein (Goat)

Rat IgG Fab

31R-1079 1 mg
EUR 548.4
Description: Purified native IgG Fab protein (Rat)

HDV-IgG hepatitis D IgG ELISA test

88 96T/Box Ask for price
Description: ELISA based test for quantitative detection of HDV-IgG hepatitis D IgG

Rabbit Anti-Mouse IgG (H+L) IgG, aff pure

40319-R 1 mg
EUR 242.4

Cat IgG (FITC)

65C-CH0202 1 mg
EUR 272.4
Description: Purified Cat IgG FITC conjugate

Dog IgG (FITC)

65C-CH0402 1 mg
EUR 272.4
Description: Purified Dog IgG FITC conjugate

Goat IgG (HRP)

65C-CH0503 1 mg
EUR 271.2
Description: Purified Goat IgG HRP conjugate

Rat IgG (FITC)

65C-CH1202 1 mg
EUR 240
Description: Purified Rat IgG FITC conjugate

Pig IgG (FITC)

65C-CH1402 1 mg
EUR 212.4
Description: Purified Pig IgG FITC conjugate

Human IgG Fc

65R-1006 1 mg
EUR 536.4
Description: Human IgG Fc Fragment (FITC)

Goat Rat IgG

A23640-01ml 0.1ml
EUR 111.6
Description: A polyclonal antibody for detection of Goat Rat IgG from Rat. This Goat Rat IgG antibody is for IF, ICC, FCM. It is Affinity purified using solid phase Rat IgG (H&L) with finally > 95% purity based on SDS-PAGE and conjugated to Dylight 649. The antibody is produced in goat by using as an immunogen Rat IgG whole molecule

Goat Rat IgG

A23640-05ml 0.5ml
EUR 268.8
Description: A polyclonal antibody for detection of Goat Rat IgG from Rat. This Goat Rat IgG antibody is for IF, ICC, FCM. It is Affinity purified using solid phase Rat IgG (H&L) with finally > 95% purity based on SDS-PAGE and conjugated to Dylight 649. The antibody is produced in goat by using as an immunogen Rat IgG whole molecule

Goat Rat IgG

A21040-01ml 0.1ml
EUR 92.4
Description: A polyclonal antibody for detection of Goat Rat IgG from Rat. This Goat Rat IgG antibody is for WB, IHC-P, ELISA. It is Affinity purified using solid phase Rat IgG (H&L) with finally > 95% purity based on SDS-PAGE and conjugated to HRP. The antibody is produced in goat by using as an immunogen Rat IgG whole molecule

Goat Rat IgG

A21040-05ml 0.5ml
EUR 189.6
Description: A polyclonal antibody for detection of Goat Rat IgG from Rat. This Goat Rat IgG antibody is for WB, IHC-P, ELISA. It is Affinity purified using solid phase Rat IgG (H&L) with finally > 95% purity based on SDS-PAGE and conjugated to HRP. The antibody is produced in goat by using as an immunogen Rat IgG whole molecule

Goat Rat IgG

A23240-01ml 0.1ml
EUR 111.6
Description: A polyclonal antibody for detection of Goat Rat IgG from Rat. This Goat Rat IgG antibody is for IF, ICC, FCM. It is Affinity purified using solid phase Rat IgG (H&L) with finally > 95% purity based on SDS-PAGE and conjugated to Dylight 488. The antibody is produced in goat by using as an immunogen Rat IgG whole molecule

Goat Rat IgG

A23240-05ml 0.5ml
EUR 268.8
Description: A polyclonal antibody for detection of Goat Rat IgG from Rat. This Goat Rat IgG antibody is for IF, ICC, FCM. It is Affinity purified using solid phase Rat IgG (H&L) with finally > 95% purity based on SDS-PAGE and conjugated to Dylight 488. The antibody is produced in goat by using as an immunogen Rat IgG whole molecule

Goat Rat IgG

A23340-01ml 0.1ml
EUR 111.6
Description: A polyclonal antibody for detection of Goat Rat IgG from Rat. This Goat Rat IgG antibody is for IF, ICC, FCM. It is Affinity purified using solid phase Rat IgG (H&L) with finally > 95% purity based on SDS-PAGE and conjugated to Dylight 549. The antibody is produced in goat by using as an immunogen Rat IgG whole molecule

Goat Rat IgG

A23340-05ml 0.5ml
EUR 268.8
Description: A polyclonal antibody for detection of Goat Rat IgG from Rat. This Goat Rat IgG antibody is for IF, ICC, FCM. It is Affinity purified using solid phase Rat IgG (H&L) with finally > 95% purity based on SDS-PAGE and conjugated to Dylight 549. The antibody is produced in goat by using as an immunogen Rat IgG whole molecule

Goat Rat IgG

A23440-01ml 0.1ml
EUR 111.6
Description: A polyclonal antibody for detection of Goat Rat IgG from Rat. This Goat Rat IgG antibody is for IF, ICC, FCM. It is Affinity purified using solid phase Rat IgG (H&L) with finally > 95% purity based on SDS-PAGE and conjugated to Dylight 594. The antibody is produced in goat by using as an immunogen Rat IgG whole molecule

Goat Rat IgG

A23440-05ml 0.5ml
EUR 268.8
Description: A polyclonal antibody for detection of Goat Rat IgG from Rat. This Goat Rat IgG antibody is for IF, ICC, FCM. It is Affinity purified using solid phase Rat IgG (H&L) with finally > 95% purity based on SDS-PAGE and conjugated to Dylight 594. The antibody is produced in goat by using as an immunogen Rat IgG whole molecule

Horse IgG (Fc)

31C-CH0804 1 mg
EUR 376.8
Description: Purified Horse IgG (Fc)

Sheep IgG (Fc)

31C-CH1304 1 mg
EUR 343.2
Description: Purified Sheep IgG (Fc)

Human IgG Fc

31R-1037 1 mg
EUR 505.2
Description: Purified Human IgG Fc for use as a control or blocking reagent

Human IgG Fc

31R-1074 1 mg
EUR 457.2
Description: Purified native IgG Fc protein

Goat IgG Fab

31R-1075 1 mg
EUR 548.4
Description: Purified native IgG Fab protein (Goat)

Mouse IgG Fc

31R-1077 1 mg
EUR 457.2
Description: Purified native IgG Fc protein (Mouse)

Mouse IgG (Fc)

31-AM15FC 1 mg
EUR 543.6
Description: Purified Mouse IgG (Fc)

Human IgG(>95%)

E61I00801 100mg
EUR 1180.8

Human IgG(>95%)

E61I00802 1g
EUR 4545.6

Chicken Anti-Human+Mouse IgG+A+M IgG/Y

HGAM11-A 100 ul
EUR 578.4

Human Hantavirus IgG (HV-IgG) ELISA Kit

abx055454-96tests 96 tests
EUR 801.6

Mouse Hantavirus IgG (HV-IgG) ELISA Kit

abx055496-96tests 96 tests
EUR 801.6

ELISA kit for Mouse Sendai Virus IgG (SeV IgG)

KTE71587-48T 48T
EUR 424.8
Description: Quantitative sandwich ELISA for measuring Mouse Sendai Virus IgG (SeV IgG) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Mouse Sendai Virus IgG (SeV IgG)

KTE71587-5platesof96wells 5 plates of 96 wells
EUR 2702.4
Description: Quantitative sandwich ELISA for measuring Mouse Sendai Virus IgG (SeV IgG) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Mouse Sendai Virus IgG (SeV IgG)

KTE71587-96T 96T
EUR 686.4
Description: Quantitative sandwich ELISA for measuring Mouse Sendai Virus IgG (SeV IgG) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

Goat IgG (FITC)

65C-CH0502 1 mg
EUR 199.2
Description: Purified Goat IgG FITC conjugate

Horse IgG (HRP)

65C-CH0803 1 mg
EUR 272.4
Description: Purified Horse IgG HRP conjugate

Mouse IgG (HRP)

65C-CH1003 1 mg
EUR 309.6
Description: Purified Mouse IgG HRP conjugate

Sheep IgG (HRP)

65C-CH1303 1 mg
EUR 271.2
Description: Purified Sheep IgG HRP conjugate

Bovine IgG (Fc)

31C-CH0104 1 mg
EUR 306
Description: Purified Bovine IgG (Fc)

Horse IgG (Fab)

31C-CH0810 2 mg
EUR 408
Description: Purified Horse IgG (Fab)

Mouse IgG (Fab)

31C-CH1022 2 mg
EUR 408
Description: Purified Mouse IgG (Fab)

Rabbit IgG (Fc)

31C-CH1104 1 mg
EUR 483.6
Description: Purified Rabbit IgG (Fc)

Sheep IgG (Fab)

31C-CH1310 2 mg
EUR 408
Description: Purified Sheep IgG (Fab)

Rabbit IgG Fc

31R-1072 1 mg
EUR 457.2
Description: Purified native IgG Fc protein (Rabbit)

Human IgG Fab

31R-1073 1 mg
EUR 548.4
Description: Purified native IgG Fab protein
This assessment supplies a complete overview of each the overall perform of therapeutic antibodies and some major variations in growth, together with current introduction with the proposed mechanism of actions, and we introduce sorts of therapeutic antibodies, medical trials, and accredited business immunotherapeutic medication.

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